ISSN:
1432-0703
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Energietechnik
,
Medizin
Notizen:
Abstract This study was designed to determine the effect of hexachlorobenzene (HCB) on rat reproduction. Dietary concentrations of 0, 10, 20, 40, 80, 160, 320, and 640 ppm of HCB were fed to Sprague-Dawley rats in a four generation reproduction study. Pregnancy (number of dams whelping/number of dams mated), viability (pups surviving 5 days/pups born alive), and lactation (pups weaned/live pups on day 5 less culls) indices were measured. Body weight gain of pups was monitored. HCB residues were measured in the 21-day-old pups of the F1a and F3a generations. The two highest dietary concentrations were toxic to the F0 generation females and 50% and 20% respectively, died. Sucking pups were particularly sensitive and many died prior to being weaned. The viability index was zero in the F1a and F1b generations for pups from dams fed 320 and 640 ppm of HCB and only 55% for the 160 ppm group. The lactation index decreased from 30% for the F1a and F1b generation pups to 0 for the F2a and F2b generation pups in the 160 ppm group. Also, the lactation index decreased from 93% in the F1a generation to 40% in the F3b generation for the 80 ppm group. Birth, 5-day and 21-day body weights of pups were decreased by treatment. HCB residues accumulated in the pups in a dose-related manner. The relative liver weight and aniline hydroxylase activities were increased in weanlings from dams fed 40 ppm of HCB. No gross abnormalities were observed in the pups.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02220904
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