Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
24 (1975), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Slices from the guinea-pig olfactory cortex were incubated in the medium containing [14C]glutamate and release of radioactive compounds was subsequently studied in the standard or high potassium media or during repetitive stimulation of the lateral olfactory tract (LOT) while electrical activity of the tissue was monitored. In 50 mm-potassium concentration, the pre- and postsynaptic potentials were completely suppressed and effluxes of total 14C and [14C]glutamate increased. No significant increase in [14C]glutamine was found. When Ca2+ concentration was reduced from 2·4 to 0·12 mm, the postsynaptic potential disappeared and release of [14C]glutamate in 50 mm-potassium decreased to about a third of that in 2·4 mm-Ca2+. Repetitive LOT stimulation enhanced release of total 14C in thinner slices but caused no significant increase in [14C]glutamate efflux. These findings were discussed in relation to the possibility that glutamate is a mediator between the LOT fibres and cortical neurons.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1975.tb11872.x
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