ISSN:
1432-1246
Keywords:
S-methylfenitrothion
;
Urinary excretion of p-nitro-m-cresol
;
Cholinesterase inhibition and reactivation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect of S-methylfenitrothion on the activity of cholinesterase (ChE) of erythrocytes and plasma was studied as well as the time of its reactivation in rats after peroral administration of 2/3 to 1/100 of LD50. The degradation of S-methylfenitrothion in the organism of rats was evaluated according to the urinary excretion of its metabolite p-nitro-m-cresol. The S-methyl isomer was found to be a more potent inhibitor of cholinesterase than fenitrothion. A remarkable decrease of activity was found even after the administration of 1/100 of LD50. The reactivation of ChE after the administration of 2/3 LD50. took 6 weeks. The excretion was faster and the excreted amounts of p-nitro-m-cresol were significantly higher than they were after fenitrothion administration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01267853
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