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1

Digitale Medien

Carboxypeptidase activity in developing rat brain (1975)

Sarkar, D. ; Ghosh, J. J.

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 25 (1975), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1975.tb04397.x

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2

Digitale Medien

EFFECT OF DELTA-9-TETRAHYDROCANNABINOL ADMINISTRATION ON THE LIPID CONSTITUENTS OF RAT BRAIN SUBCELLULAR FRACTIONS (1975)

Sarkar, C. ; Ghosh, J. J.

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 24 (1975), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: An investigation on the effects of acute (10 mg/kg) and chronic (10 mg/kg for 15 days) treatment with Δ9-THC administration by the intraperitoneal route, on the cholesterol, cerebroside and individual phospholipid contents in microsomal, synaptosomal, mitochodrial and myelin fractions from adult rat brain, is reported. The drug has been found to affect the different subcellular membranous lipid and phospholipid components in a characteristic manner.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1975.tb11891.x

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3

Digitale Medien

IMIPRAMINE-INDUCED CHANGES OF BRAIN ADENOSINE TRIPHOSPHATASE ACTIVITY (1973)

Nag, D. ; Ghosh, J. J.

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 20 (1973), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract— Adenosine triphosphatase (ATPase) activities of brain microsomal and synaptosomal preparations are inhibited by imipramine [5-(3′-dimethylamino propyl)-10, 11-dihy-dro-5H-dibenz (b,f) azepine] in vitro, whereas microsomal ATPase activity is stimulated and synaptosomal ATPase activity remains unaltered under in vivo imipramine treatment. The inhibition of ATPase activity can to some extent be counteracted by spermine [N, N′-bis(3 aminopropyl)-1,4-butanediamine]. Determination of Km values from double reciprocal plots (activity-1 vs. ATP mM-1) under drug and spermine-treated conditions appear to indicate that spermine can to some extent imparta stabilizing effect mainly on the microsomal membrane ATPase, preventing inhibition in presence of imipramine in vitro, although spermine has no effect on the already destabilized membrane ATPase. Spermine exerts a stabilizing effect on membrane ATPase possibly by increasing the affinity of the enzyme for the substrate.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb00073.x

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4

Digitale Medien

EFFECT OF DELTA-9-TETRAHYDROCANNABINOL ON GANGLIOSIDES AND SIALOGLYCOPROTEINS IN SUBCELLULAR FRACTIONS OF RAT BRAIN (1976)

Sarkar, C. ; Ghosh, J. J.

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 26 (1976), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: —The present paper reports the result of studies undertaken to determine the effects of the in vivo administration of Δ9-THC on the ganglioside and sialoglycoprotein contents of rat brain subcellular fractions. Results indicate that the administration of the drug under both acute and chronic conditions brings about characteristic changes in the sialoglycoproteins and ganglioside content in all the subcellular fractions. Both sialoglycoproteins and ganglioside contents were markedly increased in microsomal and synaptosomal fractions and decreased in the mitochondrial fractions although the increase in the synaptosomal fractions has been found to be most striking.After chronic treatment, both ganglioside and sialoglycoprotein content did not change substantially in all the fractions except for a small increase in case of synaptosomal fractions.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb04442.x-i1

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5

Digitale Medien

Hepatic induction of threonine dehydratase and tryptophan pyrrolase in tyrotoxic rats (1977)

Datta, Kasturi ; Ghosh, J. J.

Springer

Cellular and molecular life sciences 33 (1977), S. 1018-1019

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ISSN: 1420-9071

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The levels of hepatic threonine dehydratase and tryptophan pyrrolase are elevated in 5% tyrosine-fed rats, and these increases are dependent on the dietary tyrosine level. Experiments with RNA and protein synthesis inhibitors indicate that the appearance of these new enzyme activities are dependet on concomitant new protein synthesis and the inducer operates at a transcriptional level.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01945942

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6

Digitale Medien

Mescaline-induced changes of brain-cortex ribosomes mescaline demethylase activity of brain-cortex soluble supernatant (1977)

Datta, R. K. ; Ghosh, J. J.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 296 (1977), S. 297-300

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ISSN: 1432-1912

Schlagwort(e): Brain-cortex slices ; O-demethylase ; Mescaline ; Soluble supernatant

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Brain-cortex slices demethylate mescaline and p-methoxyacetanilide, a reference O-demethylating substrate, though the rate of demethylation of mescaline is about one third that of the reference substrate. The demethylase activity is localized mostly in the soluble supernatant (105000xg). It is purified 47-fold with respect to the demethylation of mescaline by ammonium sulfate precipitation and DEAE cellulose chromatography. The partially purified demethylase, which is stable for 3–5 days at −5° C in the presence of dithiothreitol and glutathione and is inhibited by p-chloromercuribenzoate, has maximal activity at pH between 7.2 and 8.0. It demethylates mescaline into 3,4-dimethoxy-5-hydroxyphenethylamine and 3,5-dimethoxy-4-hydroxyphenethylamine and some unidentified derivatives.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00498697

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7

Digitale Medien

Mescaline-induced changes of brain-cortex ribosomes (1973)

Datta, R. K. ; Antopol, W. ; Ghosh, J. J.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 277 (1973), S. 319-322

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ISSN: 1432-1912

Schlagwort(e): Brain Ribosomes ; Mescaline ; Spermidine ; Polyphenylalanine Synthesis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Pre-treatment of brain cortex slices with mescaline causes decreased synthesis of polyphenylalanine by ribosomes isolated from drug-treated slices under the direction of messenger poly uridine not exposed to mescaline.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00505670

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