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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 115-117 
    Details
    ISSN: 1432-1041
    Keywords: benzodiazepine antagonist ; Ro 15-1788 ; healthy volunteers ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 has been studied in 6 healthy male volunteers following a single intravenous dose of 2.5 mg. The drug was only slightly bound to plasma proteins (40±8%, mean±SD). A negligible amount (〈0.2% of the dose) of unchanged drug was recovered in urine. Hepatic elimination was rapid, as shown by a short t1/2 of 0.9±0.2 h, and high total plasma and blood clearances of 691±216 ml/min and 716±199 ml/min, respectively. The fast decline of plasma levels from about 60 to 2 ng/ml accounts for the short-lasting reversal of benzodiazepine-induced sedation by Ro 15-1788.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02395217
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 115-117 
    Details
    ISSN: 1432-1041
    Keywords: benzodiazepine antagonist ; Ro 15-1788 ; healthy volunteers ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 has been studied in 6 healthy male volunteers following a single intravenous dose of 2.5 mg. The drug was only slightly bound to plasma proteins (40±8%, mean±SD). A negligible amount (〈0.2% of the dose) of unchanged drug was recovered in urine. Hepatic elimination was rapid, as shown by a short t1/2 of 0.9±0.2 h, and high total plasma and blood clearances of 691±216 ml/min and 716±199 ml/min, respectively. The fast decline of plasma levels from about 60 to 2 ng/ml accounts for the short-lasting reversal of benzodiazepine-induced sedation by Ro 15-1788.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553165
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  • 3
    Electronic Resource
    Electronic Resource
    Flow patterns at the site of extracranial to intracranial end to side anastomosis (1984)
    Springer
    Acta neurochirurgica 73 (1984), S. 45-57 
    Details
    ISSN: 0942-0940
    Keywords: End to side anastomosis ; flow patterns ; rheological study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Flow property measurements were performed in a plexiglass model of six various types of end-to-side anastomosis (as clinically shown in extracranial to intracranial arterial bypass surgery). Three anastomoses were made without, another three anastomoses with a ringshaped stenosis restricting the lumen to between 25 and 46% of the cross-section as it occurs clinically by formation of thrombi out of the stitching canals. A rectangular type and two 45 degree oblique types—one directed centrally and one directed peripherally—were tested. Pressure head losses at the site of anastomosis were measured under various circumstances of different anastomoses and different flow speeds along the proximal portion of the middle cerebral artery and the superficial temporal artery. Flow resistance values originated by the different types of anastomoses were expressed in terms of additional recipient vessel length. Differences between different types of anastomoses with and without stenosis were very small and under no circumstances exceeded the equivalent of lengthening the recipient vessel by 2 cm. Theoretically, the optimal type of anastomosis is the oblique and centrally directed version; the worst type is the rectangular form. Practically, however, such differences are not relevant. The explanation for such unexpectedly small differences can rheologically be given by considering the dominating role of blood viscosity under the given circumstances, other variables such as short stenosis and angling of flow playing a secondary role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401783
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  • 4
    Electronic Resource
    Electronic Resource
    A Direct Hexane Extraction Process for Glanded Cottonseed (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 47 (1982), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A modified filter funnel apparatus was used to determine mass flow velocities for extraction of uncooked glanded cottonseed flakes, and the results were compared with a continuous pilot-plant-scale extractor. A mass velocity of 2,000 lb/hr/ft2 or higher (considered adequate for oilseed extraction) was obtained in all cases. Both the initial meat moisture before flaking and the flake moisture during extraction were found to affect the mass velocity. A meat moisture before flaking of less than 9% decreased the mass velocity, probably as a result of increased fines and thus smaller flake size. A high flake moisture (about 9%) during heated-hexane extraction caused a decrease in mass velocity compared to that of lower-moisture flakes. The correlation of filter-funnel mass velocity data to a continuous pilot-plant extractor confirmed that uncooked flakes can be satisfactorily extracted to yield low residual lipids by using a low solvent-to-flake ratio and ambient-temperature hexane solvent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1982.tb11087.x
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  • 5
    Electronic Resource
    Electronic Resource
    PROTEIN DISPLACEMENT DURING CLASSIFICATION OF GLANDED COTTONSEED (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 45 (1980), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The effects of classification of glanded cottonseed flour on protein displacement were studied. Media were liquid (nonpolar solvent) and air. The fines and coarse fractions had different ratios of water-soluble functional and storage proteins than the starting material. The difference in protein distribution was reflected in the contents of essential amino acids of each fraction. Fines or “overs” fractions had lower amounts of some limiting essential amino acids such as lysine, threonine and leucine as compared with the coarse fraction. Degossypolised cottonseed flour therefore had lower protein quality than the starting material. Although the fines fractions have lower amounts of essential amino acids as compared with the coarse fractions, they did not differ in the type of proteins as shown by gel electrophoresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1980.tb07564.x
