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  • 1
    Electronic Resource
    Electronic Resource
    107. Colon-Nahttechnik : Einreihige Naht (1978)
    Springer
    Langenbeck's archives of surgery 347 (1978), S. 601-604 
    Details
    ISSN: 1435-2451
    Keywords: Colon Anastomosis ; Suture ; single-layer (-row) ; Colon-Anastomose ; Nahttechnik ; einreihige Naht
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die klinische Gegenüberstellung zweier Patientenkollektive mit ein- und zweireihiger Colon-Nahttechnik ergab für Patienten mit einreihiger Anastomose eine statistisch signifikant niedrigere Komplikationsrate. Im Tierexperiment zeigte die zweireihige Naht einen protrahierten Heilverlauf, eine verzögerte Revascularisierung, intramurale Absceß- und stenosierende Wulstbildung mit Störung der Darmmotilität. Diese Störungen fehlen bei der einreihigen Naht, deren Prinzip eine „Primärheilung” ermöglichte.
    Notes: Summary Comparison of two groups of patients with different anastomosis techniques (622 large-bowel resection) demonstrates a lower rate of complications with the single-row anastomosis. These observations were proved in dogs and rats. The double-row suture prolonged the healing process, delayed revascularization, and led to the formation of intramural abscess and stenotic intraluminal roll building. These problems were not observed in single-row anastomosis, which is designed to promote faster healing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01579400
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  • 2
    Electronic Resource
    Electronic Resource
    228. Abdomino-cervicale Magentransposition (1979)
    Springer
    Langenbeck's archives of surgery 349 (1979), S. 579-579 
    Details
    ISSN: 1435-2451
    Keywords: Esophagus cancer ; Pharyngogastromy ; Endoscopy ; Manometry ; Oesophaguscarcinom ; Abdomino-cervicale Magentransposition ; Endoskopie ; Manometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zwischen 1970 und 1978 wurden 76 Patienten mit Oesophaguscarcinom operativ behandelt. Bei 12 Kranken führten wir eine einzeitige, retrosternale Magentransposition als Oesophagusersatzplastik durch. 9 Patienten dieser Gruppe konnten über annähernd 2 Jahre klinisch, endoskopisch und manometrisch nachuntersucht werden. Die Magentransposition erwies sich als ein technisch relativ einfaches Verfahren mit guten funktionellen Ergebnissen.
    Notes: Summary This report concerns our experience in the treatment of 76 patients with carcinoma of the esophagus. 12 of these underwent one-stage pharyngogastrostomy. 9 patients were followed up postoperatively. The investigated parameters were: clinical status, endoscopic and manometric findings. In conclusion: this procedure was found to be a good practicable method with promising functional results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01729688
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  • 3
    Electronic Resource
    Electronic Resource
    Morphine and β-endorphin inhibit release of noradrenaline from cerebral cortex but not of dopamine from rat striatum (1978)
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 559-561 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Male rats of 150 to 200 g were killed by decapitation. Slices of 0.3 mm thickness were obtained from the rat corpus striatum and occipital cerebral cortex with a Mcllwain tissue chopper. The slices were transferred to the incubation medium in an open lucite cylinder with a nylon mesh fitted to the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/271559a0
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  • 4
    Electronic Resource
    Electronic Resource
    Presynaptic receptors (1978)
    [s.l.] : Nature Publishing Group
    Nature 275 (1978), S. 479-480 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE classical picture of events at nerve endings and synapses has been modi-fled over the past few years by accumulating evidence for the existence of presynaptic receptors for neuro-transmitters, in addition to the classical postsynaptic receptors which mediate the response of the effector organ ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/275479b0
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  • 5
    Electronic Resource
    Electronic Resource
    Possible role of cyclic nucleotides in regulation of noradrenaline release from rat pineal through presynaptic adrenoceptors (1978)
    [s.l.] : Nature Publishing Group
    Nature 274 (1978), S. 76-78 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] For transmitter release studies we used a previously described technique13. Male rats (160-200 g) were killed by decapitation and their pineal gland removed immediately. For each experiment four pineals were placed in an open lucite cylinder with a piece of nylon mesh fitted to the bottom. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/274076a0
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  • 6
    Electronic Resource
    Electronic Resource
    Physiological significance of α-adrenoceptor-mediated negative feedback mechanism regulating noradrenaline release during nerve stimulation (1977)
    [s.l.] : Nature Publishing Group
    Nature 265 (1977), S. 648-650 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In tissues where the effector organ's responses are mediated by a adrenoceptors, block of the presynaptic a receptors enhances noradrenaline release by nerve stimula-lation, but decreases the responses by blockade of the postsynaptic receptors2,6. On the other hand, for tissues in which the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/265648a0
