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  • 1
    Electronic Resource
    Electronic Resource
    Effects of Industrial Development on Heads of Households (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Growth and change 4 (1973), S. 0 
    Details
    ISSN: 1468-2257
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geography , Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-2257.1973.tb00256.x
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  • 2
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    Unknown
    CONFLICT CHANGE AND STABILITY: A Reciprocal Interaction in Schools (1974)
    Chapel Hill, N.C. : Periodicals Archive Online (PAO)
    Social Forces. 52:4 (1974:June) 517 
    Details
    ISSN: 0037-7732
    Topics: Sociology
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1203-1974-052-04-000009
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  • 3
    Electronic Resource
    Electronic Resource
    Abtransport und Abbau von Benzo(a)pyren nach intratrachealer Injektion (1970)
    Springer
    Journal of cancer research and clinical oncology 75 (1970), S. 14-22 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter bestimmten Voraussetzungen wird nach intratrachealer Injektion Benzo(a)pyren mit dem Blut abtransportiert und in der Leber abgebaut. Außerdem erfolgt ein Abbau in der Lunge selbst. Dieser Abbau scheint an einen bestimmten Zelltypus, die Alveolar-Makrophagen gebunden zu sein, worauf die in vitro-Untersuchungen hinweisen.
    Notes: Summary After intratracheal injection under special conditions benzo(a)pyrene is eliminated by the blood stream and metabolized principally in the liver; some, however, is metabolized in the lungs as well, apparently by the alveolar macrophage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00524740
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  • 4
    Electronic Resource
    Electronic Resource
    Molecular deficiencies of human blood coagulation (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1-7 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Blut gerinnt, wenn das Gerinnungsferment Thrombin aktiviert wird und Fibrinogen in Fibrin umwandelt. Störungen der Thrombin- oder Fibrinbildung können Bluterkrankheiten verursachen. Die Ursache angeborener Bluterkrankheiten liegt entweder in der quantitativen Verminderung oder in qualitativen Strukturanomalien eines Gerinnungsfaktors. Immunologische Methoden im Verein mit einer beginnenden, direkten Strukturabklärung zeigten für das Fibrinogen überzeugend, dass beide Möglichkeiten vorkommen. Unterschiedliche Funktionsausfälle von Fibrinogen lassen vermuten, dass verschiedenartigen Strukturanomalien für Störungen der Substrateigenschaften gegenüber Thrombin, der Polymerisierung oder der Fibrinstabilisierung verantwortlich sind. Ähnliche Untersuchungen an den Faktoren II, VII, VIII, IX, X und XIII zeigen, dass wahrscheinlich die Mehrzahl der bekannten Bluterkrankheiten durch Strukturanomalien verursacht werden. Die eingehende Untersuchung solcher Strukturdefekte wird zukünftig um so interessanter und bedeutungsvoller werden, je besser die Struktur und Funktion der normalen Gerinnungsfaktoren bekannt sind.
    Notes: Summary Blood coagulation reflects, the complex biological system resulting in the formation of thrombin and the subsequent conversion of fibrinogen into fibrin. Disorders of either thrombin or fibrin formation may cause bleeding states. Congential hemorrhagic disorders are characterized by either reduction of a coagulation factor or impairment of its functional capacity by structural aberrations. Immunological studies and direct molecular evaluation of fibrinogen demonstrate that both types of abnormalities occur. Functional evaluation of abnormal fibrinogens suggests that many different structural variants exist and variably influence interaction with thrombin, fibrin polymerization and fibrin ‘stabilization’. Similar studies performed on factors II, VII, VIII, IX, X and XIII indicate that qualitative abnormalities are more frequent than ‘true’ deficiency states. Such molecular abnormalities will become increasingly interesting and important as the biochemistry of normal coagulation progresses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01928228
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  • 5
    Electronic Resource
    Electronic Resource
    Heme synthetase in thalassemia (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 193-193 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Hämsynthetase (HS)-Aktivität zirkulierender Retikulozyten und Erythrozyten von Normalspendern und Patienten mit Thalassämie wurde in vitro bestimmt. HS war normal oder erhöht bei Thalassämie. Jugendliche, über das Stadium des Retikulozyten hinaus gereifte Erythrozyten enthalten wahrscheinlich noch einen signifikanten Anteil der im peripheren Blut messbaren HS-Aktivität.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01935753
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  • 6
    Electronic Resource
