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Pharmacokinetics of nomifensine in man (1975)

Vereczkey, L. ; Bianchetti, G. ; Garattini, S. ; [et al.]

Springer

Psychopharmacology 45 (1975), S. 225-227

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ISSN: 1432-2072

Keywords: Plasma levels ; Nomifensine ; Kinetics ; Volunteers

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Nomifensine pharmacokinetics were determined in healthy volunteers after the oral administration of 50 mg of the drug. Peak plasma levels of 95-177 ng/ml were attained within 1 to 4 hrs, and the apparent plasma half-lives ranged from 3.3 to 4.9 hrs. Assuming 100% bioavailability the drug has a relatively large apparent volume of distribution. From these findings it appears that the pharmacokinetics profile of nomifensine is considerably different from those of other known antidepressants. Implications for dosages schedules are discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00429065

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