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  • 1970-1974  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Drug Research and Human Sleep (1973)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 13 (1973), S. 243-252 
    Details
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.pa.13.040173.001331
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Debrisoquine, guanethidine, propranolol and human sleep (1971)
    Springer
    Psychopharmacology 21 (1971), S. 101-110 
    Details
    ISSN: 1432-2072
    Keywords: Sleep ; Noradrenaline ; Debrisoquine ; Overdose ; Guanethidine ; Propranolol ; β-Blockers ; Isoprenaline ; Dexamphetamine ; Imipramine ; MAOI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Debrisoquine in dosage of 20–60 mg continued for up to 10 days caused suppression of human paradoxical sleep and withdrawal rebound, and also increased intra-sleep restlessness. An overdose of debrisoquine 200 mg caused suppression of paradoxical sleep and a rebound of over 2 weeks duration. Guanethidine 20–40 mg for 21 days did not affect paradoxical sleep but increased intra-sleep restlessness and reduced stages 3 + 4 sleep. Propranolol 120 mg had no discernable effect on sleep and did not prevent actions of dexamphetamine sulphate 10 mg nor of imipramine 75 mg. The findings relate to theories of cerebral noradrenaline in the control of sleep mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572267
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The effects of perlapine on sleep (1973)
    Springer
    Psychopharmacology 32 (1973), S. 1-9 
    Details
    ISSN: 1432-2072
    Keywords: Sleep ; Perlapine ; Hypnotic ; EEG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Perlapine is a new hypnotic and in a pilot study of its effects on the sleep of two normal subjects 10 mg decreased intra-sleep restlessness (frequency of shifts into stage 1 sleep or wakefulness) and also decreased paradoxical sleep duration, but did not alter stages 3+4 sleep. A more extended study consisted of a baseline week, three weeks of drug and two withdrawal weeks. Three men took 10 mg and two men 20 mg of perlapine nightly. The decrease of intra-sleep restlessness and the absence of suppression of stages 3+4 were confirmed. Time spent in drowsiness and wakefulness were reduced. Paradoxical sleep was reduced in duration, with a short-lasting rebound. The 20 mg dose appeared to increase the duration of stages 3+4 sleep in the first week.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421703
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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