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  • 1970-1974  (10)
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  • 1
    Electronic Resource
    Electronic Resource
    Effect of the branched-chain α-keto acids on pyruvate metabolism by homogenates of human brain (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb00298.x
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  • 2
    Electronic Resource
    Electronic Resource
    DEVELOPMENT OF MITOCHONDRIAL PYRUVATE METABOLISM IN RAT BRAIN (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 22 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The activities of a number of mitochondrial enzymes involved in the metabolism of pyruvate during development of the rat brain were investigated. The rates of decarboxylation of [1-14C]pyruvate to 14CO2 via pyruvate dehydrogenase and the fixation of H14CO3− in the presence of pyruvate via pyruvate carboxylase by brain homogenates were very low in newborn rats. These rates increased markedly by about four-fold and 15-fold respectively during 10–35 postnatal days. The rates of the fixation of H14CO3− by cerebral homogenates were supported by the development of the activity of pyruvate carboxylase in rat brain. The activities of citrate synthase, aconitase, NAD-malate dehydrogenase, aspartate aminotransferase, alanine aminotransferase and phosphoenol-pyruvate carboxykinase were very low in the particulate fraction of the newborn rat brain. The activities of all these enzymes increased makedly by about three- to 10-fold during 10–35 days after birth. The activity of mitochondrial phosphoenolpyruvate carboxykinase from rat brain was not precipitated by an antibody prepared against rat liver cytosolic phosphoenolpyruvate carboxykinase suggesting that cerebral mitochondrial enzyme is immunologically different from that of the cytosolic form in hepatocytes. The significance of the development of the cerebral mitochondrial metabolism is discussed in relation to biochemical maturation of the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04284.x
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  • 3
    Electronic Resource
    Electronic Resource
    THE RELATIVE SIGNIFICANCE OF CO2-FIXING ENZYMES IN THE METABOLISM OF RAT BRAIN (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 22 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To evaluate the relative significance of CO2-fixing enzymes in the metabolism of rat brain, the subcellular distribution of pyruvate carboxylase, phosphoenolpyruvate carboxykinase, NADP-isocitrate dehydrogenase and NADP-malate dehydrogenase, as well as the fixation of H14CO3− by the cytosol and the mitochondria was investigated. Pyruvate carboxylase and phosphoenol-pyruvate carboxykinase are mainly localized in the mitochondria whereas NADP-isocitrate dehydrogenase and NADP-malate dehydrogenase are present in both the cytosol and the mitochondria. In the presence of pyruvate rat brain mitochondria fixed H14CO3− at a rate of about 170 nmol/g of tissue/min whereas these organelles fixed negligible amounts of H14CO3− in the presence of α-ketoglutarate or phosphoenolpyruvate. Rat brain cortex slices fixed H14CO3− at a rate of about 7 nmol/g of tissue/min and it was increased by two-fold when pyruvate was added to the incubation medium. The carboxylation of α-ketoglutarate and pyruvate by the reversal of the cytosolic NADP-isocitrate dehydrogenase and NADP-malate dehydrogenase respectively was very low as compared to that by pyruvate carboxylase. The rate of carboxylation reaction of both NADP-isocitrate dehydrogenase and NADP-malate dehydrogenase was only about 1/10th of that of decarboxylation reaction of the same enzyme. It is suggested that under physiological conditions these two enzymes do not play a significant role in CO2-fixation in the brain. In rat brain cytosol, citrate is largely metabolized to α-ketoglutarate by a sequential action of aconitate hydratase and NADP-isocitrate dehydrogenase. The operation of the citrate-cleavage pathway in rat brain cytosol is demonstrated. The data show that among four CO2-fixing enzymes, pyruvate carboxylase, an anaplerotic enzyme, plays the major role in CO2-fixation in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04285.x
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  • 4
    Electronic Resource
    Electronic Resource
    PYRUVATE METABOLISM BY HOMOGENATES OF HUMAN BRAIN: EFFECTS OF PHENYLPYRUVATE AND IMPLICATIONS FOR THE ETIOLOGY OF THE MENTAL RETARDATION IN PHENYLKETONURIA (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The effect of phenylalanine and phenylpyruvate on the metabolism of pyruvate by homogenates of human brain was investigated. In the presence of 5 mM pyruvate as substrate homogenates of human cerebral cortex fixed about 1 μmol of H14CO3-- per g of tissue in 30 min. Phenylpyruvate at a concentration of 5 raw inhibited the fixation of H14 CO3-- by homogenates of human brain by approximately 50 per cent, whereas 5 mM phenylalanine had no effect. The inhibition of pyruvate carboxylation by phenylpyruvate was dependent upon the concentration of the inhibitor. The activity of pyruvate carboxylase (EC 6.4.1.1) in human cerebral cortex was 02–0.4 units, with a Km for pyruvate of about 0.2 mM. Homogenates of human cerebral cortex decarboxylated [1-14C]pyruvate to 14CO2 at a rate of about 5 μmol per g of tissue per 15 min, with a 20–50 per cent reduction in the presence of 5 mM phenylpyruvate; phenylalanine at the same concentration had no effect. The possible toxic effect of phenylpyruvate on the metabolism of pyruvate in the brains of untreated phenylketonuric patients is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb12128.x
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of ketone bodies on pyruvate carboxylation by rat brain mitochondria (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04415.x
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  • 6
    Electronic Resource
    Electronic Resource
