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Tierexperimentelle und histopathologische Untersuchungen über die Anpassungsvorgänge des Knochens nach der Implantation von „Tragrippen-Endoprothesen“ (1975)

Biehl, G. ; Harms, J. ; Mäusle, E.

Springer

Archives of orthopaedic and trauma surgery 81 (1975), S. 105-118

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ISSN: 1434-3916

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Description / Table of Contents: Zusammenfassung 4 Schäferhunden wurden Endoprothesen nach dem Tragrippen-Prinzip (Mittelmeier) zementfrei implantiert. Sie wurden ab dem 2. postoperativen Tag voll belastet. Nach 21/2 Monaten bestand histologisch noch eine Reparationsphase. Nach 12 Monaten waren die Prothesen durch eine, den Tragrippen gußformartig angepaßte, innere Knochencorticalis fest verankert, die von einer wechselnd breiten fibrösen Bindegewebsmembran bedeckt war. Eine Fremdkörper-Abstoßungsreaktion wie bei der Einzementierung mit Acrylharz oder eine Spongiosierung der Compacta fand sich bei 3 Fällen nicht. Nur bei einem Hund mit primär schlecht aufsitzender Prothese kam es zur Prothesenlockerung; hier zeigte sich nach 5 Monaten noch eine Reparationsphase mit zellreichem Granulationsgewebe und Umbauvorgängen zwischen den Tragrippen, Spongiosierung der Compacta und periostalem Knochenneuanbau. Es werden daraus entsprechende Folgerungen für die Implantation von Tragrippen-Prothesen beim Menschen gezogen.

Notes: Summary Self suspending prostheses with endented shaft were implanted into the hips of 4 dogs (German sheperd dogs) not using bone cement. They were allowed full weight bearing starting on the 2nd post op. day. A reparative stade could still be demonstrated histologically 21/2 months following implantation. At the end of 12 months the prostheses were secured in a newly formed internal cortical bone covered by a membrane of fibrous connective tissue, varying in thickness. A reject reaction or the transformation of the cortical bone into cancellous bone was not demonstrated as it is observed when using acrylic cement. In one dog where the prosthesis was not fitted well we observed lossening of the implant. There was still a reparative stade present following 5 months with multicellular granulative tissue and transforming processes between the suspending dents of the shaft als well a transformation of cortical bone into cancellous bone and periosteal new bone formation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00416154

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Tissue reaction to ceramic implant material (1979)

Harms, J. ; Mäusle, E.

Hoboken, NJ : Wiley-Blackwell

Journal of Biomedical Materials Research 13 (1979), S. 67-87

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ISSN: 0021-9304

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Medicine , Technology

Notes: The biocompatibility of alumina ceramic was tested by means of macrophage cultures, intraperitoneal (i.p.) and intramuscular (i.m.) application of powdered particles in rats, and by implantation of solid samples in the paravertebral muscles and the condylus of femur. No acute cytotoxicity was found in macrophage cultures. The i.p. and i.m. application of powdered particles in the beginning showed a granulocytic reaction, later followed by a histiocytic reaction. Also, the morphological changes in the organs of reticulo histiocytic system (RHS) are shown. In the solid sample implantation, the fibrogenetic stimulus is measured by morphological analysis of the connective tissue membrane around the sample. The importance of the individual cell observation by transmission-electron microscope (TEM) examination is evidenced. The experimental results are compared to the environmental reaction of smaller animal-adapted prostheses and prostheses having been implanted in human patients. Good biocompatibility is confirmed by these investigations; also regarding central position of the macrophages, the environmental reaction due to implant material is shown.

Additional Material: 9 Ill.