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  • 1
    Electronic Resource
    Electronic Resource
    Deconvolution method for identification of peaks in digitized spectra (1973)
    s.l. : American Chemical Society
    Analytical chemistry 45 (1973), S. 2239-2247 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60335a001
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Indomethacin: Plasma concentrations and protein binding in man (1972)
    Springer
    European journal of clinical pharmacology 4 (1972), S. 119-124 
    Details
    ISSN: 1432-1041
    Keywords: Indomethacin ; protein-binding ; salicylic acid ; plasma kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The fluorometric method of Holt & Hawkins (1965) has been modified to permit determination of 50 ng indomethacin in 0.5 ml plasma, by measuring its fluorescence in a phosphate buffer at pH 11.6 instead of sodium hydroxide. The method has also been adapted to show the presence of salicylic acid and a column chromatographic method has been devised for its removal. The protein binding of indomethacin in human plasma was calculated to be about 90% from an association constant of 0.86×103 M−1 (M=molarity). The number of binding sites on albumin is about 15. The plasma levels of indomethacin in patients receiving continuous treatment with Indocid® were between 0.5 and 3 µg/ml during the 4–5 h immediately after the last dose of 25 mg. The disappearance of indomethacin from plasma appears to consist of a fast primary phase at plasma concentrations greater than 1 µg/ml (T 1/2 about 90 min.), and a slower secondary phase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562508
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of indomethacin on the distribution of cortisol in man (1971)
    Springer
    European journal of clinical pharmacology 3 (1971), S. 102-105 
    Details
    ISSN: 1432-1041
    Keywords: Indomethacin ; cortisol ; protein-binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Simultaneous determinations of free and protein bound plasma cortisol and of the concentrations of cortisol in skin biopsies were performed after treatment with indomethacin. Neither after a single dose nor in patients on continuous treatment, were any consistent changes found in the protein binding of plasma cortisol. However, in patients treated for more than 3 weeks a significantly greater number of skin biopsies were observed with very low concentrations of cortisol. No relation between the free fraction of plasma cortisol and the tissue cortisol could be demonstrated.In vitro experiments showed no alteration of the protein binding of cortisol after the addition of indomethacin to plasma. It is concluded that indomethacin does not have antirheumatic activity because of displacement of the protein bound plasma cortisol as proposed by other workers. However, long term treatment with indomethacin does seem to influence the tissue distribution of cortisol. The possible relationship of this observation is discussed in view of reported fatalities after long continued indomethacin treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00619302
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  • 4
    Electronic Resource
    Electronic Resource
    Maintained Function of Foreign Synapses on Hyperinnervated Skeletal Muscle Fibres of the Rat (1974)
    [s.l.] : Nature Publishing Group
    Nature 247 (1974), S. 375-376 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The superficial fibular nerve, which normally innervates flexor muscles in the lower leg, was used as the foreign nerve in our experiments. It was dissected, cut peripherally, and transplanted into the proximal surface of the soleus muscle of young rats. Two weeks later the soleus was deprived of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/247375a0
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  • 5
    Electronic Resource
    Electronic Resource
    Excited states in195Pt from the decay of 2.3h195Irg, 3.7h195Ir m and 183d195Au (1973)
    Springer
    The European physical journal 261 (1973), S. 95-116 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The decay of two previously reported isomers in195Ir has been investigated with Ge(Li) and Si(Li) detectors by observing β and γ rays as well as conversion electrons in single and coincidence measurements. To about 30 of the 85 observed transitions a multipolarity was assigned. The energies of the gamma rays from195Au were also determined accurately. The decay scheme of195Ir shows 13 new levels in195Pt between 389 and 931 keV. Probable spin and parity assignments could be made to most levels. The results are compared with those of a recent Coulomb excitation study, reaction work and theoretical calculations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01394552
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