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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 8 (1975), S. 680-684 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Environmental science & technology 13 (1979), S. 869-870 
    ISSN: 1520-5851
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Environmental science & technology 12 (1978), S. 900-908 
    ISSN: 1520-5851
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Environmental science & technology 11 (1977), S. 182-188 
    ISSN: 1520-5851
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 98 (1976), S. 4875-4879 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 7 (1977), S. 555-562 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eleven compounds, within hollow capsules of polydimethylsiloxane (Silastic®), have been studied with regard to their rate of release and anti-inflammatory activity in the Adjuvant Arthritic (AA) rat. All of the compounds diffused through the capsule wall to some extent with cortisone acetate exhibiting the slowest and ibuprofen the fastest release rate. Of the eleven encapsulated compounds, only phenylbutazone, indomethacin, ibuprofen and naproxen significantly reduced right and left paw volume below that of control value. Silastic encapsulation increases efficacy of phenylbutazone and indomethacin two to three times over subcutaneous or oral administration. Based on potency and duration of constant release, indomethacin and naproxen should exhibit anti-inflammatory activity in excess of 12 months.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Insectes sociaux 26 (1979), S. 322-342 
    ISSN: 1420-9098
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Resume Les mécanismes d'acroissement du nid deNasutitermes costalis, ont été analysés par l'observation directe et par la photographie d'une colonie prospère, élevée au laboratoire pendant plus de 45 mois. Nous avons enregistré 52 périodes d'accroissement, chacune entraînant une augmentation de 10% du volume du nid. On peut diviser le processus d'accroissement du nid en 3 phases: la phase initiale, la phase de construction, la phase finale. La phase finale aboutit à une surface dont la forme traduit la convergence des premiers efforts de construction pendant la phase initiale d'accroissement. La construction est basée presque entièrement sur des répétitions multiples d'un petit nombre d'éléments architecturaux simples, essentiellement la division, d'un mur en deux embranchements et la réunion de murs voisins au moyen d'un pont. Tout cela se passe sur une “surface active” lisse qui demeure ainsi tout le temps de chaque période d'accroissement. Les intéressantes similitudes entre certains traits architecturaux de l'accroissement du nid deN. costalis, et certaines structures construites «de novo» par des groupes de termites avec une reine et appartenant à trois sous-familles de Termitidae suggèrent que le mode d'accroissement du nid deN. costalis est relativement primitif.
    Notes: Summary The nest expansion behavior ofNasutitermes costalis, a common Neotropical arboreal termite, was analyzed by means of direct and photographic observation of a thriving laboratory colony over a 45-month period. 52 expansion episodes were recorded, each resulting in the addition of as much as 10% to the nest volume. The expansion process can be divided into 3 phases Initiation, Building, and Termination. Termination results in a nest surface whose shape focuses initial building efforts during the Initiation of subsequent expansion. Building consists almost entirely of multiple repetitions of a few simple architectural elements — primarily the branching of one wall into two and the joining of neighboring walls via a bridge — all occurring on a smooth “active surface” which persist throughout each expansion episode. Interesting similarities between certainN. costalis nest expansion architectural features and structures builtde novo by queened termite groups from 3 subfamilies of the Termitidae suggest that this is a relatively primitive mode of nest expansion.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0428
    Keywords: Insulin analogues ; isolated fat cells ; biological potency ; lipogenesis ; inhibition of lipolysis ; combined biological action ; potentiation ; antagonism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper presents a survey of the biological potencies of a variety of naturally-occurring and semi-synthetic insulin analogues and a study of the joint biological action of some of these materials with native insulin. Biological activity was tested on isolated rat fat cells using lipogenesis from glucose as the metabolic index. A brief comparison using inhibition of fat cell lipolysis was included. The results indicated: 1. Analogue potencies varied considerably (0.4–100% insulin activity). Values obtained were mainly confirmatory but included two further B1-modified materials and a tricarbamylated insulin. The results supported previous indications on the relative roles of the A1, B1, and B29 residues of insulin for hormone activity. 2. Analogue bioactivities, whether assessed by stimulation of lipogenesis or inhibition of lipolysis, were similar for the four materials tested in both systems. The response of fat cells with respect to both metabolic indices occurred over a comparable range of insulin concentrations, with half maximal effects at 30–35 pmol 1−1 insulin. 3. The presence of modified insulins appeared to alter the biological action of native insulinin vitro. Small effects of both potentiation and antagonism were identified.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0428
    Keywords: Insulin structure-function ; chemically modified insulin ; proinsulin ; bioactivity of insulin analogues
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Beef insulin, pork proinsulin and four derivatives of beef insulin modified at the A1-B29 site on the molecular surface have been studied. Three derivatives had a synthetic crosslink between the A and B chains. Previous studies with these materials [2, 3 and 5] had demonstrated in vivo bioactivities which were much higher than those displayed in vitro. This paper reports experiments which explain this discrepancy. The analogues were administered at equimolar rates to anaesthetised greyhounds by a priming-dose constant infusion technique and the plasma concentrations achieved were estimated by radioimmunoassay. Proinsulin and the modified insulins were metabolised more slowly than insulin. Biopotency values, which related fall in plasma glucose concentration to the total administered dose of analogue, agreed broadly with published results of conventional in vivo bioassays. On the other hand, calculation of potency in relation to the serum concentration of analogue actually achieved, yielded results which agreed more closely with in vitro assay data. We conclude that for these analogues, reported discrepancies between in vitro and in vivo biopotencies can be largely explained by the different rates at which these materials are metabolised.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0428
    Keywords: Iodoinsulin ; insulin metabolism ; insulin analogues ; biological activity ; tracer insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin, specifically substituted at the PheB1 position with 3,5-diiodotyrosine, has been tested in several biological and immunological systems. Immunoreactivity was assessed using antisera specific for different parts of the insulin molecule. Biological activity in vitro was estimated on isolated rat fat cells. In vivo bioactivity (hypoglycaemia) and metabolism (metabolic and urinary clearance rates, half-life, apparent distribution space) were measured by infusion of the material into greyhounds. The results indicated that this B1-labelled insulin preparation was biologically fully active and, unlike randomly labelled preparations of iodoinsulin, was metabolised with kinetics indistinguishable from those of the unlabelled hormone. We suggest that this material is a valid tracer for insulin, fulfilling the criteria of high specific activity and biological identity to the native hormone.
    Type of Medium: Electronic Resource
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