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  • 2005-2009  (2)
  • 1970-1974  (4)
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  • 1
    Electronic Resource
    Electronic Resource
    Dapsone suppresses human neutrophil superoxide production and elastase release in a calcium-dependent manner (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 152 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Dapsone (4,4′-diaminodiphenyl sulphone) is a powerful therapeutic tool in many skin diseases including neutrophilic dermatoses. The drug has an outstanding therapeutic efficacy against many skin diseases characterized by neutrophil-rich infiltrates; however, mechanisms of its action are poorly understood.Objectives  We investigated the effects of dapsone on respiratory and secretory functions of human neutrophils triggered by the chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), the physiological agonist C5a, and phorbol myristate acetate (PMA).Methods  Human neutrophils were isolated from venous blood obtained from healthy donors. We detected extracellular production of superoxide (O2–) by cytochrome C reduction assay, and intracellular production of O2– by flow cytometry. Neutrophil elastase release was measured by the cleavage of the specific elastase substrate N-methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide. Measurement of cytosolic free calcium concentration was performed using the calcium-reactive fluorescence probe, Fluo-3.Results  Dapsone suppressed intra- and extracellular production of O2– and elastase release triggered by fMLP and C5a, but not by PMA. Both fMLP and C5a signalled the above pathways by inducing calcium influx, but PMA functions bypassed calcium influx. Dapsone was capable of antagonizing the induction of calcium influx.Conclusions  These findings suggest that one mechanism of the anti-inflammatory action of dapsone is inhibition of calcium-dependent functions of neutrophils including release of tissue-damaging oxidants and proteases in the affected skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06559.x
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  • 2
    Electronic Resource
    Electronic Resource
    Seizing mechanism and fate of intranuclear mitochondria (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1347-1348 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung In Kernen transplantierter Tumorzellen, die aus adrenocortikalem Carcinom des syrischen Goldhamsters stammen, wurden häufig Mitochondrien und kleine Bläschen festgestellt. Diese Strukturen wurden in Anatelophase von Kernen umgeben und innerhalb eines Zellenzyklus werden die eingekreisten Mitochondrien allmählich im Kern aufgelöst.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965337
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Induction of neurosarcoma by injections of N-nitrosobutylurea in suckling syrian golden hamsters (1971)
    Springer
    Cellular and molecular life sciences 27 (1971), S. 1459-1460 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Durch Injektion von N-Nitrosobutylharnstoff in junge Goldhamster wurden in über 50% der Versuchstiere Neurosarkome erzeugt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02154289
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  • 4
    Electronic Resource
    Electronic Resource
    Ultra-Precision Finishing of Micro Aspherical Surface by Ultrasonic Vibration Assisted Polishing (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 291-292 (Aug. 2005), p. 349-354 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Micro axis-symmetric aspherical glass lenses are being increasingly used in digital devices and optical devices. The glass lenses are molded by using micro ceramic dies such as tungsten carbide [1].Recently, as the pixel number of digital image sensors increases, the accuracy of micro molding dies are required to be much more precise than ever [2]. In this study, ultrasonic assisted polishing method is proposed and developed in order to finish micro axis-symmetric aspherical dies which were pre-ground with a diamond wheel [3]. In this paper, the proposed polishing method was applied to the micro aspherical molding dies to finish form compensation processing
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.291-292.349.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    Polarographic determination of critical micelle concentration of anionic surfactants (1971)
    Springer
    Colloid & polymer science 248 (1971), S. 959-962 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Zusammenfassung Es wurden die kritischen Mizellbildungskonzentrationen (KMK) von anionischen Tensiden durch Gleichstrompolarographie in Abwesenheit von Leitelektrolyten bestimmt.
    Notes: Summary Critical micelle concentrations of four anionic surfactants were determined by DC polarographic desorption waves of the surfactants without supporting electrolyte. The linear plot obtained between the potentials of the desorption waves and the logarithmic concentrations of the surfactant had an inflection point which corresponded to the CMC. The CMC values obtained are in good agreement with those in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01508055
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  • 6
    Electronic Resource
    Electronic Resource
    Preparation of immobilized enzymes by N-Vinylpyrrolidone and the general properties of the glucoamylase gel (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 16 (1974), S. 1517-1528 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Immobilized glucoamylase, invertase, and β-galactosidase were prepared by using N-vinylpyrrolidone monomer (VP) under γ-ray irradiation. The enzyme-VP solutions were gelled by irradiation with 2.9 Mrad and the added enzymes were almost completely entrapped. Activity losses on entrapping were 55% for the VP-glucoamylase gel, and more than 90% in the case of VP-invertase and VP-β-galactosidase gels. No leakage of enzyme from these gels could be detected within 1 hr. The VP-glucoamylase gel was capable of hydrolyzing dextrin (mol wt 10,400) to glucose and the glucose equivalent was equal to that obtain able with native enzyme. The optimum temperature, heat stability, pH activity curve, and pH stability of VP-glucoamylase gel were slightly inferior to those of native enzyme, while Km was a little larger than that of native enzyme.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260161108
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