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  • 1
    Electronic Resource
    Electronic Resource
    Age-dependent morphological changes in the seminal colliculus in male mice (1979)
    Springer
    Anatomy and embryology 158 (1979), S. 1-12 
    Details
    ISSN: 1432-0568
    Keywords: Neonatal mouse seminal colliculus ; Developmental changes ; Scanning electron microscopy ; Ruffled cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The developmental changes in the seminal colliculus of male mice were studied by light and scanning electron microscopy. The epithelium of the mouse seminal colliculus is transformed to the mature epithelium between 20 and 25 days of age, while the transformation of the remaining urethral wall occurred from 5 to 10 days of age. During the process of this epithelial transformation at the seminal colliculus unusual structures, including prominent epithelial proliferations and protrusions, were observed in the area adjacent to the ejaculatory duct openings and the ventral area of the upper medial region of the seminal colliculus in 15-day-old mice. In these unusual structures, three types of cells were recognized by their surface characteristics: cells which had distinct borders and ruffled cell surfaces with microridges; cells which had distinct borders and flat or slightly ruffled cell surfaces with many short microvilli, and small cells which had rounded cell surfaces with many long microvilli. In the remaining area of the seminal colliculus, two types of cells were distinguished: those which had flat or slightly rounded cell surfaces with many short microvilli and those cells with many long microvilli similar to the ones in the previously described area. In 25-day-old mice, the unusual protruding structures were not observed, but some cells with ruffled surfaces were still seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315948
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  • 2
    Electronic Resource
    Electronic Resource
    Induction of estrogen-independent persistent vaginal cornification in cyproterone acetate (CA)-induced feminized male mice (1977)
    Springer
    Anatomy and embryology 151 (1977), S. 119-125 
    Details
    ISSN: 1432-0568
    Keywords: Feminized male mice ; Antiandrogen ; Neonatal estrogen treatment ; Estrogen-independent persistent vaginal cornification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pregnant ICR/JCL mice were treated with 6 mg of cyproterone acetate (CA) from days 14 to 20 of pregnancy to feminize male offspring. Feminized males delivered on day 20 of pregnancy by cesarean section were castrated the same day, injected with estradiol-17β(E2) or sesame oil from the day of delivery (=day 1) to day 10 and sacrificed on day 60. In oil-injected feminized males, the vaginal epithelium was atrophic and did not show cornification. In feminized males given 20 μg E2 neonatally, the vaginal epithelium exhibited well-differentiated stratified squamous organization, but was not cornified in seven out of the nine mice of this group. In the mice treated with 50 μg E2, persistent cornification was recognized most frequently in the posterior two-thirds of the vaginal epithelium which is considered to originate from the which may contain the epithelial cells of müllerian duct was low. These results provide supporting evidence for the possible participation of epithelial cells which come from the urogenital sinus in the development of estrogen-independent persistent vaginal cornification in neonatally estrogenized mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297475
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  • 3
    Electronic Resource
    Electronic Resource
    Microtubules observed within the cistern of RER in neurons of the aged dog (1978)
    Springer
    Acta neuropathologica 44 (1978), S. 155-158 
    Details
    ISSN: 1432-0533
    Keywords: RER ; Microtubules ; Neuronal inclusion ; Ageing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-seven randomly selected dogs ranging from 1 month to 16 years of age were examined light- and electron microscopically. An intraneuronal inclusion body was found in 13 of 27 cases. In particular, 12 of 13 positive cases were elderly dogs of over 8 years of age. The inclusions showed amphophilic violet color with H.-E. stain and measured 3–42 μm in diameter. Histochemically, they were thought to be a glycoprotein complex. The inclusions were characterized by the electron microscopy and composed of aggregated cistern of RER closely packed with tubular structures. The individual tubules measured about 24 nm in diameter and had 11–13 subunits forming their walls. These constituents were very similar to those of microtubules. The occurrence of the inclusion bodies showed an apparent age-dependency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691484
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  • 4
    Electronic Resource
    Electronic Resource
    Lafora-like bodies in a cat (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 55-58 
    Details
    ISSN: 1432-0533
    Keywords: Lafora-like bodies ; Morphogenesis ; Glycogen metabolism ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lafora-like bodies in an 8-year-old cat were studied light and electron microscopically and histochemically. In addition to Lafora-like bodies composed of branching filaments, glycogen granules and electron-dense materials, abnormal accumulations of glycogen granules attracted attention. The most remarkable features were the developmental processes of the branching filaments originating directly from glycogen granules. Lafora-like bodies in the present study showed ultrastructural, histochemical, and enzymatic similarities to those described in the previous reports in Lafora's disease, glycogenosis and other cases. From these results, a certain disturbance of the glycogen metabolism is considered to be probably related to the productive mechanism of Lafora-like bodies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691791
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  • 5
    Electronic Resource
    Electronic Resource
    Correlative studies of axonal spheroids and Lafora-like bodies in aged dogs (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 77-81 