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  • 7
    Electronic Resource
    Electronic Resource
    Stereoselectivity in the metabolism of 3H-noradrenaline during uptake into and efflux from the isolated rat vas deferens (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 299 (1977), S. 225-238 
    Details
    ISSN: 1432-1912
    Keywords: Stereoselective metabolism of noradrenaline ; Neuronal efflux ; Cocaine ; Phenoxybenzamine ; Rat vas deferens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The metabolism of 3H-(-)- and 3H-(±)-noradrenaline (NA) was studied in the isolated rat vas deferens either under conditions of uptake or of efflux of the amine. Any differences obtained between 3H-(-)-and 3H-(±)NA as substrate were interpreted as being a reflection of differences between the two isomers of the amine. 2. Uptake experiments (0.13 μM; 7.5 min) showed that neuronal mechanisms of amine disposition prevail over extraneuronal ones. Thus, most of the metabolites of 3H-NA formed during incubation with the amine (including the O-methylated products) were of neuronal origin. The acid deaminated metabolite 3,4-dihydroxymandelic acid (DOMA), tended to be much better retained by the tissue than the neutral deaminated metabolite, 3,4-dihydroxyphenylethyleneglycol (DOPEG). While neuronal uptake exhibited no stereoselectivity, a pronounced stereoselectivity was found for monoamine oxidase (MAO) [(-)NA〉 (+)NA] as well as for the enzymes which are in series with MAO, namely, aldehyde reductase and aldehyde dehydrogenase [(-)DOPEG〉 (+)DOPEG; (-)DOMA 〈(+)DOMA]. 3. After about 2 h of washout, the efflux of radioactivity from the tissue [which was previously incubated for 30 min with 1.2 μM of either 3H-(-)- or 3H-(±)NA] originated from one neuronal compartment with no stereoselectivity of the rate constant for the efflux of total tritium. The rate-limiting step for the neuronal efflux of tritium resided either in the net efflux of amine from the storage vesicles (normal tissues) or in the net efflux across the axonal membrane (tissues with the amine metabolizing enzymes inhibited). The effects of cocaine and phenoxybenzamine on the neuronal efflux of tritiated compounds strongly depended on the intraneuronal distribution of the 3H-amine. The results indicate that cocaine has only one site of action (neuronal uptake), while phenoxybenzamine exerts reserpine-like as well as cocaine-like effects. 4. The neuronal efflux of tritium from normal tissues preloaded with 3H-(-)- or 3H-(±)NA consisted mainly of amine metabolites (90% of the total; most of this was DOPEG). Since after 2 h of washout the tissue contained hardly any metabolites, these metabolites did not represent pre-formed metabolites (formed during the period of preloading) but newly formed metabolites resulting from the catabolism of the neuronally stored amine. This catabolism was brought about through the activity of presynaptic enzymes and was stereoselective in that more DOPEG, less DOMA and less O-methylated metabolites were formed from (-)-than from (+)NA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500315
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  • 8
    Electronic Resource
    Electronic Resource
    Mechanism of the enhancement in transmitter release from central and peripheral noradrenergic nerve terminals induced by the purified scorpion venom, tityustoxin (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 303 (1978), S. 243-249 
    Details
    ISSN: 1432-1912
    Keywords: Noradrenaline release ; Tityustoxin ; Nictitating membrane ; Hypothalamus ; Cerebral cortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the isolated nerve-muscle preparation of the cat nictitating membrane exposure to 0.04 μM of the scorpion venom tityustoxin (TsTX) increased significantly the overflow of 3H-noradrenaline and the responses elicited by postganglionic nerve stimulation (1200 pulses, 0.5 ms duration, supramaximal voltage). Concentration effect curves to exogenous (-)-noradrenaline were not affected in the presence of this concentration of TsTX. The enhanced release of 3H-noradrenaline obtained during nerve stimulation as well as the increase of the postsynaptic responses observed during exposure to TsTX were more pronounced at 4 Hz than at 20 Hz. The increase in the overflow of noradrenaline observed with the toxin was selective for nerve stimulation since the release evoked by tyramine was not affected by TsTX. TsTX did not increase further the enhancement of 3H-noradrenaline release obtained in the presence of 18 mM tetraethylammonium (TEA). On the other hand, both TsTX and TEA were able to increase further the overflow of 3H-noradrenaline after block of the presynaptic alpha-adrenoceptors with phenoxybenzamine 0.29 or 2.9 μM. In slices of rat cerebral cortex, TsTX 0.04 μM increased 3H-noradrenaline release induced by 10 mM and by 20 mM KCl. The increased release evoked by the toxin was more pronounced for the lower concentration of K+. An increased release of 3H-noradrenaline in the presence of the toxin was also observed in rat hypothalamic slices stimulated with 20 mM K+. The K+ stimulated induced release of 3H-noradrenaline was also increased by 1.8 mM TEA. As shown for the peripheral nervous, system the simultaneous addition of TEA and TsTX did not result in additive effects when compared with the effects of the two agents added separately. Tityustoxin did not modify the metabolic pattern of the neurotransmitter released by K+ from rat hypothalamic slices. It is concluded that TsTX increases the stimulation-induced release of 3H-noradrenaline from both peripheral and central noradrenergic nerve terminals. Tityustoxin appears to act on the nerve terminal by a mechanism similar to that of TEA, an agent known to enhance the amount of noradrenaline released by nerve stimulation by increasing the duration of the action potentials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498050
