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  • 1
    Electronic Resource
    Electronic Resource
    Fluorescence line narrowing spectroscopy in organic glasses containing PPB levels of polycyclic aromatic hydrocarbons (1978)
    s.l. : American Chemical Society
    Analytical chemistry 50 (1978), S. 1394-1397 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50031a052
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Response of gastric inhibitory polypeptide (GIF) to test meal in chronic pancreatitis — Relationship to endocrine and exocrine insufficiency (1976)
    Springer
    Diabetologia 12 (1976), S. 609-612 
    Details
    ISSN: 1432-0428
    Keywords: GIP ; gastrin ; insulin ; incretin ; chronic pancreatitis ; test meal ; malassimilation of fat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-nine patients with chronic pancreatitis had a significantly greater IR-GIP response to a test meal than 15 controls. This increased response was not related to the degree of steatorrhoea or glucose intolerance. It was most marked in a group of patients with moderately impaired IRI release and medium steatorrhoea. From this is concluded that the IR-GIP response to a test meal is determined by at least two factors: 1. feedback control via insulin secretion, 2. assimilation of fat. In chronic pancreatitis endocrine insufficiency may induce an exaggerated GIP response and severe exocrine insufficiency may prevent fat induced GIP release. Gastrin is not involved in the different GIP response in patients with chronic pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01220638
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  • 3
    Electronic Resource
    Electronic Resource
    Gastric inhibitory polypeptide (GIP), gastrin and insulin: Response to test meal in coeliac disease and after duodeno-pancreatectomy (1976)
    Springer
    Diabetologia 12 (1976), S. 279-286 
    Details
    ISSN: 1432-0428
    Keywords: GIP ; gastrin ; insulin ; incretin ; coeliac disease ; duodeno-pancreatectomy ; chronic pancreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response of serum immunoreactive gastric inhibitory polypeptide (IR-GIP), gastrin (IRG) and insulin (IRI) to a mixed standard meal was measured in 15 controls, 6 patients with coeliac disease, 26 patients with chronic pancreatitis and 6 patients with chronic pancreatitis and partial duodenopancreatectomy (Whipple's procedure). Serum levels of IR-GIP, IRG and IRI were significantly reduced in patients with coeliac disease. The serum glucose increase was significantly smaller only during the first hour after the meal. Since small intestinal GIP- and G-cells are situated mainly in the glands of duodenal and jejunal mucosa their absolute number is not significantly reduced in coeliac disease. It is suggested that the release of IR-GIP and duodenal IRG is influenced by the rate of absorption of nutrients. In patients with chronic pancreatitis the IR-GIP release is significantly greater than in controls, the IRG release normal and the IRI response delayed. After Whipple's procedure the IR-GIP response is increased significantly while the IRG secretion is abolished. This demonstrates that the duodenum is not necessary for GIP release and that pancreatic and jejunal gastrin are without clinical significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422096
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  • 4
    Electronic Resource
    Electronic Resource
    Gastric inhibitory polypeptide (GIP) and insulin in obesity: Increased response to stimulation and defective feedback control of serum levels (1978)
    Springer
    Diabetologia 14 (1978), S. 15-24 
    Details
    ISSN: 1432-0428
    Keywords: GIP release ; insulin release ; obesity ; pathological glucose tolerance ; feedback control of GIP secretion ; test meal ; triglyceride ingestion ; oral glucose load
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the possibility that an abnormality of the entero-insular axis is responsible for the hyperinsulinaemia of obesity, serum immunoreactive gastric inhibitory polypeptide (IR-GIP) and insulin (IRI) were measured after the ingestion of a liquid mixed test meal, glucose or fat, in normal weight and obese subjects. The latter were divided into a group with normal oral glucose tolerance (nOGT) and a group with pathological glucose tolerance (pOGT). Fasting levels of IR-GIP were significantly elevated in the obese group with pOGT. After the mixed meal the overweight subjects showed a significantly greater response of IR-GIP than the controls, with highest levels in the pOGT group. Simultaneously, the IRI response was significantly greater in the obese subjects than in the controls. The increases of IR-GIP and IRI after an oral load of 100 g glucose were normal in the obese subjects, but showed a significantly greater integrated response in the obese patients with pOGT. The ingestion of 100 g fat induced no IRI release but a significantly greater release of IR-GIP in the obese subjects, irrespective of their glucose tolerance. It is concluded that fat is a stronger releaser of IR-GIP than glucose. The effect of a combined load of glucose (30 g) and fat (100 g) was also compared in obese and normal weight subjects with the effect of either alone. Fat but not glucose released significantly more IR-GIP in obese subjects. In normal weight controls, but not in obese subjects, the IR-GIP release after fat plus glucose became significantly smaller than after fat alone. Since only the combined ingestion of glucose and fat and not fat alone releases insulin it is suggested that endogenous insulin inhibits GIP release and that this feedback control between insulin and GIP is defective in patients with obesity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429703
