ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The early phase of antigen-dependent triggering of rabbit blood lymphocytes (PBL) is described. Specific activation of PBL by Streptococcal vaccines requires primed lymphocytes from high responder rabbits. B-cell memory is conferred by Ig receptors of both μ and γ chains. Antigen-induced incorporation of leucine and thymidine reach peak values al day 5, with stimulation indices of 10 to 〉 100, closely followed by increases in the number of living cells. A second and less intensive phase of cell proliferation is seen on days 8–11. A large fraction of cells (between 3 and 33%) participates in proliferation. A rough calculation of the average doubling lime of cells during the exponential growth phase gives values of 8–16 h.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1978.tb00447.x
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