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  • 1995-1999  (7)
  • 1970-1974  (5)
  • 1965-1969  (1)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 93 (1971), S. 6448-6454 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 8 (1972), S. 10-18 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: We have synthesized a series of non-macrocyclic ligands to FKBP12 that are comparable in binding potency and peptidyl prolyl isomerase (PPIase) inhibition to FK506 itself. We have also solved the structure of one of these ligands in complex with FKBP12, and have compared that structure to the FK506–FKBP12 complex. Consistent with the observed inhibitory equipotency of these compounds, we observe a strong similarity in the conformation of the two ligands in the region of the protein that mediates PPIase activity. Our compounds, however, are not immunosuppressive. In the FKBP12–FK506 complex, a significant portion of the FK506 ligand, its `effector domain', projects beyond the envelope of the binding protein in a manner that is suggestive of a potential interaction with a second protein, the calcium-dependent phosphatase, calcineurin, whose inhibition by the FKBP 12–FK506 complex interrupts the T-cell activation events leading to immunosuppression. In contrast, our compounds bind within the surface envelope of FKBP12, and induce significant changes in the structure of the FKBP12 protein which may also affect calcineurin binding indirectly.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 9189-9193 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 76 (1972), S. 1035-1040 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1436-5073
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die Flüssigkeits-Szintillationszählung zur Bestimmung von14C-markiertem Ametryn in Dünnschichtchromatogrammen wurde eingehend geprüft. Alterung, Löschungseffekt von Trägersubstanz und Adsorptionsmitteln, Temperaturbeständigkeit der Verbindung in adsorbiertem Zustand wurden untersucht. Die Reproduzierbarkeit beträgt 1 bis 2%, die Nachweisgrenze 0,005μg pro Tüpfel, das Signal-Hintergrund-Verhältnis 3∶1. Zur Lokalisierung der Flecken wurde die Fluoreszenzlöschung herangezogen. Die Ausbeute nach 30 Minuten Entwicklung auf Silikagelplatten war ungefähr 90% Ametryn, unabhängig vom Laufmittel. Bei zweidimensionaler Arbeitsweise wurden 75% wiedergefunden. Die Ausbeute aus Wasser- und Bodenproben lag zwischen 78 und 88%.
    Notes: Summary The use of the liquid scintillation counting method for the determination of14C labelled ametryne on thin-layer chromatograms has been thoroughly investigated. Aging, quenching effect of carrier and adsorbents as well as temperature stability of the compound in the adsorbed state have been studied. The method has a reproducibility of 1 to 2% and a detection limit of 0.005μg per spot at a 3 ∶ 1 signal to background ratio. Fluorescence quenching was used for the location of spots on the chromatogram. Recovery studies were carried out by this method. After 30 minutes development on a chromatoplate coated with silicagel, about 90% of the ametryne was recovered independent of solvent system used. About 75% of the ametryne was recovered from a two-dimensional chromatogram. Recoveries of ametryne from water and soil samples ranged between 78 and 88%.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 1 (1971), S. 53-63 
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Molten bisulphates form an interesting class of low-temperature fused salts which quench to form glasses; some technical and theoretical applications of these systems are discussed. The NaHSO4KHSO-4 eutectic (46.5% KHSO4, m.p. 125°C,T g 25°C) is easy to study since at lower temperatures decomposition of the melt is retarded and supercooling readily occurs. The solvent properties of this eutectic towards both inorganic and organic solutes have been investigated. The oxidation states available to transition and post-transition metals were studied spectrophotometrically and voltametrically; the results show a very restricted pattern of redox chemistry. The (abbreviated) electrochemical series is V(V)/V(IV)〉Mn(III)/Mn(II)〉H(I)/H2(O)〉Ag(I)/Ag(O)〉Mo(VI)/Mo(V)〉 Hg(I)/Hg(O)〉Cu(II)/Cu(O)〉Zn(II)/Zn(O). The Hammett acidity function,H 0, was measured as in the range −1 to −2. Various factors influencing redox reactions in the melt are discussed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 42 (1997), S. 404-407 
    ISSN: 1573-2568
    Keywords: IRRITABLE BOWEL SYNDROME ; UROLOGICAL SYMPTOMS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Irritable bowel syndrome patients often complainof urinary symptoms such as frequency, urgency, anddysuria, raising the possibility of inappropriatereferral to the urologist. To resolve this issue, the prevalence of irritable bowel syndrome wascompared in patients attending urological and controlclinics (dermatology and ENT). The overall prevalence ofirritable bowel syndrome was 31.2% in the urological clinic compared with 21.2% in the controls (P〈 0.001), but striking differences emerged, dependingon presenting complaint. Irritable bowel symptoms wereparticularly common in patients presenting with loin pain (male: 40.9%, P = 0.004; female: 50%, P =0.03), dysuria (male: 43.8%, P = 0.007; female: 46.2%,P = 0.01) and frequency/urgency (male: 31.7%, P = 0.002;female: 42.4%, P = 0.006), and the male/femaleprevalence was 24% and 44%. These results suggest that inirritable bowel syndrome, urinary symptoms includingloin pain can present diagnostic dilemmas in both thegastroenterological and urological setting, underlining the importance of specialists in these fieldsworking together in order to define better ways ofmanaging such patients.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 210 (1996), S. 255-271 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract In this paper we present a brief review of the current state of positron annihilation research into the phase behaviour of fluids confined within restricted boundaries. We summarise, in the form of selected examples, the work done so far on: (1) fluids confined in the nanometer-size pores of VYCOR glass, with particular emphasis on the confined phase diagram and the mechanisms behind phase transitions compared to bulk. (2) The adsorption/physisorption of gases on internal surfaces of grafoil and the potential of positron technique for revealing physical properties, such as the intricate molecular arrangements during phase transitions of the “layered” fluid.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of radioanalytical and nuclear chemistry 211 (1996), S. 173-179 
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The phase behaviour of carbon dioxide confined in VYCOR glass at pressures below that of the bulk triple point (∼0.51 MPa) has been investigated. The temperature at which freezing occurs appears to be pressure dependent below 0.3 MPa. As experiments are performed at successively lower pressures, the confined phase transitions gradually disappear, due to either partial pore filling, or the proximity of the confined triple point.
    Type of Medium: Electronic Resource
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