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  • 5
    Electronic Resource
    Electronic Resource
    Gastric inhibitory polypeptide: Effect on glucose-induced insulin release from isolated rat pancreatic islets in vitro (1975)
    Springer
    Diabetologia 11 (1975), S. 483-484 
    Details
    ISSN: 1432-0428
    Keywords: Gastric inhibitory polypeptide ; insulin release ; isolated rat islets ; enteroinsular axis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Gastric Inhibitory Polypeptide (GIF; 1 or 10 μg/ml) potentiated glucose-induced (8 or 16.6 mM) insulin (IRI) release from isolated rat pancreatic islets. Basal release was unaffected. The threshold concentration of glucose necessary for GIF to modulate IRI release was between 6 and 8 mM. GIP had no effect on IRI release from islets submitted to a maximal glucose stimulus (25 mM).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429919
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of griseofulvin on the morphology, growth and metabolism of fibroblasts in culture (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 99 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Griseofulvin was tested for its effects on the morphology, proliferation and metabolism of fibroblasts cultured from normal human skin and on established lines of mouse fibroblasts 3T3 and 3T6. In all cells treatment produced slight increases in the mitotic index compatible with transient mitotic arrest, but cultures of 3T3 and 3T6 cells also included high proportions (up to 25%) of abnormal multi-nucleate cells not present in human strains. The proliferation of all cell strains over a 2 or 4 day period was inhibited in proportion to dose (2–17 μg/ml) with 50% inhibition of growth in the range of 5-11 μg/ml. Acid mucopolysaccharide secretion was depressed by about 20% at 4–17 μg/ml. Total protein synthesis was depressed in 3T6 and in human cells, but there was no specific effect on collagen synthesis or secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb01993.x
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  • 7
    Electronic Resource
    Electronic Resource
    Why measure astrophysical X-ray spectra? (1976)
    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 340-342 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In addition to providing useful data through measurements of Doppler shifts and line profiles, a prime aim of high resolution spectrometry is the inference of source structure in terms of temperature distribution of thermal particles3?6 or energy distribution of non-thermal particles6. These ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/264340b0
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Oscillations of coronal electron traps inferred from hard X-ray data (1976)
    Springer
    Solar physics 49 (1976), S. 329-342 
    Details
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The work of Brown and Hoyng (1975) on the betatron acceleration of hard X-ray source electrons trapped in a vibrating flux tube is generalised to include Fermi acceleration by the varying transverse field. This development can explain the trajectory of bursts in a plot of equivalent thick-target electron flux $$\mathfrak{F}$$ versus spectral index γ as inferred from observations obtained by ESRO TD1A. Specifically the loops observed in this $$\mathfrak{F}$$ , λ diagram, unexplained in Brown and Hoyng's anslysis are accounted for by a changing phase relationship between the varying field strength f(t) and magnetic scale length g(t)- Application of the formalism to the detailed TD1A observations of the large events of 1972, August 4 and 7, allows inference of the evolution of f(t), g(t) in these events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00162456
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  • 9
    Electronic Resource
    Electronic Resource
    Identification of ϱ-antigenic determinants on the surface, of mouse T-lymphocytes (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 1382-1384 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A monospecific antiserum has been prepared in rabbits against purified ϱ-antigen, a 100,000 mol.wt glycoprotein found on the surface of mouse L-cells. This antiserum has been employed to demonstrate the presence of ϱ-antigenic determinants selectively on the surface of mouse T-, but not B-lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01920194
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  • 10
    Electronic Resource
    Electronic Resource
    Solar flares (1977)
    [s.l.] : Nature Publishing Group
    Nature 267 (1977), S. 87-87 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THERE may be a temptation to regard Svestka's book as an update of Smith and Smith's work of the same title published fourteen years ago. To do so would, however, be to grossly under-estimate the magnitude and success of Svestka's undertaking in this new book. For, firstly, the quantity of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/267087b0
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