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  • 1
    Electronic Resource
    Electronic Resource
    PURIFICATION AND CHARACTERISTICS OF RNase INHIBITOR FROM PIG CEREBRAL CORTEX (1970)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 17 (1970), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— An RNase inhibitor has been purified from pig cerebral cortex by DEAE-cellulose and hydroxylapatite chromatography and Sephadex G-100 gel filtration. The purified RNase inhibitor could be resolved into a major band (about 80–85 per cent of total protein) and several minor components by polyacrylamide gel electrophoresis.The ultraviolet absorption curve of the purified RNase inhibitor indicated a typical protein spectrum. The inhibitor was inactivated by digestion with trypsin or prozyme, and by heating at 70ºC for 5 min. The inhibitor was also inactivated by an SH reagent such as p-chloromercuribenzoate. The inhibitor did not affect RNase T1. It has been suggested that the inhibitor is an acidic protein and also a SH-protein. The molecular weight of the RNase inhibitor was estimated to be about 60,000.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1970.tb00510.x
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  • 2
    Electronic Resource
    Electronic Resource
    Developmental and regional variations in ribonuclease inhibitor activity in brain (1970)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 17 (1970), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1970.tb00520.x
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  • 3
    Electronic Resource
    Electronic Resource
    Rapid and accurate identification of microorganisms contaminating cosmetic products based on DNA sequence homology (2005)
    Oxford, UK : Blackwell Science Ltd
    International journal of cosmetic science 27 (2005), S. 0 
    Details
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to develop rapid and accurate procedures to identify microorganisms contaminating cosmetic products, based on the identity of the nucleotide sequences of the internal transcribed spacer (ITS) region of the ribosomal RNA coding DNA (rDNA). Five types of microorganisms were isolated from the inner portion of lotion bottle caps, skin care lotions, and cleansing gels. The rDNA ITS region of microorganisms was amplified through the use of colony-direct PCR or ordinal PCR using DNA extracts as templates. The nucleotide sequences of the amplified DNA were determined and subjected to homology search of a publicly available DNA database. Thereby, we obtained DNA sequences possessing high similarity with the query sequences from the databases of all the five organisms analyzed. The traditional identification procedure requires expert skills, and a time period of approximately 1 month to identify the microorganisms. On the contrary, 3–7 days were sufficient to complete all the procedures employed in the current method, including isolation and cultivation of organisms, DNA sequencing, and the database homology search. Moreover, it was possible to develop the skills necessary to perform the molecular techniques required for the identification procedures within 1 week. Consequently, the current method is useful for rapid and accurate identification of microorganisms, contaminating cosmetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-2494.2005.00285.x
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructure of transplant glomerulopathy (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 4 (1980), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thirty-one specimens of tissue were obtained from 15 renal allografts 3–96 months after transplantation and studied by light, electron and in some cases also by immunofluorescence microscopy. All patients had a degree of renal insufficiency and almost all had proteinuria and moderate hypertension; nephrotic syndrome was present in one and hematuria in two. On histological examination one patient showed cellular proliferation suggestive of glomerulonephritis (recurrent or de novo) and another patient had numerous crescents. The most frequent glomerular lesion was widening of the lamina rara interna with subendothelial accumulation of finely granular material, formation of new subendothelial basement membrane and deposition of microfibrils and fine filaments. The mesangial changes were mainly those of mesangiolysis and mesangial sclerosis with deposition of mesangial matrix and microfibrils, but little cellular proliferation. Fragmented red blood cells were seen in nearly half of the patients. In another seven patients the lesion resembled focal segmental glomerulosclerosis. This combination of changes termed transplant glomerulopathy leads to diffuse glomerular sclerosis. Arterial intimal thickening and occasionally also thrombosis produced ischaemic changes in the kidney and in the glomeruli and contributed significantly to the process of transplant rejection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1980.tb02931.x
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  • 5
    Electronic Resource
    Electronic Resource
