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  • 1975-1979  (4)
Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 2 (1979), S. 0 
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. The activity of piromidic acid (PA, 8-ethyl-5, 8-dihydro-5-oxo-2-prior lidinopyrido [2,3–d] pyrimidine-6-carboxylic acid) against bacteria in fish was evaluated in vitro and in vivo. In vitro, PA was effective against a wide range of pathogenic bacteria stocked in this laboratory and freshly isolated from fish. PA was active against organisms showing multiple drug-resistance and showed no cross-resistance to chloramphenicol, tetracycline and sulfamonomethoxine. In vivo, orally administered PA was effective against experimental infections with Aeromonas hydrophila and Vibrio spp. in goldfish and eels. The efficacy of PA against these infections was equal to or higher than that of chloramphenicol, and higher than that of tetracycline. Distribution of PA in the Ash was investigated by bioassay and autoradiography. In the bioassay, orally administered PA was easily absorbed and distributed in the blood and tissues of major organs within 1 h after the administration. Peak levels were attained 2 to 4 h post dosing, and no residue was detected in the blood and tissues 48 h post dosing. The results obtained from the autoradiographic investigation in goldfish were similar to those from the bioassay. Therapeutic levels of PA were well tolerated by fish when administered with feed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 2 (1979), S. 0 
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract. The pharmacokinetic and metabolic disposition of piromidic acid (PA) was studied in goldfish orally administered a single dose of 40 mg/kg of PA or 14C-PA with the following results. PA was rapidly absorbed from the alimentary tract and became widely distributed to give maximal organ and tissue levels mostly after 1 h post dosing. Organ and tissue levels of PA as measured by the radioactivity were 1.4–2.2 times as high as those obtained by the bioassay, though their distribution patterns were similar. PA was partly biotransformed to unconjugated antibacterial metabolites, i.e., α-OHPA and β-OHPA and partly to more hydrophilic glucuronides which were excreted into bile. Bioactive metabolites along with PA disappeared almost entirely from the fish within 48 h post dosing. The antibacterial activity of α-OHPA and β-OHPA against major pathogenic bacteria isolated from fish showed two to four-fold greater activity as compared with PA. This pharmacokinetic and metabolic disposition, together with the antibacterial activity of PA and its active metabolites, suggest a possible practical application of PA against bacterial fish diseases.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1110-1112 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An alkaline hemoglobinolytic protease was extracted from the delayed hypersensitivity skin lesions induced by bovine γ-globulin as an antigen in the guinea-pig. The enzyme was heat-labile and inhibited by thiol-blocking reagents. The mol.wt was more than 100,000 and optimal pH around 9.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 11 (1977), S. 1559-1577 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In the present paper, a finite element technique combined with the collocation method is formulated to obtain numerical solutions of integral equations which determine the airload distributions acting on a wing oscillating sinusoidally in a uniform supersonic flow. This technique, which is formulated by the simultaneous use of two integral equations, is shown to be appropriate especially for the low supersonic regions, i.e., for 1 〈 M 〈 1·3, where M is the Mach number of the uniform flow. Although the formulation is made for a sinusoidally oscillating wing, it is obvious that the corresponding formulation for a stationary wing can be derived as a special case of that for the oscillating wing. Problems of determining the airload distributions for stationary as well as sinusoidally oscillating wings are treated, and it is shown that the accuracy of numerical results obtained by the present finite element technique is encouraging.
    Additional Material: 21 Ill.
    Type of Medium: Electronic Resource
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