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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 40 (1978), S. 255-261 
    ISSN: 1432-0738
    Keywords: Chloromethyl phthalimide ; Oxymethyl phthalimide ; Phthalimide ; Fetus ; Metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Chlormethylphthalimid, Oxymethylphthalimid und Phthalimid werden verhältnismäßig schnell von der Albinoratte resorbiert. Nach oraler Verabreichung von Chlormethyl- und Oxymethylphthalimid an die Muttertiere ist in den Feten nur das Stoffwechselprodukt Phthalimid nachweisbar. Diese Befunde weisen im Zusammenhang mit Stoffwechseluntersuchungen an isolierten Feten auf einen intensiven Stoffwechsel in fetalen Geweben hin. Unterschiede zwischen dünnschichtchromatographischen und 15N-Untersuchungen lassen vermuten, daß Phthalimid durch Öffnung des Imidringes weiter zur Phthalamidsäure metabolisiert wird.
    Notes: Abstract Chloromethyl phthalimide, oxymethyl phthalimide, and phthalimide are absorbed by the albino rat at a comparatively high rate. Only phthalimide, the metabolic product, will be recordable from fetuses, following oral administration of chloromethyl phthalimide and oxymethyl phthalimide to pregnant rats. Those findings, in conjunction with metabolic studies applied to fetuses isolated by caesarian section, appear to suggest the occurrence of an intensive metabolism in fetal tissue. Certain differences established between results of thin-layer chromatography, on the one hand, and 15N studies, on the other, are likely to support the assumption that phthalimide is further metabolised by splitting the imide ring yielding phthalamic acid.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Excited levels of143Eu have been investigated by nuclear spectroscopy methods. We measured γ-rays and conversion electron singles spectra as well asγγ-coincidences from mass separated143mGd sources (108 s) prepared after the irradiation of144Sm with 78 MeVα-particles. In addition in-beam data were obtained by measuringγ-ray singles spectra, angular distributions andγγ-coincidences, following the144Sm(α, 4n+ p, γ) reaction. A level scheme for143Eu comprising 19 levels is proposed, spin assignments or at least restrictions are given. The deduced experimental level scheme can be reproduced semiquantitatively by a generalized decoupling model which takes into account an asymmetric deformation of the core and a variable moment of inertia. Additionally, the results are discussed in the limit of the weak coupling model.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Excitation functions of the compound nuclear reactions191+193Ir,197Au(6Li,xn+yp) forx =3–13 andy=0–2 have been investigated by means of in-beamγ-ray spectroscopy at the 156 MeV6Li beam of the Karlsruhe Isochronous Cyclotron. The beam energy has been varied in the range of 48 to 156 MeV in steps of about 10 MeV by Be-absorber foils in the external beam line. Absolute cross sections have been determined by normalizing the measuredγ-ray intensities to the production cross sections ofK- X-rays in the target. The experimental excitation functions are discussed on the basis of predictions of the preequilibrium (hybrid) model. While in most cases the theoretical calculations fairly well reproduce energy position and shapes of the curves, strong discrepancies in the absolute scale of the cross sections are observed. The theoretical predictions overestimate the (6Li,xn) cross sections by a factor of about 6. Conspicuous anomalies have been detected when comparing the (6Li, xn+1(2)p) reactions with (6Li,xn) reactions. The reactions with emission of one or two protons are considerably enhanced. The discrepancies and anomalies observed are tentatively explained by the influence of direct reaction channels as the6Li break-up, which experimentally proved to be the dominant contribution to the total reaction cross section. The enhancement of the reactions with emission of protons may be a consequence of transfer reactions into highly excited states combined with compound nucleus formation thus implying a cluster effect in preequilibrium emission process.
    Type of Medium: Electronic Resource
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