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  • 1
    Electronic Resource
    Electronic Resource
    Determination of phenylbutazone, tolbutamide and metabolites in plasma and urine using chemical ionization mass spectrometry (1977)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 4 (1977), S. 42-47 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Quantitative analytical procedures for the analysis of phenylbutazone and tolbutamide levels in plasma have been developed which involve the addition of deuterium labeled internal standards to plasma followed by extraction and direct sample insertion into a mass spectrometer operating under chemical ionization conditions. Peak height ratios used to calculate plasma levels were determined by using either selected ion monitoring or repetitive scan data. The scan approach was used in a related procedure for the simultaneous determination of tolbutamide and two metabolites from urine. The accuracy, precision and sensitivity of the direct sample insertion approach to drug level measurement has been determined. Examples are given of data obtained in the course of pharmacokinetic studies in which this analytical approach appears to offer advantages in the analysis of multicomponent mixtures encountered in drug-drug interaction studies.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200040105
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  • 2
    Electronic Resource
    Electronic Resource
    Properties of β-amylase immobilized to alkylamine porous silica (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 21 (1979), S. 505-512 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260210312
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immobilization and characterization of hog kidney mutarotase (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 19 (1977), S. 923-928 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260190610
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  • 4
    Electronic Resource
    Electronic Resource
    Experimental operation of immobilized multienzyme systems in optimal and suboptimal configurations (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 20 (1978), S. 243-253 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Two mixed immobilized enzyme systems, glucoamylase-glucose isomerase and glucose isomerase-glucose oxidase-catalase, were operated to verify theoretical predictions that optimal bifunctional catalyst configutations could exist superior to those where the catalysts were mixed uniformly or arranged sequentially in a tubular reactor. The experimental results for all three configurations conformed to the theoretical values sufficiently closely to support of optimal catalyst profiles.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260200207
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  • 5
    Electronic Resource
    Electronic Resource
    Pilot plant production of glucose with glucoamylase immobilized to porous silica (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 18 (1976), S. 253-267 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Glucoamylase was immobilized to porous silica and its kinetics and stability were observed with acid- and α-amylase-hydrolyzed dextrin as feed. The enzyme was found to be extremely stable in both laboratory and pilot plant operations. When the feed had been previously only lightly hydrolyzed, pore diffusion limitation caused appreciable decreases in glucose production rate. The severity of starch hydrolysis to dextrin markedly affected ultimate glucose yields. The diffusional gradients present in the carrier pores caused the immobilized enzyme to yield lower glucose concentrations than the free enzyme at similar feed conditions.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260180210
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  • 6
    Electronic Resource
    Electronic Resource
    Cellular and subcellular localization of 3H-diethylstilboestrol in the central nervous system (1977)
    Springer
    Cell & tissue research 183 (1977), S. 379-384 
    Details
    ISSN: 1432-0878
    Keywords: Brain ; Rat ; Diethylstilboestrol ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The cellular and subcellular localization of radioactivity in the brain of immature female rats was determined by dry-mount autoradiography 2 h after iv injection of 1.0 μg of (monethyl-3H) diethylstilboestrol per 100 g body weight. A specific topographic pattern of nuclear concentration of the synthetic oestrogen was obtained similar to that for 3H-oestradiol-17β in specific neurons of the basal hypothalamus, preoptic region and amygdala. In competition experiments, the nuclear concentration of radioactivity in all areas studied was inhibited by unlabeled oestradiol, while unlabeled testosterone had no effect. These data suggest that although oestradiol can bind to androgen receptors, the oestrogen receptor itself can account for the localization seen after the injection of 3H-oestradiol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220644
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  • 7
    Electronic Resource
    Electronic Resource
    The conformational transition in poly(methacrylic acid) and butyl vinyl ether/maleic anhydride copolymers studied by 1H NMR linewidth measurements (1976)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 177 (1976), S. 885-893 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Messungen der Linienbreite in den 1H NMR-Spektren von D2O Lösungen von Polymethacrylsäure (PMA) und von hydrolysiertem Butylvinyläther/Maleinsäureanhydrid Copolymer zeigen eine scharfe Abnahme der Linienbreite der Seitenkettenresonanzsignale bei einem Neutralisationsgrad α ≈ 0,2. Dies ist der Bereich, in dem schon früher potentiometrische Titrationen einen Konformationsübergang aufzeigten. Ein solcher Wechsel tritt weder bei der Polyacrylsäure noch beim Methylvinyläther/Maleinsäureanhydrid Copolymer auf. Die Art des Konformationsübergangs wird auf der Grundlage der Rotationsfreiheit der Seitenketten um die Hauptkette diskutiert.