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  • 9
    Electronic Resource
    Electronic Resource
    Inhibition by dopamine of 3H-noradrenaline release elicited by nerve stimulation in the isolated cat's nictitating membrane (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 289 (1975), S. 179-203 
    Details
    ISSN: 1432-1912
    Keywords: Nerve Stimulation ; Noradrenaline ; Dopamine ; Nictitating Membrane ; Neurotransmission ; α-Adrenoceptors ; Dopamine Receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary After loading the isolated nerve-muscle preparation of the cat nictitating membrane with 3H-(±)-noradrenaline the effects of exogenous dopamine and (-)-noradrenaline were determined on 3H-transmitter overflow elicited by nerve stimulation in the presence of cocaine, 29 μM. Dopamine, 0.20 μM, and (-)-noradrenaline, 0.18 μM, inhibited 3H-noradrenaline release elicited by nerve stimulation at 4 or 10 Hz. Similar results were obtained with apomorphine 0.03 or 0.1 μM. Chlorpromazine, 1 μM, or pimozide, 1 μM, antagonized selectively the reduction in 3H-noradrenaline release obtained with dopamine or apomorphine, without affecting the inhibition obtained with (-)-noradrenaline. Phentolamine, 1 μM, antagonized more effectively the inhibitory effects of (-)-noradrenaline than those of dopamine. Phenoxybenzamine, 0.29 μM, prevented the inhibition of 3H-transmitter overflow obtained with (-)-noradrenaline, dopamine or apomorphine. In the absence of cocaine neither chlorpromazine nor pimozide were able to increase 3H-transmitter overflow during nerve stimulation. In contrast to these results, block of α-adrenoceptors by phentolamine or phenoxybenzamine resulted in an increase 3H-transmitter overflow during nerve stimulation. Inhibition by dopamine of 3H-transmitter overflow appears to be mediated through dopamine receptors probably located in the outer surface of adrenergic nerve endings. These dopamine receptors differ from the prejunctional α-adrenoceptors that mediate the negative feed-back regulatory mechanism for noradrenaline release by nerve stimulation. The prejunctional inhibitory dopamine receptors are not involved in an endogenously mediated regulatory mechanism for noradrenaline release by nerve stimulation under normal conditions. The possibility that these dopamine receptors are involved in the hypotension commonly observed in patients with chronic l-Dopa treatment is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501305
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  • 10
    Electronic Resource
    Electronic Resource
    Evidence for the presynaptic location of the alpha-adrenoceptors which regulate noradrenaline release in the rat submaxillary gland (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 304 (1978), S. 21-26 
    Details
    ISSN: 1432-1912
    Keywords: Submaxillary glands ; Presynaptic receptors ; Potassium ; Phentolamine ; Transmitter release ; Noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifteen days after duct ligation, the wet weight of the rat submaxillary gland was reduced to 40% of the contralateral control. Under these experimental conditions, the noradrenaline (NA) content expressed as μg/g was 1.2±0.1 in the control glands and 1.9±0.2 in the atrophied glands. The accumulation of 3H-NA in the tissue expressed as μCi/gland, did not differ when the atrophied glands were compared with the corresponding controls. Consequently, the uptake and retention of 3H-NA was not modified by the atrophy of the secretory cells of the gland. The spontaneous efflux of radioactivity from normal and atrophied submaxillary glands prelabelled with 3H-NA was similar. The analysis of the metabolic pattern in both experimental groups revealed that in the spontaneous outflow and also during potassium-induced depolarization, the formation of the O-methylated metabolite, 3H-normetanephrine (NMN) was reduced by more than 50% in the atrophied glands. During depolarization induced by K+, a 2-fold increase in the outflow of the deaminated glycol 3H-3,4-dihydroxyphenylglycol (DOPEG) was observed. The effect of phentolamine on the release of radioactivity induced by 60 mM K+ in normal and in atrophied submaxillary gland slices prelabelled with 3H-NA was also investigated. In both experimental groups, the fractional release of total radioactivity induced by K+ was similar. Phentolamine, 3.1 μM, produced a 3-fold increase in the fractional release of radioactivity both in the control and the atrophied glands. These results indicate that the increase of K+-induced release of 3H-NA induced by phentolamine was independent of the presence or absence of the postsynaptic structures. It is concluded that phentolamine increases transmitter release by blocking alpha-adrenoceptors located in the noradrenergic nerve endings of the rat submaxillary gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501373
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