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  • 6
    Electronic Resource
    Electronic Resource
    HEAT-INDUCED TRANSITIONS IN THE PROTEIN-PROTEIN INTERACTION OF BOVINE NATURAL ACTOMYOSIN (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food biochemistry 8 (1984), S. 0 
    Details
    ISSN: 1745-4514
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Protein-protein interaction of bovine natural actomyosin (NAM) was studied by means of optical density changes resulting from discrete particle formation in the temperature range of4°C to 70°C. From Arrhenius plots, the apparent heat of activation (ΔHa) at pH 5.5 (17.1 kcallmole) was significantly (P〈0.05) lower than activation energies in the pH range of 6.0 to 7.5. The lower Δ Ha resulted in initiation of protein-protein interaction at a temperature near 16°C at pH 5.5, whereas interaction did not proceed until the temperature approached 37°C at pH 6.0 and above. Derivative curves (dOD/dT) at pH 5.5 and 6.0 showed two distinct NAM thermal transition regions. Tm1 occurred at 43.0°C at pH 5.5 and 48.5°C at pH 6.0, with the 5.5°C difference possibly arising from effects of proton binding in altering protein conformation. Only a 1.5°C difference in Tm2 (56.0°C at pH 5.5 versus 57.5°C at pH 6.0) was found. Although the overall heat-mediated NAM aggregation (in dilute solution) was found to follow first order kinetics by two evaluation methods, the existence of two thermal transitions supports a two-step reaction mechanism proposed for the formation of protein gels (in higher concentration solutions).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-4514.1984.tb00311.x
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of Liquid Smoke on the Growth of Lactic Acid Starter Cultures used to Manufacture Fermented Sausage (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 47 (1982), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Fermented sausage was manufactured using a commercial lactic acid starter culture and varying levels of liquid smoke. Samples were taken during the 24 hr fermentation period and the lactic bacterial count, pH and titratable acidity determined. Final pH values, titratable acidity and lactic bacterial counts were not affected by recommended use levels of liquid smoke, although exponential growth was delayed. Growth studies in a broth medium containing liquid smoke suggest that liquid smoke has the potential for inhibiting the lactic starter cultures used to make fermented sausage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1982.tb12953.x
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  • 8
    Electronic Resource
    Electronic Resource
    Medizinische Prophylaxe bei Bleiexposition (1981)
    Springer
    Sozial- und Präventivmedizin 26 (1981), S. 146-147 
    Details
    ISSN: 1420-911X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'action du plomb sur le métabolisme intermédiaire, spécialement sur la synthèse de l'hème, est bien connue. Par voie de conséquence, la surveillance biologique des personnes exposées au plomb qui recourt au dosage urinaire des métabolites urinaires de la porphyrine est tout à fait fondée. La surveillance biologique par le dosage du métabolite urinaire de l'acide delta-amino-lévulinique est pratiquée depuis plus de dix ans sur une vaste échelle par la Caisse nationale suisse d'assurance en cas d'accidents. Aujourd'hui, plus de 3000 travailleurs dans une centaine d'usines sont périodiquement surveillés de cette manière. Les analyses urinaires sont pratiquées à des intervalles réguliers de 2, 4 ou 6 mois selon le degré de l'exposition au plomb; on y ajoute un examen médical une à deux fois par année. Grâce à la surveillance biologique, aux améliorations techniques et à l'hygiène personnelle, on n'a pas observé de cas d'intoxications au plomb ces dernières années.
    Abstract: Summary The action of lead on the intermediary metabolism, especially on the synthesis of heme, the red blood cell pigment, is well documented. Therefore biological monitoring of lead exposed persons by means of the urinary metabolites of porphyrin metabolism is very valuable. Biological monitoring through the urinary metabolite — aminolevulinic acid (ALAU) has been put to extensive use for over ten years by the Swiss National Accident Insurance Fund (Suva). At present there are over 3000 workers in 100 factories which are periodically screened for this metabolite. Urinary analyses are carried out at regular intervals of 2, 4 or 6 months according to the lead exposition with additional medical examinations once or twice a year. Due to biological monitoring, technical improvements and personal hygiene there have been no further lead poisoning recently in industrial plants supervised by Suva.
    Notes: Zusammenfassung Aufgrund der gut untersuchten Wirkung des Bleis auf den Intermediärstoffwechsel, insbesondere auf die Bildung des roten Blutfarbstoffes, eignen sich die anfallenden Metaboliten des Porphyrinstoffwechsels in besonderer Weise für die biologische Überwachung von bleiexponierten Personen. Dies wurde in den letzten zehn Jahren von der Suva genutzt und hat dazu beigetragen, das Problem der Bleivergiftung in den überwachten Industriebetrieben weitgehend zu eliminieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02081373
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  • 9
    Electronic Resource
    Electronic Resource
    Mikroanalyse an Verbundwerkstoffen (1981)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 12 (1981), S. 107-108 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19810120312
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  • 10
    Electronic Resource
    Electronic Resource
    Keramik als Konstruktionswerkstoff (1982)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 13 (1982), S. 221-227 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19820130607
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