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  • 1
    Electronic Resource
    Electronic Resource
    Pancreatic endocrine response to the first feed in term newborn infants (1979)
    Springer
    European journal of pediatrics 132 (1979), S. 189-195 
    Details
    ISSN: 1432-1076
    Keywords: First feed ; Newborn ; Insulin ; Glucagon ; C-peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Blood glucose, insulin, C-peptide and glucagon were evaluated in 36 newborn term infants at birth, and before and 60 min after the first feed during the first day of life. Under basal conditions glycaemia diminished during the first day of life and glucagon increased, while insulin and C-peptide did not show any variation. The C-peptide: insulin molar ratio was higher in the newborn than in adults because of the longer half-life of C-peptide, probably due to reduced renal function in the neonatal period. The subjects were divided into two groups: 18 newborn infants were given a feed of commercially available milk powder reconstituted in water at 10% (5 ml/kg); the other 18 were given a feed of 5 ml/kg 10% glucose solution. In each group 6 were given the first feed after a fast of 6 h, 6 after a fast of 12 h, and 6 after a fast of 24 h from birth. After the first feed with milk, the average increase of glycaemia was 19.83 mg%, of insulin 6.06 μU/ml, and of C-peptide 1.88 ng/ml. After the first feed with glucose the average increase of glycaemia was 13.59 mg%, of insulin 2.46 μU/ml, and of C-peptide 0.59 ng/ml. Glucagon did not show significant changes after the first feed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442435
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Parathyroid hormone and calcitonin levels in vitamin D deficient rickets (1979)
    Springer
    European journal of pediatrics 130 (1979), S. 137-145 
    Details
    ISSN: 1432-1076
    Keywords: Vitamin D deficient rickets ; Parathyroid hormone ; Calcitonin ; Urinary hydroxyproline ; Urinary cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In six infants aged between 5 and 8 months with vitamin D deficient rickets, we have studied blood levels of calcium (Ca), phosphorus (P), alkaline phosphatase, immunoreactive parathyroid hormone (PTH) and calcitonin (CT), as well as urinary excretion of Ca, P, hydroxyproline and cyclic AMP, both under basal conditions and during a 4 h infusion of 20 mg/kg 10% Ca gluconate in normal saline. Under basal conditions all the infants had high alkaline phosphatase (range: 470–770 U.I/l); PTH (range: 620–1200 pg Eq/ml) and CT (range: 440–750 pg/ml) but two infants had hypocalcaemia and four had normocalcaemia and hypophosphataemia. The urinary Ca excretion was low whereas the urinary P, hydroxyproline and cyclic AMP excretions were high. During Ca infusion the total serum Ca and CT levels increased, while alkaline phosphatase and PTH fell. After the end of the infusion, CT levels fell perceptibly; phosphaturia, hydroxyprolinuria and cyclic AMP decreased on the day of the infusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442350
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis of RNA and protein in a mutant of Bacillus subtilis temperature sensitive during spore germination (1976)
    Springer
    Molecular genetics and genomics 148 (1976), S. 159-164 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Bacillus subtilis strain PB 2427 temperature sensitive in the synthesis of RNA during spore germenation and outgrowth has been characterized to some extent. At non permissive temperature (46°C) strain PB 2427 synthesizes stable and unstable RNA for 50 min from the beginning of germination and then stops. Most of the stable RNA is degraded to shorter molecules but can be identified as ribosomal RNA by hybridization-competition experiments. At non permissive temperature, in the presence of chloramphenicol, synthesis of RNA proceeds, though at a reduced rate, for at least 90 min. By hybridization-competition experiments it can also be shown that the RNA synthesized at 46° C in the presence of chloramphenicol includes transcripts that are absent, from the RNA synthesized at 46° C in the absence of drug. The RNA polymerase (holo and core) purified from vegetative cells of the mutant strain does not appear to have a greater heat-lability as compared with the enzyme purified from the parental strain. At non permissive temperature only six polypeptide chains with MW ranging from 47,000 to 78,000 daltons are synthesized by the germinating spores of the mutant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00268380
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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