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  • 1975-1979  (11)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Random-coil dimensions of poly(trimethylene oxide), an unusually compact chain molecule (1976)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 98 (1976), S. 3756-3760 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00429a003
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  • 2
    Electronic Resource
    Electronic Resource
    Differences in transcription of unique DNA sequences between neuronal and glial cells (1975)
    [s.l.] : Nature Publishing Group
    Nature 256 (1975), S. 233-234 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fifty minutes after injection of 5,6-3H-uridine (specific activity 43 (Dimmer1, Radiochemical Centre, Amersham) into the subarachroidal space of a 15-18-d-old rat, the animal was decapitated. Then the brain was removed and homogenised in a solution containing 2.2 M sucrose and 1.5mM CaCl2, and the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/256233a0
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  • 3
    Electronic Resource
    Electronic Resource
    IN VITRO BIOSYNTHESIS OF TUBULIN ON TOTAL, FREE AND MEMBRANE-BOUND POLYSOMES FROM THE DEVELOPING RAT BRAIN (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 31 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Incorporation of [3H]leucine into tubulin and total protein was examined using a polysomal system from newborn (1-day-old). young (10-day-old) and adult (3-month-old) rat brains and cerebral cortices. The rate of tubulin biosynthesis (specific radioactivity) was always lower than that of total protein biosynthesis. No significant differences in the specific radioactivities of the synthesized total proteins were found between the newborn and young brain polysomal system, although young cerebral cortical polysomes were less active than newborn cerebral cortical polysomes. The adult brain (or cerebral cortical) polysomes were less active, about 20-30% lower than the young brain (or cerebral cortical) polysomes. The incorporation of [3H]leucine into tubulin showed a progressive decrease in the polysomal systems isolated from the newborn, young and adult rat brains and cerebral cortices. These tendencies were similar in every cell sap taken from newborn, young and adult rat brain homogenates.In order to examine the relative activities of free and bound polysomes of the developing rat brain in tubulin biosynthesis. double-labelling experiments were carried out. Labelled tubulin was purified by the assembly and disassembly method, followed by SDS gel electrophoresis, or by vinblastine precipitation method, followed by SDS gel electrophoresis; then identification by co-electrophoresis with native brain tubulin, molecular weight determination and demonstration of specific aggregation in the presence of GTP followed. Free and bound polysomes showed approximately similar activities during tubulin biosynthesis. Furthermore, relative activities of tubulin biosynthesis by free and bound polysomes did not significantly change during development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb06561.x
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  • 4
    Electronic Resource
    Electronic Resource
    A SIMPLE METHOD FOR THE PREPARATION OF THE IMMUNOGLOBULINS TO HYDROXYINDOLE O-METHYLTRANSFERASE (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 31 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A simple procedure is described for the preparation of the monospecific immunoglobulins (Ig) to bovine pineal hydroxyindole O-methyltransferase (HIOMT) (EC 2.1.1.4). We observed that anti-serum to HIOMT was produced in rabbits which had received subcutaneous inoculations of the crude pineal extract. The monospecific Ig to HIOMT were isolated by an immunoadsorption technique in which the brain extract was coupled to the CNBr-activated Sepharose. The purified Ig gave a single precipitin line against the pineal extract on an Ouchterlony double diffusion plate and also by immunoelectrophoresis. All other extracts tested, cerebral cortex, cerebellum, thalamus, caudate nuclei, superior coliculus, liver, adrenal gland, kidney, retina and serum did not express precipitin lines to the purified Ig. When immunochemical titration was used, the pineal HIOMT was quantitatively precipitated by the monospecific Ig.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb00115.x
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  • 5
    Electronic Resource
    Electronic Resource
