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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 54 (1976), S. 169-171 
    ISSN: 1432-1440
    Keywords: Blutkörperchensenkungsgeschwindigkeit ; C-reaktives Protein ; Akute-Phase-Proteine ; Methode ; Erythrocyte sedimentation rate ; C-reactive protein ; Acute phase proteins ; Method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary C-reactive protein (CRP) was isolated from pleura exudate of patients with metastasing cancer and added to plasma of healthy blood donors. Only the addition of excessive amounts of CRP (220 mg/ml) caused a notable increase in erythrocyte sedimentation rate. An immunoelectrophoretic method for the simultaneous quantitative determination of CRP together with C 3 or other acute phase reactants is described.
    Notes: Zusammenfassung C-reaktives Protein (CRP) wurde aus dem Pleuraexsudat von Patienten mit metastasierenden Tumoren isoliert und zu dem Plasma von gesunden Blutspendern zugefügt. Nur die Zugabe von extrem hohen Mengen von CRP (220 mg/ml) verursachte eine gewisse Beschleunigung der Erythrozytensenkungsgeschwindigkeit. Außerdem wird eine immunelektrophoretische Methode für die gleichzeitige quantitative Bestimmung von CRP und C 3 oder anderen akute-Phase-Proteinen beschrieben.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 53 (1975), S. 265-273 
    ISSN: 1432-1440
    Keywords: Erythrocyte sedimentation rate ; plasma proteins ; correlation coefficient ; myocardial infarction ; Blutkörperchensenkungsgeschwindigkeit ; Plasmaproteine ; Korrelationskoeffizienten ; Herzinfarkt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Bei 72 Probanden, davon 37 Herzinfarktpatienten wurde der Spearmansche Rangkorrelationskoeffizient von BKS-Geschwindigkeit und den Konzentrationen von zwanzig einzelnen Plasmaproteinen bestimmt. Die höchsten Korrelationskoeffizienten wurden in der Reihenfolge ihrer Nennung gefunden für: Fibrinogen, Orosomukoid, α-2-Makroglobulin, α-1-Antitrypsin, Coeruloplasmin, Ig M. Die Summe der molaren Konzentrationen von Fibrinogen, α-2-Makroglobulin und Ig M wies gegenüber der BKS-Geschwindigkeit die engste Korrelation auf. 2. Die Aufschlüsselung des untersuchten Kollektivs nach der Diagnose ergab, daß für viele Plasmaproteine der Grad der Korrelation zur BKS-Geschwindigkeit wesentlich von der Zusammensetzung des untersuchten Patientengutes abhängt. Die Gruppe der Patienten mit Herzinfarkt, mit Pneumonie und mit Neoplasma wiesen jeweils deutlich verschiedene Korrelationsspektren auf, denen offenbar krankheitsspezifische Änderungen der Konzentrationen der Plasmaproteine zugrunde liegen. 3. Bei 4 Herzinfarktpatienten wurden über einen Zeitraum von 26 Tagen die Änderungen der Plasmaproteinkonzentrationen im Zusammenhang mit der BKS-Geschwindigkeit verfolgt.
    Notes: Summary 1. Spearman's rank correlation coefficient between erythrocyte sedimentation rate and the concentration of twenty individual plasma proteins was determined in 72 persons including 37 patients with recent myocardial infarction. The highest correlation coefficients with ESR could be demonstrated in the following proteins: fibrinogen, α-1-acid-glycoprotein, α-2-macroglobulin, α-1-antitrypsin, coeruloplasmin, Ig M. The closest correlation with ESR was found, when the molar concentrations of fibrinogen, α-2-macroglobulin and Ig M were summed up. 2. Subdivision of the examined group of patients according to their diagnosis showed that the degree of correlation with ESR in many plasma proteins essentially depends on the composition of the studied group of patients. The patients with myocardial infarction, with pneumonia and those with neoplasma all showed distinctly different patterns of correlation. These obviously reflect underlying changes in the concentrations of the studied proteins, that seem to be specific to the respective disease. 3. In 4 patients with myocardial infarction the changes in plasma protein concentrations together with ESR were followed over a period of 26 days after the infarction.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 53 (1975), S. 385-389 
    ISSN: 1432-1440
    Keywords: Coronary heart disease ; myocardial infarction ; risk factors ; erythrocyte aggregation ; cell volume distribution ; Koronare Herzkrankheit ; Herzinfarkt ; Risikofaktoren ; Erythrocytenaggregation ; Erythrocytenvolumenverteilung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Die in-vitro-Messung der Erythrocytenaggregation wurde so verbessert, daß der Variationskoeffizient auf ±14,2% herabgedrückt wurde. 2. Mit der verbesserten Methode konnten die früheren Befunde statistisch hochsignifikant gesichert werden, daß sonst gesunde starke Raucher einen wesentlichen höheren Erythrocytenaggregationswert aufweisen als Nichtraucher. 3. Es wurde auch bei anderen Risikofaktoren koronarer Herzerkrankungen nachgewiesen, daß sie zu einer Erhöhung des Aggregationswerts der Erythrocyten führen. Insbesondere konnte dies bei Hypercholesterinämie nachgewiesen werden. 4. Mehrere Risikofaktoren beim gleichen Patienten bewirken einen überadditiv hohen Aggregationswert der Erythrocyten.
