ISSN:
1433-8580
Keywords:
Amyloid fibril protein
;
Immunoglobulin light chain
;
Localized amyloidosis
;
Lung
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The major protein of an amyloid fibril concentrate from a patient with localized nodular pulmonary amyloidosis has been purified by sequential gel filtration on Sepharose 4 B and Sephadex G-100 columns using 5 M guanidine-HCl in 1 N acetic acid. The molecular weight of 15250, unreactive amino-terminal amino acid, peptide map pattern, and immunochemical cross-reactivity with some, but not all, lambda Bence Jones proteins identifies this amyloid fibril protein as being derived primarily from the aminoterminal segment of a homogeneous lambda light polypeptide chain of an immunoglobulin protein. Although the immunoglobulin origin of amyloid fibrils has been demonstrated in several pathologic settings, this is the first example of their immunoglobulin origin in a case of amyloidosis with restricted tissue involvement.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01856034
Permalink
