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Inhibition of isolation-induced aggressive behavior with GABA transaminase inhibitors (1979)

DaVanzo, John P. ; Sydow, M.

Springer

Psychopharmacology 62 (1979), S. 23-27

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ISSN: 1432-2072

Keywords: Isolation-induced aggressive behavior ; GABA ; Aminooxyacetic acid ; γ-Acetylenic GABA

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Administration of aminooxyacetic acid (AOAA) and γ-acetylenic GABA (GAG) resulted in a dose-dependent suppression of aggressive behavior and a concomitant increase in brain GABA. The increase in GABA levels persisted beyond the time when AOAA and GAG exerted an anti-aggressive effect. Brain GABA levels remained significantly elevated over controls for 120 h after a single injection of AOAA and 46 h after a single dose of GAG.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00426030

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