    Notes: Summary 1. The vitro test for red blood cell aggregation has been improved, the coefficient of variation was decreased to 14.2. 2. By the improved method the earlier findings were confirmed with high statistical significance that heavy smokers have a significantly higher red blood cell aggregation value in comparison with nonsmokers. 3. It could be shown that other coronary risk factors, especially hypercholesterolaemia, increase the aggregation value too. 4. The aggregation of red blood cells increases in the presence of several coronary risk factors in the same patient to higher values than expected from the addition of the aggregations caused by single risk factors.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1017
    Keywords: Electric field ; Magnetic field ; Suspended particle ; Magnetic sensitivity ; Organism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract We observed that particles, suspended in an electrolyte and brought into crossed magnetic and electric fields of low intensities, will deviate in the central part of the electrophoresis chamber of a standard Zeiss Cytopherometer with a component vertical to both fields. The direction and magnitude, however, were sharply at variance with what would be expected by the action of the Lorentz force (EMF) on the surface of the particles. The magnitude of the deviation depends upon the magnetic and electric field strength, the ion concentration of the suspension medium and the geometry of the chamber. The movement of the particles is due to streaming of the electrolyte which is mainly caused by inhomogeneities of the electric field in the electrophoresis chamber. The magnitude of the effect is high enough to occur under physiological conditions. Magneto-electrophoretic streaming might eventually act as a transducer mechanism which could explain the ability of some animals to orientate themselves in the geomagnetic field.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Virus-induced human leukocyte interferon did not contain demonstrable MIF activity and MIF-rich fractions produced by concanavalin A stimulation of human lymphocytes lacked interferon activity.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 33 (1976), S. 133-134 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0584
    Keywords: Carrageenan ; Inflammation ; Fibrinogen ; Fibrinopeptide ; Rat paw oedema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The acute inflammatory rat paw oedema induced by subplantar injection of carrageenan was significantly inhibited by intraperitoneal injection of rat fibrinogen, intraperitoneal and intracardial injection of fibrinopeptides A and B. In contrast the fibrin split products derived from plasmin digestion proved to be ineffective.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 37 (1978), S. 103-105 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 37 (1978), S. 285-286 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 38 (1979), S. 93-101 
    ISSN: 1432-0584
    Keywords: Lymphokine ; Makrophagen-Migrationshemmfaktor (MIF) ; Biochemische Parameter ; Biologische Funktion ; Klinische Bedeutung ; Lymphokines ; Macrophage migration inhibitory factor (MIF) ; Biochemical parameters ; Biological function ; Clinical relevance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The first isolation and characterization of a lymphokine, the human MIF (MSF), and the availability of a specific MIF (MSF)-antibody provide an opportunity to establish a new parameter for detection of cellular immune mechanisms in various clinical situations. The precise estimation of quantitative amounts of MIF by sensitive immunochemical techniques could gain new insights into the pathogenesis of a number of clinical disorders. In addition, the exact detection of quantitative amounts of MIF in body fluids could have prognostic value.
    Notes: Zusammenfassung Die erste Isolierung und Charakterisierung eines Lymphokins, des menschlichen MIF (MSF), und die Gewinnung eines spezifischen MIF (MSF)-Antikörpers eröffnen die Möglichkeit, neue Parameter für die Bestimmung zellulärer Immunmechanismen bei verschiedenen klinischen Situationen zu gewinnen. Die genaue quantitative Bestimmung mit empfindlichen immunochemischen Techniken könnte einen Einblick in die Pathogenese verschiedener klinischer Erkrankungen ermöglichen. Zusätzlich könnte der quantitativen Bestimmung von MIF in Körperflüssigkeiten eine prognostische Bedeutung zukommen.
    Type of Medium: Electronic Resource
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