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  • 1
    Electronic Resource
    Electronic Resource
    Aneurysm surgery above the eighth decade (1979)
    Springer
    Acta neurochirurgica 47 (1979), S. 31-36 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A series of nine patients over 70 years of age with saccular aneurysms, operated on by direct surgery, is reviewed in order to discuss aneurysm surgery in older patients. The median age of the patients was 74 years, and the median interval from haemorrhage to surgery was 18 days. Operative mortality was 11%, and morbidity was 33%. Because of arteriosclerosis round the aneurysm neck and parent artery, special considerations for surgical treatment on the older patients are required.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01404660
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Factors responsible for immune resistance to L1210 murine leukemia in hyperimmune mice (1979)
    Springer
    Cancer immunology immunotherapy 7 (1979), S. 123-129 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The serum of mice hyperimmune to L1210 leukemia was cytotoxic to L1210 cells and, to a much lesser extent, to P388 cells in the presence of complement. However, it did not suppress in vitro growth of L1210 cells, nor did it endow a recipient mouse with immunity to inoculated L1210 cells. This indicates that the serum did not play a significant role, if any, in immune protection of hyperimmune mice. Spleen and peritoneal exudate cells of hyperimmune mice suppressed the in vitro growth of L1210 but not of P388 cells. This is consistent with the fact that hyperimmune mice did not survive the inoculation of P388 cells. The immunocytes failed to suppress the in vitro growth of L1210 cells when preincubated with anti-Thy-1.2 antisera and complement. This, together with the finding that cell populations not adherent to a plastic dish suppressed in vitro growth of L1210 cells, indicates that T cells of immune spleen and peritoneal exudate cell populations were the effectors that suppressed in vitro growth of L1210 cells. Hyperimmune mice lost their immune protection in vivo following the administration of anti-thymocyte antisera, but not with carrageenan or silica, which resulted in the lethal growth of the inoculated L1210 cells. This indicates that T cells were in vivo effectors in immune protection. Hyperimmune spleen T cells endowed a recipient with immunity to L1210 leukemia when transferred in vivo. This confirmed the above results and suggests the applicability of immune cells in an adoptive immunotherapy approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00205334
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A field survey on the health status of workers in dye-producing factories (1977)
    Springer
    International archives of occupational and environmental health 39 (1977), S. 219-235 
    Details
    ISSN: 1432-1246
    Keywords: Anaemia ; Aromatic nitro-amino compounds ; Diazo-positive urinary metabolites ; Heinz bodies ; Hepatotoxicity ; Methemoglobinaemia ; Methemoglobin reductases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Health status of the workers in dye-producing plants were examined repeatedly in winter and in summer. The items studied cover 1) diazo-positive metabolites in urine 2) methemoglobinaemia, Heinz bodies, methemoglobin reductases and anaemia, and 3) liver function. The urinary diazo-positive metabolite level in the exposed was higher than that in the non-exposed and marked a conspicuous increase in summer as compared in winter, indicating significant intake of the aromatic nitro-amino compounds, while no significant methemoglobinaemia, Heinz bodies, anaemia nor disturbed liver function was observed in any group of the examinees. The results were discussed in connection with the dose-effect relationship, and compared with the experiences in the past.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409368
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Chronopharmacological study of neuroleptics (1979)
    Springer
    Psychopharmacology 63 (1979), S. 131-135 
    Details
    ISSN: 1432-2072
    Keywords: Haloperidol ; Circadian rhythm ; Sedative effect ; Antiapomorphine effect ; Dopamine receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The circadian fluctuation of sedative effect of haloperidol was experimentally studied, as part of the series of investigations on circadian fluctuation of the effect of neuroleptics. Haloperidol of various doses was administered at various times during the day to rats which had been housed with strictly controlled lighting schedule and room temperature. It was shown that sedative effect of haloperidol was significantly affected by the time of day of administration, that is, there is a circadian fluctuation, and also that the variation pattern changed with different doses of this drug. In order to study the mechanism underlying this circadian fluctuation, time course changes in plasma and brain concentrations of the drug were measured. No significant difference in the concentrations was observed among the different times of administration. It was thus suggested that the circadian fluctuation of sedative effect of haloperidol might be due to the circadian rhythm of brain susceptibility to the drug. Antiapomorphine action of haloperidol was then examined using stereotyped behavior of the rat as an index. The result indicated the presence of the circadian fluctuation of antiapomorphine action which was in a pattern similar to the variation of the sedative effect of haloperidol. Based on the experimental results thus obtained, the generating mechanism for the circadian fluctuation of sedative effect of haloperidol was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429690
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    Paper (German National Licenses)
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