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  • 1
    Electronic Resource
    Electronic Resource
    Demonstration in mouse of X-ray induced deletions for a known enzyme structural locus (1974)
    [s.l.] : Nature Publishing Group
    Nature 248 (1974), S. 416-418 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] TABLE 1 MOD-2 phenotypes of individuals produced by crossing coh/c* to SM/J mice. a b Genotype of original cch/c* individual Untyped I "\ offspring cch/ Typed I i\ offspringc*/ + MOD-2AB MOD-2A MOD-2AB MOD-2A MOD-2AB MOD-2A cwcos Mod-2? 11 0 0 2 0 cch Mod-2b C"H ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/248416a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Gene dosage in a deletion for a nuclear-coded, mitochondrial enzyme (1974)
    [s.l.] : Nature Publishing Group
    Nature 248 (1974), S. 418-419 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has been demonstrated that in two lethal albino alleles (c6H and c25H) which cause early embryonic death the deletion extends to the adjacent structural locus for mitochondrial malic enzyme (Mod-2 EC 1.1.1.40, L-malate NADP oxidoreductase, decarboyxlating)7. We compared malic enzyme activity in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/248418a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Erythrocytic nicotinamide-adenine dinucleotide phosphate levels and the genetic regulation of erythrocytic glucose 6-phosphate dehydrogenase activity in the inbred mouse (1974)
    Springer
    Biochemical genetics 11 (1974), S. 33-40 
    Details
    ISSN: 1573-4927
    Keywords: mice ; erythrocyte ; glucose 6-phosphate dehydrogenase ; nicotinamideadenine dinucleotide phosphate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract NADP measurements in erythrocytes of eight inbred strains of mice showed a correlation between low NADP and low erythrocytic G6PD levels. In vitro heat inactivation tests indicated that the NADP differences found could explain the previously demonstrated lability of G6PD in the erythrocytes of the low G6PD activity strain, C57L/J. Breeding experiments suggested a common genetic control of erythrocytic NADP levels and G6PD activity in crosses between intermediate and low strains, but an effect of sex and other variables, as yet unidentified, precluded a strong demonstration of unitary genetic control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00486617
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  • 4
    Electronic Resource
    Electronic Resource
    Chemical and immunological studies of liver microsomes from mouse mutants with ultrastructurally abnormal hepatic endoplasmic reticulum (1974)
    Springer
    Biochemical genetics 12 (1974), S. 81-95 
    Details
    ISSN: 1573-4927
    Keywords: mouse mutant microsomes ; biochemical analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Investigations of the lethal effects of a series of radiation-induced deletion alleles in the mouse have identified severe ultrastructural abnormalities of endoplasmic reticulum liver membranes in lethal albino homozygous newborns. The ultra-structural defects were accompanied by deficiencies of several enzymes, some of them microsomal membrane bound. Chemical and immunological studies were therefore undertaken in order to identify a possible biochemical alteration of mutant endoplasmic reticulum membranes. Patterns of gel electrophoresis produced by several different methods showed no differences between the microsomal proteins of mutant and normal mice. Immunological methods also failed to detect any changes in the major proteins. Thus in spite of the severe ultrastructural defects no major differences between microsomal proteins of mutant and normal membranes could be identified. Since several of the enzymes affected are inducible by cAMP in newborn mice, microsomal and supernatant cAMP-binding activities were also measured in mutants and normals but showed no differences. As yet, the primary cause of the severe effects of the X-ray-induced deletions on membrane structure and enzyme activities remains unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00487530
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    Paper (German National Licenses)
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