Electronic Resource
Springer
Archives of virology
39 (1972), S. 353-359
ISSN:
1432-8798
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Panosialin is a new type of metabolite, inhibiting sialidases of myxoand paramyxoviruses and various other enzymes under certain conditions. It also inactivated both hemagglutinating activity and infectivity of influenza virus. The inactivating activity of panosialin was more potent than that of sodium dodecyl sulfate or sodium dodecylbenzene sulfonate. Treatment with panosialin causes destruction of influenza virus particles to smaller particles of about 7 to 10 nm in diameter which can be shown by electron microscopy and by the lower sedimentation rate in ultracentrifugation. Panosialin apparently caused disruption of influenza virus particles. The effect of panosialin was reversed by the pretreatment with bovine albumin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01241014
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