ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
—In order to study changes of the glycolytic-respiratory system and amino acid metabolism associated with blood flow disturbance, the cat brain perfusion was conducted with artificial blood containing [U-14C]glucose and the results were compared with those of standard perfusion keeping the cerebral blood flow at constant rate. The findings of the present study are briefly summarized:(1) In blood flow disturbance there was observed an accumulation of lactate just as seen in the low functional state observable in the standard perfusion. However the increase in relative specific activity of lactate was not so marked as the rise in cerebral lactate content, and this indicates that there is an increase of lactate production from substrates other than glucose as well as an increase of net flow of glucose carbon to lactate.(2) In blood flow disturbance relative specific activities of glutamate, aspartate, glutamine and respiratory CO2 were decreased as compared with those in the brain of high functional state. The relative specific activity of GABA in the reduced blood flow brain was at the same level as that of the brain at high functional state and it was higher than the relative specific activity of glutamate.(3) The relative specific activity and content of alanine were increased in the low function brain with standard perfusion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1970.tb03727.x
Permalink
