ISSN:
1573-2576
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Evidence that macrophages secrete products that contribute to the central role played by these cells in chronic inflammation continues to accumulate. These products include hydrolytic enzymes active at either acid or neutral pH, prostaglandins, several components of the complement system, factors affecting the responses of T and B lymphocytes to mitogens, factor(s) causing increased proliferation and collagen synthesis by fibroblasts, pyrogen, and interferon. There is little information available concerning the effect of inflammatory stimuli on the secretion of these products. In the case of two types of macrophage secretory products, namely lysosomal acid hydrolases and prostaglandins, there is a marked dependence of their release on the nature of the stimuli presented to the cells. Zymosan or antigen-antibody complexes, which show potent inflammatory activity, cause the selective release of acid hydrolases from macrophages in a dose- and time-dependent fashion. These stimuli also cause the release of [3H]arachidonic acid from phospholipids, with resultant synthesis and secretion of prostaglandins. On the other hand, latex particles, which have minimal inflammatory activity in vivo, fail to cause selective release of lysosomal enzymes from macrophages and do not cause prostaglandin biosynthesis and secretion. The major products of arachidonic acid oxygenation produced by macrophages appear to be PGE2 and 6-keto PGF1α, the stable metabolite of PGI2.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00921012
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