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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 16 (1979), S. 431-433 
    ISSN: 1432-1041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 10 (1976), S. 367-372 
    ISSN: 1432-1041
    Keywords: Pharmacokinetics ; pancuronium ; neuro-muscular blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma concentrations of pancuronium bromide have been studied in seven surgical patients following a 6 mg intravenous bolus injection of the drug for neuromuscular blockade. Concurrently, evoked muscle twitch response was monitored for each patient as a measure of the pharmacodynamic effect of the drug. The plasma decay curve for pancuronium was found to be biphasic and after rigorous statistical analysis the data were interpreted according to a 2-compartment open model. The half-life of the β-phase varied between 89.5 and 161.5 min. The apparent volume of distribution of the central compartment ranged from 62.9 to 145.5 ml/kg and the plasma clearance from 57.6 to 187.3 ml/min. At the first sign of recovery from neuro-muscular blockade the mean pancuronium plasma level was found to be 0.218 mcg/ml. The mean duration of action as measured from time of onset of paralysis to 20% recovery was 83.4 min with the plasma level at 20% being 0.169 mcg/ml corresponding to 45.4% of dose remaining to be eliminated from the body.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 12 (1977), S. 23-29 
    ISSN: 1432-1041
    Keywords: Pancuronium ; renal transplant ; single and multiple dosing ; plasma levels and twitch response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma concentrations of pancuronium following single dose administration in six patients, and following multiple dose administration in four patients, all undergoing renal transplantation surgery, were measured using a fluorimetric method. A two-compartment open model was used in the pharmacokinetic analysis of the data. Comparison of the pharmacokinetic findings with data previously obtained for patients undergoing elective surgery but having normal renal function indicated that the clearance of the drug was reduced significantly in the patients with renal failure, and that in these individuals the half-life was increased significantly. Measurement of the evoked mechanical twitch response concurrently with plasma concentration monitoring of pancuronium confirmed that the prolongation of half-life in the patients with renal failure was often but not always associated with an extended duration of neuromuscular blockade and furthermore that the rate of recovery from block might also be prolonged. The clinical implications of these findings are discussed.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 255 (1975), S. 687-689 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The results of other anisotropy measurements are also shown in Fig. 1. Some of these1"3 give upper limits only; others3"5 do indicate some anisotropy. But the Hobart measurement4 is at low energies for which solar modulation effects are not negligible, and the residual solar waves obtained at ...
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Based on the data of the high-apogee satellite Prognoz-3, the April 29–30, 1973 solar particle event is analysed. The event's complex energetic particle, interplanetary magnetic field and solar wind plasma properties are discussed. The unusual behaviour of solar particles up to energies ≈100 MeV can well be explained in terms of the interaction with an interplanetary shock wave system passing the Earth. Assuming that the structure of the interplanetary shock wave system is similar to that considered first by Parker (1961) and Gold (1959) and reviewed later by Hundhausen (1972) and Dryer (1974, 1975), the main characteristics of the energetic particle fluxes, solar wind and interplanetary magnetic field can be understood.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Analysis mathematica 3 (1977), S. 131-139 
    ISSN: 1588-273X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Статья посвящена обо бщению неравенства Меньшова-Радемахера. Условие ортогональн ости заменяется усло вием (4), т.е. предполагается, что с уществует функционалh, зависящ ий от совместного рас пределения случайных величинX m+1 , Х m+2 ,..., Х m+n , который субаддити вен в смысле условия (5) и удовлетворяет услов ию (4). Из этих допущений выводится неравенство вида (6). В ч астном случае Ф(х)=¦х¦p(р≧1) в нер авенстве (6) мы имеемB Φ (y)=y p . Во второй части стать и из указанных нераве нств выводятся некоторые усиленные законы больших чисел. Типичн ым результатом являе тся следующий. Пусть р〉1 и x 1, Х2,... —после довательность случа йных величин. Если для всех m≧0, n≧1 выполнены неравенс тва $$E\left( {\left| {\mathop \Sigma \limits_{i = m + 1}^{m + n} X_i } \right|^p } \right) \leqq h(F_{m,n} )$$ где функционал h(F m,n )удо влетворяет условию (5) u $$h(F_{0,n} ) = O\left( {\frac{{n^p }}{{(\log n)^{p + 1} (\log \log n)^2 }}} \right)(n \to \infty )$$ , mo $$P(S_n /n \to 0) = 1$$ .
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Analysis mathematica 4 (1978), S. 53-59 
    ISSN: 1588-273X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract Доказывается следую щая теорема Пусть φ(t) — неубывающая па [0,+∞] непрерывная сле ва функция, φ(0)=0.Пусть дале е $$\Phi (t) = \mathop \smallint \limits_0^t \varphi (s) ds u \mathop {sup}\limits_{t 〉 0} \frac{{t\varphi (t)}}{{\Phi (t)}}〈 \infty $$ .Если X 1 Х 2, ... —такая последовательность случайных величин, что $$E\left( {\Phi \left( {\left| {\mathop \sum \limits_{i = m + 1}^{m + n} X_i } \right|} \right)} \right) \leqq g^\alpha (F_{m, n} ) (m \geqq 0, n \geqq 1)$$ , где α〉1, а g(Fm,n) — некоторый функционал, зависящи й от совместного распред еления Xi и удовлетворяющий ус ловиям $$g(F_{m, n} ) + g(F_{m + k, n} ) \leqq g(F_{m, n + k} ) (m \geqq 0, n \geqq 1, k \geqq 1)$$ ,k ≧1), moсправедливы оценки $$E\left( {\Phi \left( {\mathop {\max }\limits_{1 \leqq k \leqq n} \left| {\mathop \sum \limits_{i = m + 1}^{m + n} X_i } \right|} \right)} \right) = Kg^\alpha (F_{m, n} ) (m \geqq 0, n \geqq 1)$$ ,где множитель К конеч ен и не зависит от т. п.
    Type of Medium: Electronic Resource
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