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  • 1975-1979  (7)
  • 1
    Electronic Resource
    Electronic Resource
    Somatostatin in the pancreas, stomach and hypothalamus of the diabetic Chinese hamster (1977)
    Springer
    Diabetologia 13 (1977), S. 463-466 
    Details
    ISSN: 1432-0428
    Keywords: Somatostatin ; diabetic Chinese hamsters ; islet cells ; A1-cells ; glucagon ; insulin ; hypothalamus ; stomach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The inhibitory effects of somatostatin on the release of insulin and glucagon, as well as its localization to the A1-cells (D-cells) of the pancreatic islets, suggest a role of this peptide in carbohydrate metabolism. In the present study we have measured the percentage islet volume, the total weight of the A1-cells and the somatostatin concentration in the pancreas of normal and spontaneously diabetic Chinese hamsters. In addition, the concentration of somatostatin in the stomach and hypothalamus as well as the insulin and glucagon content of the pancreas were evaluated. The percentage islet volume in the normal hamsters was 0.66±0.12, which was in marked excess of that in the diabetic group, 0.38±0.04. Similarly, the total weight of the A1-cells in the controls, 0.17±0.02 mg, was significantly larger than that in the diabetic animals, 0.12±0.02 mg. In agreement with these findings there was also a decreased pancreatic concentration of insulin and somatostatin, whereas the glucagon concentration was in the normal range. Also the stomach of the diabetic hamsters showed a decreased concentration of somatostatin. In the hypothalamus the total content of somatostatin appeared similar in the two groups of animals, but when expressed per mg wet weight this value was also decreased in the diabetic hamsters. These observations strongly suggest that, in the diabetic Chinese hamster, apart from the well-known B-cell deficiency there exists also a decreased functional activity of the somatostatin-producing cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01234497
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Immunochemical Studies of Lipoproteins in Cholestasis (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 4 (1975), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lipoproteins in normal and cholestatic human plasma were studied using crossed immuno-electrophoresis and electroimmunoassay. Crossed immuno-electrophoresis against anti-α-lipoprotein revealed a complex pattern of α-lipoproteins in cholestasis resembling that of α-lipoproteins in a patient with familial deficiency of the enzyme lecithin cholesterol acyl transferase. With anti-β-lipoprotein an absence of pre-β-lipoproteins with normal electropho-retic mobility was noted in crossed immunoelectrophoresis. These observations indicate that false values may be obtained with the use of electroimmunoassay for the determination of lipoprotein concentrations in cholestasis. A method employing crossed immunoelectrophoresis with an intermediate gel for the quantitative determination of lipoprotein X is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1975.tb03803.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Induction of Histamine Release and Desensitization in Human Leukocytes (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 4 (1975), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Histamine release from normal human leukocytes can be induced by anti-IgE or protein A from Staphylococcus aureus. After incubation in buffer at 37°C for various time intervals or repeated washings with buffer, or both procedures, the leukocytes lose most of their reactivity to protein A, whereas the reactivity to anti-IgE is unaltered. Cells deprived of their protein A reactivity can be induced to release histamine by IgG complexed with protein A. Maximal release (23%-81%) from 0.6–1.0 × 107 leukocytes per ml is obtained if the mixture contains 1–2 μg protein A and 8–16 μg IgG per ml. The ratio between protein A and IgG in the most active mixtures is 1:8 or 1:16 on a weight basis, which corresponds to 2–4 IgG molecules per protein A molecule. Heat treatment does not destroy the capacity of IgG to mediate histamine release. Mixtures of protein A and the Fc part of IgG can also initiate the release. Furthermore, it is shown that the protein A—IgG mixture and anti-IgE induce cross-desensitization to each other. This indicates that, like cell-bound IgG, IgG in complex with protein A triggers partially the same reaction sequence as IgE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1975.tb03717.x
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  • 4
    Electronic Resource
    Electronic Resource
