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  • 1
    Digitale Medien
    Digitale Medien
    Comment on a note by Winifred L. Wood (1974)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 430-431 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620080220
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  • 2
    Digitale Medien
    Digitale Medien
    Finite element analysis of plates with curved edges (1972)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 4 (1972), S. 49-65 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: The application of the high precision triangular plate bending element to problems with curved boundaries is considered. Appropriate edge conditions for nodal points on these boundaries are derived. The error inherent in representing the shape of a curved boundary by a series of straight segments is found to be the limiting factor on accuracy, while the effect of approximations in the actual boundary conditions is minor. To overcome the first type of error, the high precision element is modified to include one curved edge. Substantial improvements in accuracy are obtained, as demonstrated in example calculations for circular and elliptical plates.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620040108
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  • 3
    Digitale Medien
    Digitale Medien
    Evaluation of alclofenac treatment regimes in man (1973)
    Springer
    European journal of clinical pharmacology 6 (1973), S. 261-267 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Alclofenac ; antiphlogistic ; man ; pharmacokinetics ; dosage regimes ; plasma levels
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A one compartment open model has been found to fit plasma concentration data previously obtained in man after single oral doses of alclofenac; the parameters of the model are: $${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}} $$ abs=1.3±0.7h, $${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}} $$ el=3.5±1.2h, Vd/F=17±6. The model has been used successfully to predict steady-state plasma levels of alclofenac after multiple oral doses. One treatment schedule (initial dose 500 mg, maintenance dose 250 mg five times a day) was administered to two volunteers for five days and the plasma levels of alclofenac determined daily. The latter were in good agreement with computer predictions based on the model. It is now possible, therefore, to select the most suitable dosage regimes for this drug.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00644743
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  • 4
    Digitale Medien
    Digitale Medien
    Clindamycin bioavailability from clindamycin-2-palmitate and clindamycin-2-hexadecylcarbonate in man (1973)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 1 (1973), S. 89-98 
    Details
    ISSN: 1573-8744
    Schlagwort(e): clindamycin ; clindamycin-2-palmitate ; clindamycin-2-hexadecylcarbonate ; bioavailability ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract To determine the bioavailability of clindamycin from the microbiologically inactive clindamycin-2-palmitate and clindamycin-2-hexadecylcarbonate in man, a three-way crossover study was conducted with oral administration of the two esters and clindamycin hydrochloride. In each case, serum clindamycin bioactivity concentrations were fitted to a one-compartment open model with an initial lag time. Analysis of variance of measured quantities (serum concentrations and urinary excretion) and of derived pharmacokinetic parameters showed that for every comparison except maximum serum concentrations clindamycin-2-palmitate was not significantly different (at p=0.05) from clindamycin hydrochloride. Clindamycin-2-hexadecylcarbonate gave significantly different values from those for the hydrochloride in all cases except the rate constant and half-life for elimination from the serum. The palmitate was the superior ester and was bioequivalent to the hydrochloride in man.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01059623
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  • 5
    Digitale Medien
    Digitale Medien
    Discussion of paper by Bruce M. IronsBruce M. Irons, ‘A conforming quartic triangular element for plate bending’, Int. J. num. Meth. Engng, 1, 29-45 (1969). (1970)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 2 (1970), S. 453-454 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620020311
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  • 6
    Digitale Medien
    Digitale Medien
    Some comments on the equation block solver (1973)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 7 (1973), S. 227-228 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Zusätzliches Material: 1 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620070212
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  • 7
    Digitale Medien
    Digitale Medien
    Imperfections in axially loaded plane frames (1974)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 8 (1974), S. 847-864 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: A finite beam-column element computer program for the structural failure analysis of proportionally loaded skeletal plane frames is described. The program, which is based on an iterative stiffness approach, provides for non-linear elastic or plastic-non-linear elastic behaviour. Particular attention is given to the incorporation into the analysis of geometrical imperfections, return of elasticity at plastic hinges and negative frame stiffness. The effect of lack-of-fit displacements on the load-deflection path and failure load of frames that carry relatively large axial loads is described in general terms. The theory is developed further through the application of the computer program to two examples which show the necessity for the allowing for the effect of imperfections when designing axially loaded redundant frames.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620080412
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  • 8
    Digitale Medien
    Digitale Medien
    Dual analysis for heat conduction problems by finite elements (1972)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 5 (1972), S. 65-82 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: An alternative approach to the usual finite element treatment of steady-state temperature problems is presented, using approximations for the field of the dual variables.The appropriate extremum principle is established and its minimization is discussed in connection with a plane triangular finite element process. Original heat flow elements are derived: in conjunction with temperature elements, they enable dual analysis of a given structure and an important estimate of the convergence to the true solution by upper and lower bounds to the dissipation function, as illustrated by means of several examples.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620050107
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  • 9
    Digitale Medien
    Digitale Medien
    Pharmacokinetics and pharmacodynamics as well as metabolism following orally and intravenously administered C14-glipizide, a new antidiabetic (1973)
    Springer
    Diabetologia 9 (1973), S. 320-330 
    Details
    ISSN: 1432-0428
    Schlagwort(e): 14C-labelled glipizide ; pharmacokinetics ; pharmacodynamics ; metabolism ; protein-binding ; insulin concentration ; glucose determination
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Peak serum concentrations are reached after about 2 h following oral administration of 5 mg radioactive glipizide, and in the case of intravenous administration of 1 mg radioactive substance they are reached immediately following the injection. The half-life amounts to 36 min (compartment 1) and 3.6 h (compartment 2) resp. The distribution volume of the substance is11, 100 ml. — 5 metabolites were detected in the urine; 2 of them remained unidentified; the same metabolites could partly be detected in the serum. — As regards the insulin levels, two peaks can be seen following oral as well as following intravenous administration; the first peak is reached after absorption or after the injection as the case may be, the second one is reached at midday postprandially. — Of the orally administered substance, the greatest share of total activity eliminated in the urine is observed during the first 24 h, 65.2% of the administered activity are renally eliminated during 48 h. The corresponding value for 120 h being 65.4% after oral and 64.8% after intravenous administration. — These data verify complete absorption following oral administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01218442
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  • 10
    Digitale Medien
    Digitale Medien
    Pharmacological effects and serum levels of orally administered alprenolol in man (1972)
    Springer
    European journal of clinical pharmacology 5 (1972), S. 44-52 
    Details
    ISSN: 1432-1041
    Schlagwort(e): alprenolol ; serum drug level ; exercise ; man ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effects of alprenolol on heart rate and systolic blood pressure were studied in healthy subjects during standardized exercise on a bicycle ergometer. In one series of experiments, in which serum concentrations of alprenolol were also measured, the effects of single oral doses of 50, 100 and 200 mg of alprenolol and a placebo were compared by a double blind cross-over technique. In a second series of experiments 100 mg alprenolol was given four times in one day and the effect was followed for up to eighteen hours after the last dose. — Alprenolol diminished the expected increase in heart rate and systolic blood pressure during exercise. The reduction of exercise tachycardia in a given individual was linearly related to the logarithm of the dose or the serum concentration of alprenolol. The serum concentrations required for a given reduction of exercise tachycardia varied almost one hundred-fold amongst the subjects studied. The biological availability of alprenolol was dose-dependent, probably due to a limited capacity biotransformation of the drug before it entered the general circulation. After a single dose the serum level of alprenolol and its chronotropic effect diminished at a rate corresponding to an elimination half life of about two hours. This rate of elimination was consistent with that calculated from the results of the four dose study.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00560895
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