    DEVELOPMENT OF LIPOGENESIS IN RAT BRAIN CORTEX: THE DIFFERENTIAL INCORPORATION OF GLUCOSE AND ACETATE INTO BRAIN LIPIDS IN VITRO (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 23 (1974), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —The oxidation to CO2 and the incorporation of [U-14C]glucose and [U-14C]acetate into lipids by cortex slices from rat brain during the postnatal period were investigated. The oxidation of [U-14C]glucose was low in 2-day-old rat brain, and increased by about two-fold during the 2nd and 3rd postnatal weeks. The oxidation of [U-14C]acetate was increased markedly in the second postnatal week, but decreased to rates observed in 2-day-old rat brain at the time of weaning. Both labeled substrates were readily incorporated into non-saponifiable lipids and fatty acids by brain slices from 2-day-old rat. Their rates of incorporation and the days on which maximum rates occurred were different, however, maximum incorporation of [U-14C]glucose and [U-14]acetate into lipid fractions being observed on about the 7th and 12th postanatal days, respectively. The metabolic compartmentation in the utilization of these substrates for lipogenesis is suggested. The activities of glucose-6-phosphate dehydrogenase, cytosolic NADP-malate dehydrogenase, cytosolic NADP-isocitrate dehydrogenase, ATP-citrate lyase and acetyl CoA carboxylase were measured in rat brain during the postnatal period. All enzymes followed somewhat different courses of development; the activity of acetyl CoA carboxylase was, however, the lowest among other key enzymes in the biosynthetic pathway, and its developmental pattern paralleled closely the fatty acid synthesis from [U-14C]glucose. It is suggested that acetyl CoA carboxylase is a rate-limiting step in the synthesis de novo of fatty acids in developing rat brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1974.tb04359.x
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  • 7
    Electronic Resource
    Electronic Resource
    Replacement of functional parenchymal cells by fat and connective tissue in human submandibular salivary glands: An age-related change (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 2 (1973), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. The ratio of functional parenchymal (acinar and duct) cells to intracapsular fat and connective tissue in human submandibular salivary glands is seen microscopically to differ from subject to subject. In the present analysis of an apparently age-related change, a modification of the random-point counting method of Chalkley (1943) of determining the relative volumes of tissue constituents from histological sections was applied to the submandibular glands of a randomly chosen sample of 36 subjects (six from each decade of age from 25–84 years) from a series of 211 consecutive autopsies. Reproducibility tests of the method of measurement and also observations on a further group of 19 healthy control subjects who had died “sudden” deaths, were made. When the values for the volume, of functional mass of acinar and duct cells relative lo that of fat and connective tissue were analyzed in relation to age, a gradual significant reduction through adult life was found (regression coefficient b =–0.28, p 〈 0.01). Moreover, the values for a further group 5–14 years of age fell close to the extrapolated regression line of the groups aged from 25 to 84 years old. The trend for reduction may therefore begin in childhood. Analysis did not indicate that either fat or connective tissue alone predominated in the replacement of secretory cells. The values were not related to the adiposity of (he subject, and no trend for change with age was found in the fresh wet weights of 60 glands from subjects aged 25–74 years. The evidence indicates an average loss of a quarter of the relative secretory cell volume between childhood and old age, by which time the more extremely affected glands may have lost one half.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1973.tb01670.x
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  • 8
    Electronic Resource
    Electronic Resource
    Identification of norcocaine as a metabolite of [3H]-cocaine in rat brain (1974)
    Springer
    Cellular and molecular life sciences 30 (1974), S. 1312-1314 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nach. s.c. und i.v. Injektionen von Cocain in Ratten wurde Cocain im Hirn rasch metabolisiert. Ausser Benzoylecgonin, Benzoylnorecgnin und Ecgonin wurde Norcocazin als wichtiger Metabolit identifiziert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945203
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  • 9
    Electronic Resource
    Electronic Resource
    Die Alkaloide aus Hedranthera barteri (Hook. f.) Pichon.Teil der Dissertation V. Agwada, Universität Zürich. 139. Mitteilung über Alkaloide138. Mitteilung: [1]. (1970)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 53 (1970), S. 1567-1577 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: From the root bark of the apocynacea Hedranthera barteri (Hook. f.) Pichon were isolated the known indole alkaloids vobtusine (1), voacamine (2), callichiline (3), voacangine (4) and conoflorine (5), as well as the unknown plant bases amataine, goziline and owerreine, and also beninine and 1, 2-dehydrobeninine. The structures of the two last mentioned alkaloids were shown in an earlier publication to be 6 and 7, respectively. Amataine, goziline and owerreine are bis-indole alkaloids, which on the basis of their chemical and spectroscopic (especially mass spectroscopic) properties have been assigned the structures 8, 9 and 10, respectively.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19700530703
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  • 10
    Electronic Resource
    Electronic Resource
    Extraction and Spectrophotometric Study of Copper(II) with 4-Isonitroso-1-phenyl-3-methyl-pyrazolone-5 (1972)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 314 (1972), S. 181-183 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19723140122
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