    Electronic Resource
    The role of histamine and catecholamines in anaphylatoxin shock as compared to the anaphylactic shock (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 266 (1970), S. 208-222 
    Details
    ISSN: 1432-1912
    Keywords: Anaphylatoxin ; Anaphylaxis ; Histamine ; Catecholamines ; β-Adrenergic Blockade ; Anaphylatoxin ; Anaphylaxie ; Histamin ; Katechol amine ; β-adrenergische Blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. In the heart lung preparation (HLP) of the guinea pig 2.5 ml rat serum anaphylatoxin (AT) released approximately ten times less histamine than was released by 5 mg ovalbumin in the sensitized HLP. In intact animals the plasma histamine increase caused by 5 ml/kg AT was not significantly different from that caused by 10 mg/kg ovalbumin. It is supposed that in AT shock extrapulmonary sources contribute to plasma histamine more than in anaphylactic shock. 2. Mepyramine maleate (40 μg/ml blood) did not significantly reduce the bronchospasm caused by AT in HLP except when a very high AT dose (0.3 ml/ml) was given. In the intact animal, mepyramine lowered the AT-induced bronchospasm by 50–65%. This effect of mepyramine is completely abolished byβ-adrenoceptive receptor blockade. 3. It is concluded that the prevalence of histamine effects in AT shock in vivo, as documented by the life saving effect of antihistamines, is due to 2 facts: influx of histamine from the organs other than the lung, and preferential antagonism by catecholamines of such shock mechanisms which are not based on histamine release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997283
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  • 7
    Electronic Resource
    Electronic Resource
    Synergistic effects of adrenaline and mepyramine on the anaphylactic reactions of the bronchi and pulmonary vessels in the guinea pig heart-lung-preparation (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 267 (1970), S. 224-240 
    Details
    ISSN: 1432-1912
    Keywords: Anaphylaxis ; Histamine ; Antihistaminics ; Cateoholamines ; Pulmonary Circulation ; Bronchospasm ; Anaphylaxie ; Histamin ; Antihistaminica ; Katecholamine ; Lungenkreislauf ; Bronchospasmus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. In the guinea pig heart-lung-preparation (HLP) anaphylactic bronchospasm was not greatly affected by mepyramine (2–40 μg/ml blood), adrenaline (0.1 and 1 μg/ml), noradrenaline (0.1 μg/ml) or papaverine (100 μg/ml) but was completely abolished by combining mepyramine with the lower dose of adrenaline. A partial antagonism was achieved by the combined action of mepyramine and papaverine which became complete when adrenaline was added. 2. Bronchospasm due to histamine was completely prevented by mepyramine, but only partially antagonized by both adrenaline doses used. 3. The increase of pulmonary vascular resistance in anaphylaxis was not inhibited by the highest tolerated amounts of mepyramine or papaverine, no matter whether the drugs were given alone or in combination. Adrenaline, in contrast to noradrenaline, was partially effective at the lower dose (0.1 μg/ml). The higher concentration did not act more strongly. It became fully effective when mepyramine was added either alone or combined with papaverine. 4. The increase of pulmonary vascular resistance induced by histamine was strongly and significantly antagonized by mepyramine alone as well as by the lower concentration of adrenaline (0.1 μg/ml). Noradrenaline had no significant effect in either amount given (0.1 and 1 μg/ml). 5. Antigen increased heart rate in sensitized HLPs, probably due to histamine release. This effect was resistant to mepyramine. 6. The present findings are discussed a) with respect to the refractoriness of the anaphylactic bronchospasm to mepyramine, an effect displayed in isolated lung preparations but not in intact animals. b) with respect to the mechanism of the so-called protracted shock which is mainly due to heart failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997094
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  • 8
    Electronic Resource
    Electronic Resource
    Behandlungsergebnisse von suprakondylären, bikondylären und diakondylären Oberschenkelbrüchen bei Erwachsenen (1972)
    Springer
    Archives of orthopaedic and trauma surgery 74 (1972), S. 91-104 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über Behandlungsverfahren und Nachuntersuchungsergebnisse bei suprakondylären, bikondylären und diakondylären Oberschenkelbrüchen Erwachsener berichtet. Während die konservative Behandlung bei supra- und diakondylären Oberschenkelbrüchen gute Ergebnisse bringt, stellt der bikondyläre Oberschenkelbruch eine Domäne der Osteosynthese dar. Dabei sollte eine Übungsstabilität angestrebt werden. Wenn dem Verletzten ein größerer operativer Eingriff nicht zugemutet werden kann, bietet die Minimalosteosynthese mit percutan gekreuzten Bohrdrähten oder Spongiosaschraube in Verbindung mit der Extensionsbehandlung die besten Ergebnisse.
