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Morphine and β-endorphin inhibit release of noradrenaline from cerebral cortex but not of dopamine from rat striatum (1978)

ARBILLA, S. ; LANGER, S. Z.

[s.l.] : Nature Publishing Group

Nature 271 (1978), S. 559-561

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Male rats of 150 to 200 g were killed by decapitation. Slices of 0.3 mm thickness were obtained from the rat corpus striatum and occipital cerebral cortex with a Mcllwain tissue chopper. The slices were transferred to the incubation medium in an open lucite cylinder with a nylon mesh fitted to the ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/271559a0

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Facilitation by GABA of the potassium-evoked release of 3H-noradrenaline from the rat occipital cortex (1979)

Arbilla, S. ; Langer, S. Z.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 306 (1979), S. 161-168

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ISSN: 1432-1912

Keywords: Noradrenaline ; GABA ; Tyramine ; Rat occipital cortex ; Cat nictitating membrane

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The effects of GABA were studied on the release of 3H-noradrenaline (3H-NA) evoked by potassium or by tyramine from slices of the rat occipital cortex and on the release of 3H-NA elicited by nerve stimulation from the cat nictitating membrane. GABA (30–1000μM) facilitated the potassium-evoked release of 3H-NA in a concentration dependent manner. This facilitatory effect was not antagonized by bicuculline (1–100 μM) or by picrotoxin (1–100 μM). Exposure to the GABA agonist muscimol (1–100 μM) did not affect either the spontaneous or the potassium-evoked release of 3H-NA. The facilitatory effect of GABA on the release of 3H-NA elicited by potassium was observed when the occipital cortex slices were exposed to 20 mM K+ during 1 min. When depolarization was induced by 35 mM K+ exposure to GABA failed to enhance the release of the neurotransmitter. GABA 300 μM did not affect the release of the labelled neurotransmitter evoked by exposure to tyramine 0.6 μM. In the cat nictitating membrane prelabelled with 3H-NA, the stimulation evoked release of the labelled neurotransmitter was not affected by GABA (10–300 μM). In conclusion, GABA has a facilitatory effect on the calcium-dependent, potassium evoked release of 3H-NA when the depolarization is of moderate degree. This effect of GABA appears to be selective for the central nervous system.