    PURIFICATION OF BOVINE PINEAL HYDROXYINDOLE O-methylTRANSFERASE BY IMMUNOADSORPTION CHROMATOGRAPHY (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 31 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A procedure is described for the use of immunoadsorption chromatography of hydroxyindole O-methyltransferase (HIOMT). HIOMT was purified from bovine pineal extract by affinity chromatography on immunoglobulins (Ig)-Sepharose. The overall purification was about 45-fold; the yield was 84%. This enzyme constitutes about 2.0% of the soluble proteins in the pineal gland. The enzyme represented a single precipitin line on Ouchterlony double diffusion plate and immunoelectrophoresis. Ultracentrifugation analysis indicated the existence of molecular aggregates of enzyme and disc gel electrophoresis showed one main protein band and several minor bands. However sodium dodecyl sulphate (SDS) gel electrophoresis showed a single protein band with subunit molecular weight 38,000 demonstrating bovine pineal HIOMT to be polymer enzyme of a single subunit. The properties of the purified enzyme including disc gel electrophoretic pattern, the effect of pH, chemicals and substrates and immunological properties were identical with those of the crude enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb00116.x
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  • 6
    Electronic Resource
    Electronic Resource
    ISOLATION AND CHARACTERIZATION OF DNA-DEPENDENT RNA POLYMERASE A, B AND C FROM RAT BRAIN NUCLEI (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 31 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— DNA-dependent RNA polymerase activities were solubilized from the brain nuclei of young rats. Six forms of RNA polymerases were distinguished on DEAE-Sephadex A-25 chromatography and designated A, BI, BII, CI, CII, and Oil by their sensitivities to α-amanitin. CII enzyme was shown to derive from CIII enzyme by serine-protease digestion. CI enzyme was also suggested to be a product of a proteolytic process.Using a DNA template, enzyme A was completely resistant to α-amanitin; BI and BII enzymes were equally sensitive to this toxin (50% inhibition at 0.006 μg/ml); while C enzymes showed intermediate sensitivity (50% inhibition at 30 μg/ml). When poly[d(A-T)] was used as a template, α-amanitin sensitivities were altered in A, CI, CII, and CIII enzymes without any change in the BII enzyme. CI, CII and CIII enzymes were greatly stimulated by poly[d(A-T)], whereas A and BII enzymes were only slightly stimulated. All six forms of RNA polymerases were extensively characterized with respect to their ammonium sulphate optima, effects of divalent metal ions, template requirements and pH optima, using DNA and poly[d(A-T)] as templates. The results show new findings in several properties and supply basic data for discussion and future studies on RNA metabolism of the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb02660.x
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  • 7
    Electronic Resource
    Electronic Resource
    TRANSCRIPTION OF REPEATED AND UNIQUE DNA SEQUENCES IN BRAIN NUCLEI (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 26 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —Transcription of repeated and unique DNA in rat brain nuclei was examined using a RNA-DNA hybridization technique. Saturation hybridization experiments with a membrane filter showed that there were differences in the base sequence complements between labelled brain and labelled liver nuclear RNA. In competition hybridization experiments using a membrane filter, brain nuclear labelled RNA was in competition most effectively with unlabelled brain nuclear RNA, but less effectively with kidney or liver nuclear RNA. Experiments using a membrane filter loaded with isolated unique or repeated DNA fragments gave similar results. Furthermore, competition hybridization with a DNA excess also showed similar results at Cot 10,000. These results indicate the existence of tissue-specificity in the transcription of unique and repeated DNA sequences in brain nuclei. Subsequently, rat brain nuclei were separated into neuronal and glial nuclear fractions for the purpose of detecting the cell-specificity of RNA. The results of these experiments give evidence of significant differences in the transcription of unique DNA sequences, but indicate no differences in that of repeated DNA sequences between the two nuclear classes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb04440.x
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  • 8
    Electronic Resource
    Electronic Resource
    Day-to-day and seasonal fluctuations of urban mortality in Kyoto, Japan (1979)
    Springer