    Details
    ISSN: 1432-0533
    Keywords: Aging ; Nucleus gracilis ; Conus medullaris ; Intra-spheroidal Lafora-like bodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The gracile nucleus and conus medullaris, the sites of predilection for spheroids and Lafora-like bodies, were examined light and electron microscopically in 91 dogs ranging from 1 month to 19 years of age. The number of both structures showed a tendency to increase with age. Spheroids have already been found in younger dogs before the appearance of Lafora-like bodies. In the aged dog, intra-spheroidal Lafora-like bodies were occasionally observed. Correlative studies may yield clues on the pathogenesis of aging phenomena in the CNS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691796
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Lafora-like inclusion bodies in the CNS of aged dogs (1978)
    Springer
    Acta neuropathologica 44 (1978), S. 217-222 
    Details
    ISSN: 1432-0533
    Keywords: Lafora-like inclusion bodies ; Aging ; Dog ; High incidence ; Comparative neuropathology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty randomly selected dogs, arranged into three groups according to age, were examined light and electron microscopically. Lafora-like inclusion bodies were found in all cases of aged dogs without neurological signs. They appeared as PAS positive, round bodies measuring up to 15μm in diameter. Typically they had central cores and radiating peripheral lines. Electronmicroscopically, the inclusions consisted of irregularly clustered, short branching filaments measuring about 80–120 Å in diameter or of electrondense homogeneous or granular central cores with filamentous peripheral areas and located both in the perikarya and neuronal processes. The inclusions were disseminated all over the brain and spinal cord. The thalamic nuclei, a circumscribed area dorsal to the aqueduct, and the molecular layer of the superior colliculus were the most severely affected. The frequency of the inclusions showed age-dependency; the inclusions were not found in dogs younger than 2 years, but were extensive in all dogs of more than 8 years of age. The occurrence of the inclusions may therefore represent an age-dependent phenomenon. The relationship between the present findings and Lafora's disease is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691070
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  • 7
    Electronic Resource
    Electronic Resource
    Fetal globoid cell leukodystrophy in one of twins (1979)
    Springer
    Acta neuropathologica 47 (1979), S. 151-154 
    Details
    ISSN: 1432-0533
    Keywords: Fetal globoid cell leukodystrophy ; Globoid cells ; Galactocerebrosidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twins with high-risk globoid cell leukodystrophy (GLD) at the 6th gestational month were studied morphologically and enzymatically. One of them was affected and the other was probably the carrier of this disease. Central nervous system and other viscera developed normally for the gestational age in both fetuses. The lesions of GLD were found in the fetus with marked deficiency of galactocerebrosidase, but not in the probable carrier. The lesions were located only in the considerably myelinated areas viz., the brain stem and the spinal cord. Ultrastructurally, the globoid cells in the fetal GLD seemed to originate from glial cells, probably oligodendroglia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00717039
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  • 8
    Electronic Resource
    Electronic Resource
    Prognosis of Wilson's disease in childhood (1977)
    Springer
    European journal of pediatrics 126 (1977), S. 147-154 
    Details
    ISSN: 1432-1076
    Keywords: Wilson's disease ; D-penicillamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Wilson's disease in childhood has several characters distinct from those in adults. The progression of the disease tends to be rapid, hepatic manifestations are common, cerebral symptoms related to dystonia are predominant, and tremor is rare. Forty-nine children with Wilson's disease under the age of 15 were treated with D-penicillamine for 2 to 15 years. None of the presymptomatic patients subsequently developed any symptoms of the disease. The results of treatment in patients who had exhibited only hepatic symptoms were also excellent. However, neurological manifestations associated with a history of jaundice or ascites responded less well to chelation. These observations clearly indicate that early diagnosis and treatment are extremely important to ensure normal lives for children with Wilson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442196
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  • 9
    Electronic Resource
    Electronic Resource
    Structural studies of O-cyclocytidine derivatives. III. The crystal and molecular structure of 2,2'-anhydro-1-β-D-arabinofuranosylcytosine-3',5'-diphosphate monohydrate (1979)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 35 (1979), S. 1136-1140 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740879005732
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  • 10
    Electronic Resource
    Electronic Resource
    The effect of oxidation state on the intensities of Kβ5 and Kβ″ of 3d-transition elements (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 4 (1975), S. 186-189 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Using a commercially available flat crystal spectrometer in a slightly modified form, an investigation was made of the peak intensity ratios (Kβ5/Kβ1) and the relative intensities of Kβ″ to Kβ5 in different oxidation states of 3d-transition metal atoms existing in forms of oxidic compounds. The peak intensity ratios (Kβ5/Kβ1) for V, Cr, Mn, Fe, Co, Ni and Cu, as well as the peak profiles of Kβ″ and Kβ5 for V, Cr and Mn, were investigated. Results suggest that changes in the intensities of the Kβ5 and Kβ″ bands can be applied to determining the oxidation number of a metal atom in its oxide.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300040408
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