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Digitale Medien

A code controlling specific binding of regulatory proteins to DNA (1976)

Gursky, A. V. ; Tumanyan, V. G. ; Zasedatelev, A. S. ; [weitere]

Springer

Molecular biology reports 2 (1976), S. 413-425

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ISSN: 1573-4978

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract A possible code is suggested that describes a correspondence between amino acid sequences in stereospecific sites of regulatory proteins and nucleotide sequences at the control sites on DNA. Stereospecific sites of regulatory proteins are assumed to contain pairs of antiparallel polypeptide chain segments which form a right-hand twisted antiparallel β-sheet with single-stranded regions at the ends of the β-structure. The binding reaction between regulatory protein and double-helical DNA is accompanied by significant structural alterations at stereospecific sites of the protein and DNA. Half of the hydrogen bonds normally existing in β-structure are broken upon complex formation with DNA and a new set of hydrogen bonds is formed between polypeptide amide groups and DNA base pairs. The code states a correspondence between four amino acid residues at a stereospecific site of the regulatory protein and an AT (GC) base pair at the control site. It predicts that there are six fundamental amino acid residues (serine, threonine, histidine, asparagine, glutamine and cysteine) whose arrangement in the stereospecific site determines the base pair sequence to which a given regulatory protein would bind preferentially.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00366264

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Digitale Medien

A model for the binding of lac repressor to the lac operator (1976)

Gursky, G. V. ; Tumanyan, V. G. ; Zasedatelev, A. S. ; [weitere]

Springer

Molecular biology reports 2 (1976), S. 427-434

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ISSN: 1573-4978

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract A model is suggested for the lac repressor binding to the lac operator in which the repressor polypeptide chain sequences from Gly 14 to Ala 32 and from Ala 53 to Leu 71 are involved in specific interaction with operator DNA. A correspondence between the protein and DNA sequences is found which explains specificity of the repressor binding to the lac operator. The model can be extended to describe specific binding of other regulatory proteins to DNA.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00366265

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Digitale Medien

Investigation of fibrous structures. II. General method for the elucidation of the conformations of the complementary nucleic acids (1975)

Tumanyan, V. G. ; Esipova, Natalia G.

New York : Wiley-Blackwell

Biopolymers 14 (1975), S. 2231-2246

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ISSN: 0006-3525

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The problem of deducing the DNA structure with correct base pairing and specific symmetry is formulated in the form of algebraic equations. In this way the number of independent variables determining double-helix conformation can be reduced from six to four. The effectiveness of the method is illustrated by the computations for A-DNA and B-DNA. The method allows one to predict all possible conformations of the complementary nucleic acids.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bip.1975.360141102

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