    International journal of biometeorology 23 (1979), S. 89-105 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract The study and interpretation of temporal variability in mortality requires the consideration of both exogenous and endogenous influences as underlying factors. In the present paper the relative contribution of fluctuations in daily weather was investigated using the unbiased techniques of lagged cross-correlation and spectral analyses. The study focused on patterns of daily mortality in Kyoto, Japan. Studied herein were total mortality of all ages less accidental, ischemic heart (IHD), cerebrovascular (CVD), cardiovascular (IHD + CVD), cancer and among elderly (over 70 years of age) deaths. The meteorological factors were mean, maximum and minimum daily temperature, mean barometric pressure, mean relative humidity, and mean and maximum wind speed. It was found that after extreme weather conditions, such as heat waves (with mean air temperature in excess of 30°C) or the intrusion of cold waves (with mean air temperature below 0°C), mortality increased to about three times the daily average with a lag effect of usually one—three days and up to one week. Over the year, however, weather fluctuations were found to account statistically for no more than 10% of the overall annual variability in mortality. Importantly, the short-term upswings in mortality were usually accompanied by noticeable drops in the number of deaths on the subsequent days suggesting a triggering effect of external factors. The most weather-sensitive mortality group was people over 70 years of age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01560089
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  • 9
    Electronic Resource
    Electronic Resource
    Mixed-system brain dynamics: Neural memory as a macroscopic ordered state (1979)
    Springer
    Foundations of physics 9 (1979), S. 301-327 
    Details
    ISSN: 1572-9516
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The paper reviews the current situation regarding a new theory of brain dynamics put forward by the authors in an earlier publication. Motivation for the theory is discussed in terms of two issues: the long-standing problem of accounting for the stability and nonlocal properties of memory, and the experimental and theoretical evidence against the classical theory of brain action. It is shown that the new theory provides an explanation and a conceptually unifying framework for phenomena of brain action that resist classical explanation. Further independent experiments provide strong additional support for the theory. The fact that this theory incorporates quantum mechanisms in an essential way is considered to be of wide scientific interest in view of the unique status of the brain in relation to the physical, biological, and mental orders in nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00715185
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  • 10
    Electronic Resource
    Electronic Resource
    Potential temperature standards for torsional braid analysis (1975)
    Springer
    Journal of thermal analysis and calorimetry 8 (1975), S. 125-134 
    Details
    ISSN: 1572-8943
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Résumé Du fait que la soudure du thermocouple de mesure de la température n'est pas en contact avec l'échantillon, il est nécessaire dans cette technique d'utiliser des étalons de température. La technique par analyse avec fil de torsion (torsional braid analysis, TBA) a été développée spécialement pour être appliquée aux hauts polymères mais ceux-ci ne peuvent pas servir pour l'étalonnage. Ayant observé que les températures de transition et de fusion de plusieurs substances de faibles poids moléculaires, comme l'eau, l'o-terphényle, le nitrate de potassium et lep-azoxyanisol étaient décelées par TBA, on discute la possibilité de les utiliser pour l'étalonnage. Les résultats montrent que l'eau, l'o-terphényle et le nitrate de potassium se prêtent à cette utilisation.
    Abstract: Zusammenfassung Die Torsionsfaden-Analyse (torsional braid analysis, TBA) wurde zum Einsatz bei Hochpolymeren entwickelt, welche sich als Standard-Substanzen nicht bewähren. Da der Anschluß der Thermoelemente nicht in Berührung mit der Probe kommt, werden deshalb zur Analyse spezielle Temperature-Eichsubstanzen benötigt. Übergangs- und Schmelztemperaturen verschiedener Substanzen niedrigen Molekulargewichts, wie Wasser,o-Terphenyl, Kaliumnitrat undp-Azoxyanisol wurden mittels TBA erfaßt und ihre Eignung als Standardsubstanz für diese Methode erörtert. Aufgrund der Ergebnisse können Wasser,o-Terphenyl und Kaliumnitrat als Standardsubstanzen eingesetzt werden.
    Notes: Abstract In torsional braid analysis (TBA) the thermocouple junction is not in contact with the specimen, and therefore temperature standards are necessary. However TBA is devised only for application to high polymers, which are not appropriate for standards. The transition and fusion temperatures of several substances of low molecular weight, such as water,o-terphenyl, potassium nitrate andn-azoxyanisole, have been studied by TBA, and their applicability as standards to TBA is discussed. It is found that water,o-terphenyl and potassium nitrate can be used as standards.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01912469
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