    Dapsone suppresses human neutrophil superoxide production and elastase release in a calcium-dependent manner (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 152 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Dapsone (4,4′-diaminodiphenyl sulphone) is a powerful therapeutic tool in many skin diseases including neutrophilic dermatoses. The drug has an outstanding therapeutic efficacy against many skin diseases characterized by neutrophil-rich infiltrates; however, mechanisms of its action are poorly understood.Objectives  We investigated the effects of dapsone on respiratory and secretory functions of human neutrophils triggered by the chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), the physiological agonist C5a, and phorbol myristate acetate (PMA).Methods  Human neutrophils were isolated from venous blood obtained from healthy donors. We detected extracellular production of superoxide (O2–) by cytochrome C reduction assay, and intracellular production of O2– by flow cytometry. Neutrophil elastase release was measured by the cleavage of the specific elastase substrate N-methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide. Measurement of cytosolic free calcium concentration was performed using the calcium-reactive fluorescence probe, Fluo-3.Results  Dapsone suppressed intra- and extracellular production of O2– and elastase release triggered by fMLP and C5a, but not by PMA. Both fMLP and C5a signalled the above pathways by inducing calcium influx, but PMA functions bypassed calcium influx. Dapsone was capable of antagonizing the induction of calcium influx.Conclusions  These findings suggest that one mechanism of the anti-inflammatory action of dapsone is inhibition of calcium-dependent functions of neutrophils including release of tissue-damaging oxidants and proteases in the affected skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06559.x
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  • 6
    Electronic Resource
    Electronic Resource
    Spin-torque diode effect in magnetic tunnel junctions (2005)
    [s.l.] : Nature Publishing Group
    Nature 438 (2005), S. 339-342 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] There is currently much interest in the development of ‘spintronic’ devices, in which harnessing the spins of electrons (rather than just their charges) is anticipated to provide new functionalities that go beyond those possible with conventional electronic devices. One widely ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04207
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  • 7
    Electronic Resource
    Electronic Resource
    IMMUNOHISTOCHEMICAL STUDY OF α-FETOPROTEIN IN RAT EMBRYOS DURING ONTOGENESIS (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 417 (1983), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1983.tb32866.x
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of pseudo-network on physical properties of polyurethane (1974)
    Springer
    Rheologica acta 13 (1974), S. 139-148 
    Details
    ISSN: 1435-1528
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Summary Temperature dependent properties of some segmented copolyurethanes were compared with those of soft- and hard-segment polyurethanes. To understand the chemical nature of associated phase more explicitly, far-infrared spectral behaviors were precisely analyzed. Mid-infrared frequency shift of NH-stretching vibration of associated carbonamide group was taken as a measure of the strength of hydrogen bond. Dynamic viscoelastic response as well as flow property estimated from viscoelastic shift factor were compared with the infrared spectral behaviors. A strong intersegmental carbonamide association was found through a preferential “solvation” of —(CH2)6NHCOO— group in the soft segment derived from poly-butyleneglycoladipate (PBA) and hexamethylene diisocyanate (HMDI), to the same group in the hard segment derived from butanediol (BD) and HMDI, yielding a thermoplastic copolyurethane, (PBA + BD) —HMDI, with high activation energy of segmental flow. While, a unique aromatic association was observed in copolyurethane derived from diphenylmethane diisocyanate (MDI). A weakening of hydrogen bond in hard segment by aromatic cohesion of soft segment was observed from mid-infrared measurements, which gave a typical thermoelastic copolyurethane with moderate activation energy of flow. The same effect of weakening of hydrogen bond was observed by the replacement of polyester soft segment by less polar polyether, which gave also thermoelasticity. Polyurethanes derived from toluene diisocyanate (TDI) and xylylene diisocyanate (XDI) did not show the aromatic association of MDI type. The mid-infrared stretching vibration and farinfrared out-of-plane deformation vibration of associated NH-group were found to correlate with hydrogen bond- andvan der Waals-crystals having been assigned from (200) and (002) interferences, respectively, in X-ray scattering measurements byKilian et al.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01520867
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  • 9
    Electronic Resource
    Electronic Resource
    Inhibition of corn spermidine oxidase by acridine derivatives (1973)
    Springer
    Naturwissenschaften 60 (1973), S. 155-156 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00594790
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  • 10
    Electronic Resource
    Electronic Resource
    Lithium isotope separation by laser (1982)
    Springer
    Applied physics 28 (1982), S. 73-76 
    Details
    ISSN: 1432-0649
    Keywords: 35
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A lithium isotope separation was performed using a laser isotope separation method. It was found that the lithium atoms with a natural isotopic abundance enhanced its6Li concentration up to over 90% by tuning the laser wavelength to the2 P 1/2 of6Li. Too high power, however, leads to a loss of enrichment due to the power broadening effect which was analysed by the equation of motion of density matrices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00693895
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