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  • 1
    Electronic Resource
    Electronic Resource
    Comparison of the pharmacokinetics of intravenous dl-propranolol in borderline and permanent hypertension (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 387-393 
    Details
    ISSN: 1432-1041
    Keywords: Pharmacokinetics ; dl-propranolol ; borderline hypertensives ; permanent hypertensives ; cardiac output
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In borderline and permanent hypertensives after rapid i.v. injection of dl-propranolol 0.2 mg/kg plasma levels were measured and were fitted to a two-compartment open-model. In borderline patients, characterized by a high basal cardiac output (CO), plasma levels were always lower than in permanent hypertensives. The biological half-life was reduced and the central volume of distribution, volume of distribution at pseudo-equilibrium and total clearance (TC) were markedly increased. In the overall population, there was a significant positive correlation between CO and TC. Rapid achievement of a predetermined plateau in each group constituted experimental proof of the validity of the two-compartment open-model for kinetic analysis of propranolol i.v. If kinetic parameters from permanent hypertensives were applied to borderline hypertensives a lower plateau was obtained. Thus, in so far as β-blockade is related to plasma level of propranolol, an increased intravenous dose may be required in patients with high CO.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563074
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  • 2
    Electronic Resource
    Electronic Resource
    Profiles of Hi (La), Mgii (h and k), Caii (H and K) Lines of an active filament at the limb, with the LPSP instrument aboard the OSO-8 Satellite (1979)
    Springer
    Solar physics 61 (1979), S. 39-59 
    Details
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We scanned the H i Lα, Mg ii h and k, Ca ii K and H lines simultaneously with the LPSP instrument on OSO-8, to investigate the low and moderate temperature regions of an ‘active region filament’. The Lα line is not reversed except for the innermost position in the prominence. Intensity (k/h), (K/H) ratios are respectively 2 and 1.1, indicating that the Mg ii lines are optically thin, and that Ca ii K is saturated, although not clearly reversed. The results obtained during the second sequence of observations (K saturated before Lα for example) indicate that within the size of the slit (1″ × 10″) we are not observing the same emitting features in the different lines. We also observe an important line-of-sight velocity at the outer edge of the feature, increasing outwards from a few km s−1 to 20 km s−1 within 2″. Less than half an hour later, this velocity is reduced to 15 km s−1 while the intensities increase. Full width at half maximum intensities for this component indicate turbulence variations from 22 to 30 km s−1. The observed high velocities at the top of the prominence can be compared with radial velocities that Mein (1977) observed in Hα at the edges of an active filament and interpreted as velocity loops slightly inclined on the axis of the filament.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00155445
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    Paper (German National Licenses)
    Fulltext
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