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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 51 (1973), S. 529-532 
    ISSN: 1432-1440
    Keywords: Epidemiology ; virology and virological diagnosis of CMV infections ; Epidemiologie ; Virologie und virologische Diagnose der Cytomegalie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Cytomegalie ist über die ganze Welt verbreitet. Das Virus persistiert nach der Infektion trotz hoher Serumantikörpertiter und die Antikörperträger sind potentielle Infektionsquellen. Die Durchseuchung der Bevölkerung ist regional unterschiedlich und schwankt zwischen 40% in den Industrieländern und 100% in den Entwicklungsländern. Das Virus gehört in die Herpesgruppe. Die Virusvermehrung wird in vitro durch Brom- und Jod-desoxyuridin (Floxuridine) gehemmt, ohne daß diese Substanzen für die klinische Therapie zu überzeugenden Resultaten geführt haben. Die virologische Diagnose durch Erreger- und Antikörpernachweis ist wesentlich empfindlicher und spezifischer als das cytologisch/histologische Nachweisverfahren.
    Notes: Summary Infections with cytomegalovirus are common in all parts of the world. The virus may persist for many years in presence of high serum-antibody levels and infections may be transmitted by antibody-carriers. The proportion of antibody-carriers varies between 40% in advanced countries and 100% in some developing countries. CMV is a member of the herpes-group. Virus-propagation is inhibited in vitro by substances like Flox-uridine, but no convincing results have as yet been obtained in clinical trials. The diagnosis by virus isolation and antibody-demonstration is a reliable and reproducible method; it is more sensitive than the demonstration of inclusion bodies by cytological methods.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of virology 33 (1971), S. 288-295 
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antigenic relationship between CMV, HSV, and VZV viruses was studied by the complement-fixation. 47 sera from congenitally infected children excreting CMV regularly possessed homologous antibodies, mostly at titers of 1 in 60 or more. HSV antibodies were found in 9 sera from children older than one year, but only 3 sera showed antibody titers of 1 in 60 or more. VZV antibodies were detected, at low titers, in 3 sera from infants under one year of age. Six sera from adults with postnatal CID excreting CMV showed regularly both CMV and HSV antibodies, although CMV antibodies were of slightly higher titers. VZV antibodies were found in 2 adults at low titers. Paired sera from 4 patients with significant titer rises against CMV did not show titer rises against heterologous antigens. Also, 4 serum pairs from patients with titer rises against HSV did not cross-react with either CMV or VZV antigens.
    Type of Medium: Electronic Resource
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