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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 117 (1995), S. 3565-3592 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 25 (1995), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The economic impact and medical complication rate of the common cold are well documented, but many of the physiological, inflammatory, and immune responses to common cold viruses have only recently been investigated. The purpose of this study was to compare selected systemic immune and inflammatory responses to experimental rhinovirus (RV)-39 challenge in seronegative allergic rhinitis and non-allergic rhinitis subjects. Peripheral blood was obtained before (baseline), during (acute), and 23 days after (convalescent) RV-39 intranasal challenge and assayed for leucocyte histamine release, serum immunoglobulins, allergen-specific IgE antibodies, plasma histamine. and platelet aggregation. All subjects were infected, as manifested by viral shedding in nasal secretions or seroconversion. RV-39 infection induced significant acute increases in serum IgE. leucocyte histamine release, and platelet aggregation, but caused no changes in serum IgG, serum IgA, serum IgM, and plasma histamine. The first change was confined to the allergic rhinitis subjects. There was no evidence that the acute rise in total serum IgE was due to an elevation of a pre-existing, pollen-specific serum IgE antibody. The results show that intranasal challenge with RV-39 induced changes in systemic immune and inflammatory parameters with a unique response pattern in allergic rhinitis subjects.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Der Schmerz 10 (1996), S. 216-217 
    ISSN: 1432-2129
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 21 (1997), S. 77-82 
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Nous avons examiné le déplacement antéropostérieur de la tête humérale dans l’articulation glénohumérale en utilisant l’Imagerie par Résonance Magnétique (IRM). Nous avons étudiés 10 épaules normales, 11 épaules avec une instabilité antéropostérieure, 10 épaules stabilisées par la procédure de Putti-Platt et une épaule avec une instabilité multidirectionnelle. Nous avons mis le bras en 3 positions différentes: en rotation interne, en rotation externe et en abduction complète. Nous avons utilisé l’imagerie par echo de gradient. 22 épaules se prêtaient bien à l’évaluation. Nous avons obtenu des résultats constants dans les épaules normales. Les épaules instables et stabilisées montraient une plus grande variance. En rotation externe, nous n’avons pas trouvé un déplacement significatif dans aucune groupe. Cependant, la rotation externe était significativement réduite dans les épaules instables et les épaules stabilisées (P 〈0.01). Nous avons trouvé une tendance à un déplacement postérieure quand le bras était mis en rotation interne, avec une moyenne de 1 (±ku0.44) mm dans les épaules normales, 0.89 (±ku1.67) mm dans les épaules instables et 1.6 (±ku1.4) mm dans les épaules stabilisées.
    Notes: Summary. Anteroposterior translation of the humeral head within the glenohumeral joint was investigated using MRI. Ten normal shoulders, 11 recurrent anterior dislocations, 10 stabilised shoulders after the Putti-Platt operation and one shoulder with multidirectional instability, were scanned. The arm was positioned in internal and external rotation and in an overhead position. Gradient echo volume acquisition scans were carried out, and 22 were suitable for evaluation. Consistent results were obtained in the normal shoulders. The unstable and unstable shoulders showed higher variance, but there was no significant anterior translation in external rotation in any group. The range of external rotation was significantly reduced in the unstable and stabilised shoulders. A trend towards posterior translation was found in internal rotation with a mean of 1 (±ku 0.44) in normal, 0.89 (±ku1.67) in unstable and 1.6 (±ku1.4) in stabilised shoulders.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 30 (1974), S. 1613-1615 
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 28 (1971), S. 38-54 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Der Stoffwechsel der Gamma-amino-Buttersäure (GABS) wurde mit Hilfe einer klassischen chromogenen histochemischen Methode (Nachweis von GABS-Transaminase→Succin-semialdehyd-Dehydrogenase) sowie mit licht- und elektronenmikroskopischer Autoradiographie des Enzymhemmstoffes 14C-Thiosemicarbazid im Hippocampus der Ratte untersucht. Die histochemische wie auch die autoradiographische Methode beweisen eine gliozelluläre Lokalisation des GABS-Stoffwechsels, der sich hauptsächlich an glioneuronalen Zwischenmembranen konzentriert. Sich widersprechende Angaben der einschlägigen biochemischen Literatur können anhand unserer Ergebnisse interpretiert werden. Die glio-zelluläre Lokalisation des limbischen GABS-Stoffwechsels eröffnet neue Perspektiven für die neurophysiologische Interpretierung und pharmakotherapeutische Beeinflussung der Anomalien der Verhaltens-Reflexmechanismen.
