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Digitale Medien

Ultramicroprobe Method for Investigating Mass Transfer through Gas-Liquid Interfaces (1978)

Lee, Young H. ; Tsao, George T. ; Wankat, Phillip C.

s.l. : American Chemical Society

Industrial and engineering chemistry 17 (1978), S. 59-66

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Quelle: ACS Legacy Archives

Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1021/i160065a011

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Digitale Medien

Plasma secretin concentrations in fasting and postprandial state in man (1978)

Chey, William Y. ; Lee, Young H. ; Hendricks, John G. ; [weitere]

Springer

Digestive diseases and sciences 23 (1978), S. 981-988

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ISSN: 1573-2568

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Plasma immunoreactive secretin concentrations were determined in both healthy subjects and patients with duodenal ulcer. The modified radioimmunoassay method could detect significant increases in the plasma secretin concentrations when 0.05 N HCl was infused intraduodenally at a rate of 1.1 and 2.2 ml/min. The mean fasting plasma secretin concentration of 13 normal healthy subjects was 4.4±0.38 pg/ml which was significantly less (P〈0.01) than that of 13 duodenal ulcer patients, 6.9±0.64 pg/ml. In both groups ingestion of a meat-containing meal resulted in significant increase in the plasma secretin concentrations. Recording of pH from proximal duodenum indicated that pH fell periodically below 4.5 during the postprandial period, indicating that only a short segment of proximal duodenum was exposed to acid after meal. The postprandial rise in plasma secretin levels was abolished when antral pH was raised above 5.5 by intragastric infusion of 0.3 N NaHCO3 solution. These observations indicate that although fasting plasma secretin levels are low, the plasma secretin levels increase significantly after ingestion of a meal. This increase appears to be attributable to an increased amount of acid delivered to the proximal duodenum, and patients with duodenal ulcer were found to release more secretin during the postprandial period than normal subjects.