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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 24 (1972), S. 1-5 
    ISSN: 1432-2072
    Keywords: Schizophrenic Deficit ; Performance Tests ; Antipsychotic Drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Performance measures (such as reaction time, perceptual constancy, or word associations) can conceivably contribute to a better understanding of drug action than can behavior ratings. The reason is that they offer a greater opportunity to define and delineate behavior than do behavior ratings. In spite of a plethora of measures which are presumed to be aspects of schizophrenic deficit, less is known about drug effects on such performance measures than on sympton and behavior ratings. Difficulties with measuring performance deficit in schizophrenia arise when one wishes to separate the effects of practice, test difficulty, motivation to perform, and ability to follow test instructions from the performance function being measured. Few tests have survived or undergone replication studies. Perhaps the single outstanding exception is reaction time. Some tests show that relatively few of the patients have pathological scores. Rarely are the standard psychometric characteristics of these tests reported. The questions before this study group were: (a) What is our ability at the present time to specify some performance deficit measures in schizophrenia; and (b) considering the small number of performance measures that can be included in any single study, what are the research strategies that should be adopted?
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 24 (1972), S. 81-98 
    ISSN: 1432-2072
    Keywords: Schizophrenia ; Phenothiazines ; Reaction ; Time ; Symptoms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A battery of performance tests was administered to acutely ill schizophrenic patients prior to treatment and repeatedly during a 26-week course of treatment with one of three phenothiazines (acetophenazine, chlorpromazine or fluphenazine). Included were measures of simple reaction-time, cognitive stimulus generalization, sway suggestibility, definition of affectively toned words and subjective uncertainty. Each of these measures were chosen to reflect a specific aspect of schizophrenic deficit or dysfunction. Changes in performance over time and correlations with symptom rating scales of psychopathology presumably tapping the same schizophrenic dysfunctions were examined. Most changes in performance occured between the initial and first repeated testing. Correlations with clinical ratings were seen primarily in symptoms of withdrawal and cognitive disturbance.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 5 (1971), S. 319-333 
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Hartree-Fock wave functions for the He and Be isoelectronic sequences of ions are calculated using orbitals which are linear combinations of simple exponential functions. By a full optimization of the exponents and coefficients close approximations to the HartreeFock energies were obtained. To the same order of accuracy the resulting Hartree-Fock orbitals require fewer basis functions than used previously. A number of difficulties which arise in the numerical procedures as the size of the basis set is increased are analysed in detail. Similar results are obtained for the Li sequence using the Unrestricted HartreeFock method with and without projection.
    Additional Material: 7 Tab.
    Type of Medium: Electronic Resource
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