    Notes: Summary GABA-metabolism in the rat hippocampal formation has been studied by means of classical chromogenic histochemistry (localisation of the GABA-transaminase→succinic semialdehyde dehydrogenase system) and by means of light- and electron microscopic autoradiographic localization of the enzyme-inhibitor 14C-thiosemicarbazide. Both the histochemical and the autoradiographic approaches proved a gliocellular localization of GABA metabolism, concentrated at glio-neuronal interfaces. Contradictory data of relevant biochemical literature can readily be explained on the basis of these results, offering new perspectives for neurophysiological interpretation and pharmacotherapeutical treatment of behavioral limbic disorders.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 29 (1973), S. 357-358 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Es wird gezeigt, dass an erwachsenen und neugeborenen Ratten die Jodaufnahme des Thymus bei den letzteren viel höher ist als die Jodaufnahme der Thyroidea. Dies unterstützt die These, wonach die Jodspeicherkapazität der Thyroidea das Resultat einer Differenzierung darstellt, indem auf früherer ontogenetischer Stufe für den ganzen Vorderdarm eine Jodspeicherkapazität besteht.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-5044
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cryopreservation of somatic embryos of Aesculus hippocastanum L. cultured on nutritive media containing abscisic acid (ABA) at concentrations of 0.75 μM, 7.5 μM and 75.0 μM was evaluated for three cooling methods: (i) slow freezing with cryoprotectants, (ii) fast freezing with cryoprotectants, and (iii) fast freezing with desiccation techniques. The ‘cryoprotectant’ freezing techniques included the embryo pretreatment on ABA containing medium for 4 days, followed by cryoprotective treatment in liquid medium containing 0.5 M dimethylsulfoxide, 0.5 M glycerol, 1.0 M sucrose, and cooled at slow, and rapid rates. Embryos pretreated on a medium containing 0.75 μM ABA, and cooled to −35 °C at 1°C /min, held for 30 min at this transfer temperature and then immersed in liquid nitrogen (LN) had the best embryo recovery (43%). The ‘desiccation’ method involved an air drying step of similar ABA-pretreated, non-cryoprotected embryos followed by rapid cooling. Embryos precultured on 0.75 μM ABA, then subjected to a 4 h period of air desiccation (water content reduction to 13%) showed about the same level of survival (46%) as found with the ‘cryoprotectant’ slow freezing technique. The air-dry ‘desiccation’ method is easier to apply than the more complicated ‘cryoprotectant’ method.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. S6 
    ISSN: 1434-4726
    Keywords: Cochlea ; Field stimulation ; Vascular endothelium ; Vasorelaxation ; Glibenclamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rabbit aortic rings relaxed with an increase in cyclic guanosine monophosphate and cyclic adenosine monophosphate content in response to exposure to organ fluid of isolated cochleas of the guinea pig following field stimulation (50 Hz, 80 V, 0.2 ms). Relaxations were blocked by 30 μMN G-nitro-l-arginine methyl ester added to the vessel rings. This inhibitory effect was reversed by 3 MMl-arginine. Removal of the vascular endothelium also blocked the relaxation response. Glibenclamide attenuated vasorelaxation in a concentration-dependent manner. We conclude that cochlear nerve stimulation induces an endothelium-dependent vasorelaxation involving activation of adenosine triphosphate-sensitive potassium channels.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 153 (1974), S. 559-564 
    ISSN: 1432-0878
    Keywords: Hypothalamus ; Afferents ; Adrenal gland ; Protein synthesis ; Auto-radiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of unilateral adrenalectomy on the incorporation of tritiated leucine into the ventromedial nucleus of both sides of the rat hypothalamus was studied by light- and electron-microscopical autoradiography. The left adrenal had been removed and 14 days later labeled amino acid was given intravenously. Rats were killed 5, 30, 60 and 120 min after isotope administration. Following unilateral adrenalectomy there is a marked difference in the autoradiographic reaction of both sides of the hypothalamic ventromedial nucleus. On the right side the number of autoradiographic silver grains is much higher than on the left side, the difference being statistically significant for each animal and for each time interval. In accordance with previous findings the data suggest the existence of a neural pathway from the adrenal gland to the hypothalamus.
    Type of Medium: Electronic Resource
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