    Induction of Histamine Release and Desensitization in Human Leukocytes (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 4 (1975), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Histamine release from normal human leukocytes can be induced by anti-IgE or protein A from Staphylococcus aureus. After incubation in buffer at 37°C for various time intervals or repeated washings with buffer, or both procedures, the leukocytes lose most of their reactivity to protein A, whereas the reactivity to anti-IgE is unaltered. Cells deprived of their protein A reactivity can be induced to release histamine by IgG complexed with protein A. Maximal release (23%–81%) from 0.6–1.0 × 107 leukocytes per ml is obtained if the mixture contains 1–2 μg protein A and 8–16 μg IgG per ml. The ratio between protein A and IgG in the most active mixtures is 1:8 or 1:16 on a weight basis, which corresponds to 2–4 IgG molecules per protein A molecule. Heat treatment does not destroy the capacity of IgG to mediate histamine release. Mixtures of protein A and the Fc part of IgG can also initiate the release. Furthermore, it is shown that the protein A-IgG mixture and anti-IgE induce cross-desensitization to each other. This indicates that, like cell-bound IgG, IgG in complex with protein A triggers partially the same reaction sequence as IgE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1975.tb02686.x
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  • 5
    Electronic Resource
    Electronic Resource
    Induction of Histamine Release and Desensitization in Human Leukocytes (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 4 (1975), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Protein A from Staphylococcus aureus has been found to react with all human leukocyte preparations tested. In 70%, of the experiments the reaction leads to histamine release. Further more, protein A treatment of cells at 37°C both in complete and Ca+2-free medium, results in the inhibition of anti-IgE-induced histamine release in all cell preparations, indicating that protein A and anti-IgE antibodies release histamine from the same cells. This inhibition seems to be due to the blocking or exhaustion of a step in the biochemical pathway, leading to histamine release activated by both protein A and anti IgE. In some cell preparations desensitization but no histamine liberation is induced by protein A. No inhibition occurs if the protein A treatment is performed at 4°C. It is concluded that protein A elicits histamine liberation and desensitization by acting on IgG present on the surface of the basophil granulocytes Treatment of leukocytes at 37°C with anti-IgE antibodies, or F(ab')2 fragments from such antibodies, also results in an inhibition of a subsequent anti-IgE-induced histamine release. Desensitization with low doses of anti-IgE results in an inhibition of the same type as that obtained with protein A. Supraoptimum amounts of anti-IgE or high amounts ill monovalent Fab fragments from anti-IgE immunoglobulin G give an inhibition that could be due to a competition between the sensitizing and the challenging agents for combining with cell-fixed IgE molecules This inhibition is independent of temperature and calcium concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1975.tb02606.x
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  • 6
    Electronic Resource
    Electronic Resource
    Somatostatin content and release of isolated pancreatic islets from obese-hyperglycemic mice (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 127-128 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The somatostatin content in pancreatic islets of obese-hyperglycemic mice was much lower than in the islets of normal mice. Also the release of somatostatin was decreased from the islets obtained from the obese-hyperglycemic mice. Tissue culture for 1 week changed neither the content of, nor the amount of somatostatin released from, the pancreatic islets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01917919
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  • 7
    Electronic Resource
    Electronic Resource
    Symmetric hadron pairs at large transverse momenta as a test of hard scattering models (1979)
    Springer
    The European physical journal 2 (1979), S. 265-277 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The inclusive cross section of hadron pairs produced back-to-back with large transverse momenta is examined in the parton model. It is shown quantitatively that this cross section is determined directly by the hard scattering subprocesses, without being influenced by the internal momentum of the constituents, even for transverse momenta of the order of 2–3 GeV/c. The predictions of the phenomenological quark-quark scattering model and of the quantum chromodynamics model for the back-to-back cross section are compared with recent Fermi-lab data. Predictions are made for the corresponding cross section at ISR-energies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01474671
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