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  • 1970-1974  (9)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of cyclophosphamide on a local graft-versus-host reaction in the rat: Influence of sex, disease and different dosage regimens (1973)
    Springer
    Inflammation research 3 (1973), S. 53-60 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A new pharmacological method for screening potential immunosuppressive drugs, the local graft-versus-host reaction in rats, has been used to evaluate the efficacy of cyclophosphamide applied at varous times in the development of this reaction. This drug was relatively ineffective when applied to the F1 hybrid recipient of the graft cells (splenic lymphocytes) prior to grafting, rather more effective when given only to the parental donor prior to harvesting the graft cells, and most effective when given to the recipient either immediately after the graft or after a delay of three days. Biliary and hepatic metabolites of cyclophosphamide diminished the competence of parental lymphocytes to evoke the graft response. By contrast, cyclophosphamide itself was devoid of such activity in vitro. Non-enzymic decomposition (hydroxylation) of cyclophosphamide with the Udenfriend system (Fe++, ascorbate, EDTA) efficiently generated in vitro graft-deactivating agents. Fortified liver preparations from normal female rats formed alkylating metabolites at a much slower rate, and adjuvant-arthritic male rats were less capable of generating graft deactivating cyclophosphamide metabolites in vitro, than liver preparations from normal male rats. However cyclophosphamide appeared to be no less effective in normal female or arthritic male rats in vivo, than in normal male rats, in controlling the graft-versus-host response. This lack of correlation between rates of hepatic cyclophosphamide metabolism and evident bioefficacy as an immunosuppressive drug is discussed, with special reference to similar findings by Sladek concerning rates of bioactivation and anti-tumor efficacy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02023854
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  • 2
    Electronic Resource
    Electronic Resource
    Some (pharmacological) properties of chloracetaldehyde, an oxidation product and potential metabolite of cyclophosphamide (1974)
    Springer
    Inflammation research 4 (1974), S. 34-43 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Circumstantial evidence is presented that chloracetaldehyde is generated from cyclophosphamide by chemical oxidation in vitro with peroxide and might possibly be formed in vivo as a product of cyclophosphamide bioactivation. Chloracetaldehyde has several attributes of an agent capable of suppressing cellular immunity. Thus it prevents a graft-versus-host reaction (both in vivo and in vitro), is cytostatic and under certain conditions can abrogate an ongoing immunopathy (EAE). These properties are also exhibited by HN-2 and certain alkylating metabolites of cyclophosphamide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965490
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Approximation of Green's functions (1970)
    Springer
    The European physical journal 239 (1970), S. 276-288 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Special symmetries of the Green's functions of a non-relativistic many fermion-system and conservation laws, expressible by hermitian generators, are formulated as relations for a Green's function operator. Approximations for the Green's functions, defined as partial summations of the perturbation expansion, and consistent with the symmetries and conservation laws are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01398117
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  • 4
    Electronic Resource
    Electronic Resource
    Electrosynthesis of adiponitrile in undivided cells (1972)
    Springer
    Journal of applied electrochemistry 2 (1972), S. 59-69 
    Details
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract It has been shown that adiponitrile can be synthesized in undivided cells under favourable conditions. Because of strong decomposition of the quaternary ammonium salt support electrolyte, its concentration must be kept at a very low level. To avoid excessive resistance of the cell, the distance between the electrodes must then be smaller than 0·5 mm. We have developed various types of such cells. The ‘capillary gap cell’ is simple in design and can be readily scaled up. Continuous operation is possible. Yields of about 90% of adiponitrile have been obtained. The energy consumption is less than 3 kWh/kg product. Work up of the solutions is greatly facilitated by the low salt concentrations. It has been shown that the anodic oxidation of isopropanol, which is used as cosolvent, is strongly influenced by the acrylonitrile present. A substantial portion of the isopropanol is oxidized to CO2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00615193
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  • 5
    Electronic Resource
    Electronic Resource
    Bifunktionelle Verbindungen durch Kolbe-ElektrolyseVortrag vor der GDCh-Fachgruppe „Angewandte Elektrochemie“, 6. bis 8. Oktober 1969 in Bonn. (1970)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 42 (1970), S. 170-175 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Zur Synthese bifunktioneller organischer Verbindungen bietet die Kolbe-Elektrolyse viele Möglichkeiten, die jedoch bisher technisch kaum genutzt wurden. In dieser Arbeit wird die Elektrolyse von Di-, Amino- und Oxycarbonsäuren näher untersucht. Die hierfür entwickelte Vibratorzelle erlaubt es, trotz der starken Gasentwicklung während der Reaktion, mit einem geringen Elektrodenabstand und folglich mit einer niedrigen Zellspannung zu arbeiten. Die Abhängigkeit der Ausbeuten vom Substrat und den Elektrolysebedingungen, wie Neutralisationsgrad, Stromdichte und Lösungsmittel, wird an einigen Beispielen aufgezeigt.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330420404
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  • 6
    Electronic Resource
    Electronic Resource
    Entwicklungsstand der Elektrosynthese organischer VerbindungenVortrag vor der GDCh-Fachgruppe „Angewandte Elektrochemie“, 6. bis 8. Oktober 1969 in Bonn. (1970)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 42 (1970), S. 153-164 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Bei der Elektrosynthese organischer Verbindungen ist es von Vorteil, daß die Selektivität und damit die Ausbeute hoch ist, daß man stöchiometrische Parallelprodukte vermeidet und den Prozeß leicht automatisieren kann und daß man schließlich Normaldruck und Raumtemperatur als Verfahrensparameter hat, wodurch die breite Anwendung von Kunststoffen und Ionenaustauscher-Membranen möglich ist. Viele spezifische Probleme bezüglich der Elektroden, des Elektrolyten, des Lösungsmittels, der optimalen Zellenkonstruktion und nicht zuletzt der Kosten für die Elektroenergie konnten in der letzten Zeit gelöst werden. Dies wird an einigen Beispielen, wie der Elektrosynthese von Adipinsäuredinitril, von Bleialkylen, von Sebacinsäureester und von Salicylaldehyd, aufgezeigt. Die Elektrosynthese von Adipinsäuredinitril demonstriert auch, welche Umstände die Einführung eines elektrochemischen Verfahrens zwingend erscheinen lassen und gegen welche Konkurrenzverfahren dieses sich im Laufe der Zeit behaupten muß.
    Additional Material: 16 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330420402
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  • 7
    Electronic Resource
    Electronic Resource
    Elektrotauchlackierung. Von W. Machu. Verlag Chemie GmbH, Weinheim/Bergstr. 1974. l. Aufl., X, 338 S., 133 Abb., 32 Tab., Ln. DM 98,- (1974)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 46 (1974), S. 879-880 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330462015
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  • 8
    Electronic Resource
    Electronic Resource
    Techniques of Electrochemistry. Vol. 1. Von E. Yeager u. A. J. Salkind. Wiley-Interscience, New York - London 1972. 1. Aufl., IX, 581 S., div. Abb. u. Tab., geb. £ 11.70 (1974)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 86 (1974), S. 385-386 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19740861014
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  • 9
    Electronic Resource
    Electronic Resource
    Book Review: Techniques of Electrochemistry. Vol. 1. By E. Yeager and A. J. Salkind (1974)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 13 (1974), S. 355-356 
    Details
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.197403553
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