ISSN:
1042-7163
Schlagwort(e):
Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
The highly efficient syntheses of novel protected glyphosate imidate, thioimidate, and thiono ester derivatives are described starting from N-[diphenoxyphosphinylmethyl]glycinonitrile 3b. The scope, utility and limitations in using each of these activated carboxylate functionalities for further transformations to new “masked” heterocyclic derivatives are defined. While the solution stability of the imidate and thioimidate series limited the synthetic application of these species, the corresponding thiono ester derivatives were valuable synthetic intermediates, providing a short, efficient route to the first glyphosate derivatives containing 1,3,4-oxadiazole and 1,2,4-triazole ring systems in place of the carboxylate group. These thiono esters thus undergo selective nucleophilic addition at this activated carboxylate center, while retaining the reactive diphenyl phosphonate moiety.
Zusätzliches Material:
4 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/hc.520030314
Permalink