    Notes: Summary Management and follow-up results of supracondylar, bicondylar and dicondylar fractures of the femur are reported. Conservative treatment of supracondylar and dicondylar fractures can produce good results. Rigid internal fixation is the method of choice for treatment of bicondylar fractures. Patients with bicondylar fractures who cannot undergo maior surgery because of bad physical conditions should be treated by percutaneous internal fixation using Kirschner wires or cancellous screws combined with skeletal traction through the upper end of the tibia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00415268
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  • 9
    Electronic Resource
    Electronic Resource
    Extremitätendurchblutung und Venenkapazität nach Unterschenkelfraktur: venenverschlußplethysmographische Untersuchungen (1973)
    Springer
    Archives of orthopaedic and trauma surgery 77 (1973), S. 195-202 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 10 Patienten wurde die arterielle und venöse Hämodynamik 69 bis 175 Tage nach Unterschenkelfraktur mit einer venenverschlußplethysmographischen Methode überprüft. 90,1±16,7 bzw. 120,3±16,5 Tage nach der Fraktur war die Durchblutung der erkrankten Seite im Bereich des Unterschenkels um +4,27±1,93 (p〈0,005) (+197%) bzw. +3,94±1,45 (p〈0,001) ml/100 ml Gewebe/min und im Bereich des Fußes um +0,54±0,68 (p〉0,05) (+76%) bzw. +3,39±1,24 (p〈0,001) (+424%) ml/100 ml Gewebe/min gesteigert (Vergleich mit kontralateraler Seite). Zu denselben Meßzeitpunkten war die druckabhängige Venenkapazität des erkrankten Unterschenkels um −1,32±0,61 (p〈0,005) (−38%) bzw. −0,98±1,49 (p〉0,05) (−32%) ml/100 ml Gewebe vermindert (Vergleich mit der kontralateralen Seite).
    Notes: Summary In 10 patients arterial and venous hemodynamics of the leg have been examined 69 to 175 days after fracture of the tibia using venous occlusive plethysmography. 90.1±16.7 and 120.3±16.5 days after the fracture, respectively, the bloodflow of the injured calf was increased by +4.27±1.93 (p〈0.005) (+197%) and +3.94±1.45 (p〈0.001) ml/100 ml tissue/min, respectively, whereas the bloodflow at the foot was increased by +0.54±0.68 (p〉0.05) (+76%) and by +3.39±1.24 (p〈0.001) (+424%) ml/100 ml tissue/min, respectively (as compared with the contralateral side). At the same time the venous capacity of the calf was decreased by −1.32±0.61 (p〈0.005) (−38%) and by −0.98±1.49 (p〉0.05) (−32%) ml/100 ml tissue, respectively (as compared with the contralateral side).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00416548
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  • 10
    Electronic Resource
    Electronic Resource
    Erhärtungsverlauf und Endfestigung verschiedener Gipsverbände (1974)
    Springer
    Archives of orthopaedic and trauma surgery 78 (1974), S. 286-290 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit den vorgefertigten Gipsbinden Cellona®, Gypsona® und Platrix® wurden genormte Probekörper hergestellt und nach festgesetzten Trocknungszeiten Biegeund Scheiteldruckversuche durchgeführt. Nach 90 min steigt die Festigkeit deutlich an und erreicht nach 120 min einen Endwert. Die Werte sind für alle drei Gipsverbände etwa gleich.
    Notes: Summary With the prepared plasterbandages Cellona®, Gypsona® and Platrix® standardized test models were mouldet and after fixed drying times bending stresses and peak stress loadings were measured. After 90 min there was a marked increase in firmness and after 120 min the endresult was reached. The result of all three plasters bandages was similar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00415808
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