ISSN:
1432-1912
Keywords:
Pepstatin
;
Renin-Angiotensin System
;
Nephrectomy
;
Proteinase Inhibitor
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Pepstatin, an N-acylated pentapeptide isolated from culture filtrates of streptomycetes, has been shown in previous experiments to inhibit the reninsubstrate reaction in vitro. On the basis of blood-pressure measurements in the rat it is suggested that pepstatin affects the reaction of both endogenous and exogenous heterologous renin with plasma substrate. Besides this effect, pepstatin has a slight non-specific hypotensive action, as demonstrated in the nephrectomized rat.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00505072
Permalink