    Notes: Linewidth measurements on the 1H NMR spectra of D2O solutions of poly(methacrylic acid), (PMA), and the hydrolyzed form of butyl vinyl ether/maleic anhydride copolymer show a sharp decrease in the linewidths of side chain resonances at a degree of neutralization α ≈ 0,2. This is the region in which potentiometric titrations previously have shown a conformational transition to occur. Such a change does not occur in poly(acrylic acid) on the one hand and methyl vinyl ether/maleic anhydride copolymer on the other. The nature of the transition is discussed in terms of the freedom of rotation of the side chains about the main chain.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1976.021770325
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  • 8
    Electronic Resource
    Electronic Resource
    Potassium hydroxide inhibition in poly(propylene oxide) autoxidation (1977)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 178 (1977), S. 465-474 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A systematic study of the effect of potassium hydroxide on the autoxidation of poly(propylene oxide)s with number average molecular weights, M̄n, in the range 400-3000 has been made in the range of temperature 110-140°C. For all the polymers a considerable increase in the induction time was produced by KOH in solution in the polymer, the increase being most marked for the polymer of lowest molecular weight. For the polymers of molecular weight 1000 and lower, the rate of the subsequent autoxidation was considerably reduced by the KOH, the effect being greatest for the polymer of molecular weight 400. For polymers of molecular weight 2000 and above no change in rate was observed. The effectiveness of KOH as an antioxidant is shown to depend on the concentration of terminal hydroxyl groups and is explained by the non-radical decomposition of RO-2 ions.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1977.021780218
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  • 9
    Electronic Resource
    Electronic Resource
    A model for the simulation of an aqueous dipeptide solution (1979)
    New York : Wiley-Blackwell
    Biopolymers 18 (1979), S. 825-854 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A model for the simulation of a solution of an alanine dipeptide in water is presented that combines a previous model for bulk water (ST2) with that used in conformational energy studies on small molecules and proteins. The results of a pilot molecular dynamics study indicate that the model leads to reasonable solvent-solute interactions. No evidence is found for substantial changes in the structure or dynamics of the dipeptide in solution as compared to in vacuo. Furthermore, at the elevated temperature examined, there appear to be no significant effects on the dynamics or intermolecular bonding of the water molecules in contact with the solute.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1979.360180407
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  • 10
    Electronic Resource
    Electronic Resource
    Characterization of the A ⇄ B transition of DNA in fibers and gels by laser Raman spectroscopy (1975)
    New York : Wiley-Blackwell
    Biopolymers 14 (1975), S. 1245-1257 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Both Raman spectra and X-ray diffraction patterns have been obtained from oriented fibers of sodium deoxyribonucleic acid (Na-DNA) as a function of salt content and relative humidity. We have confirmed the previously reported X-ray results that, for oriented fibers, the A-form always exists between 75 and 92% relative humidity and that the conformation will change to the B-form at 92% relative humidity only if an excess (3-5%) of added salt is present. Oriented fibers containing low amounts of added salt remain in the A-type conformation at 92% relative humidity and higher. An exact correlation has been found between the familiar A- and B-type X-ray diffraction patterns of DNA fibers and the Raman spectra previously reported without X-ray verification from this laboratory for the A- and B-forms. In particular, a band at 807 cm-1 was always present when a fiber showed the A-type diffraction pattern, and this band shifts to 790 cm-1 in the B-form. Using the Raman spectrum to determine the specific conformation of DNA in samples less amenable to X-ray analysis, we have studied the A ⇄ Btransformation in unoriented fibrous masses of DNA and in concentrated, oriented gels. We find that in unoriented fibrous masses, the A ⇄ B transition always occurs at 92% relative humidity even at very low salt concentration (0-4%). However, in oriented DNA gels at low salt, the A-form can persist as a metastable state to concentration as low as 20% DNA. The origin of the bands at 807 and 790 cm-1 and the possible biological implications of these findings are discussed.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1975.360140613
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