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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 25 (1973), S. 307-312 
    ISSN: 1432-0533
    Keywords: Perinatal Telencephalic Leucoencephalopathy ; Chimpanzee ; Mucopolysaccharid Deposits ; Glial Reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Parenchymal deposits with the histochemical characteristics of acid glycosaminoglycans were discovered in the brains of 12 chimpanzees ranging from 6 months gestational age to 17 months post partum. Similar deposits were not seen in the brains of one fetus of approximately 3 1/2 month gestational age or in the brains of three animals that were 10 or more years of age. The deposits were found primarily in thecapsula interna, lentiform nucleus, andcapsula externa. Only a few deposits were located in the thalamus. In most instances, the mucopolysaccharid deposits were surrounded by accumulations of glial cells indicating a weak to moderate glial reaction.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adult African green monkeys and young baboons were inoculated with a baboon-derived herpesvirus (0430) which is antigenically related to herpesvirus SA8. The African green monkeys were not clinically affected, but virus could be recovered from explants. In baboons, pathogenicity was inversely related to age. In intratracheally-inoculated newborns and, to a lesser extent, in intravenously-inoculated newborns, the virus produced severe disease accompanied by weight loss, anorexia, malaise, dyspnea and fever. In 2-month and 1-year-old baboons, the virus produced no clinical symptoms. In all cases, recovery of virus from explants was superior to recovery from tissue homogenates using routine methods.
    Type of Medium: Electronic Resource
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