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  • 1
    Electronic Resource
    Electronic Resource
    On the unified laws of excitability, activity and interactivity of physiological systems (1971)
    Springer
    Biological cybernetics 9 (1971), S. 45-55 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Summary Laws of excitability, activity and interactivity were established in their basic forms concerning not only the slope and time factors of an effective stimulus to a physiological system, but also concerning relative differences in the stimulus, moving stimulus, reciprocal inhibition, etc., and further the basis was established for the unification of these laws in the above various situations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270851
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  • 2
    Electronic Resource
    Electronic Resource
    Traumatische Regeneration und Resorptivkarzinogenese am Zentralnervensystem (1971)
    Springer
    Acta neurochirurgica 25 (1971), S. 197-206 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Concerning the question of the influence of cellular proliferation in the development of tumours, both a standard brain injury and also resorptive carcinogens with a neurotropic effect have been used in rats. The “model” of the transplacental carcinogenesis was employed. The resultant tumours corresponded, both in respect of their localization and in their morphology, almost exactly to the usual picture seen in this method of investigation but without employing trauma. The only unusual feature was the development of almost pure astrocytomata, with are otherwise very rare. Trauma evidently did not influence the location of the tumours.
    Notes: Zusammenfassung Zur Frage des Einflusses der Proliferationskinetik der Zellen auf das Tumorwachstum wurde an Ratten sowohl ein Hirntrauma gesetzt als auch resorptiv wirkende Carcinogene mit neurotropem Effekt appliziert. Es wurde das ‚Modell“ der diaplazentaren Karzinogenese angewandt. Die entstandenen Tumoren entsprachen sowohl ihrer Lokalisation als auch ihrer Morphologie nach genau dem gewohnten Bild bei dieser Versuchsanordnung ohne Trauma. Außergewöhnlich war lediglich das Auftreten fast reiner Astrozytome, die sonst sehr selten sind. Das Trauma beeinflußt die Lokalisation der Geschwülste nicht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809101
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  • 3
    Electronic Resource
    Electronic Resource
    Preparation of a number of 5-butylpyrimidine nucleosides (1972)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 15 (1972), S. 1061-1065 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00280a016
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  • 4
    Electronic Resource
    Electronic Resource
    Plasma levels of antidiuretic hormone in man during methoxyflurane anaesthesia and surgery (1970)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 25 (1970), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1970.tb00256.x
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  • 5
    Electronic Resource
    Electronic Resource
    Vaccination of cattle against bovine ephemeral fever with live attenuated virus followed by killed virus (1974)
    Springer
    Archives of virology 44 (1974), S. 121-132 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serial passage of bovine ephemeral fever virus in hamster lung cells, HmLu-1, deprived rapidly the virus of virulence for cattle with simultaneous loss of the ability to produce neutralizing antibody. The attenuated virus thus obtained, however, could prime cattle to produce neutralizing antibody rapidly to high titers following a subsequent inoculation of formalin-inactivated, AIPO4 gel-adsorbed vaccine (K). Although one subcutaneous dose of live vaccine (L) prepared from the attenuated virus produces no detectable amounts of neutralizing antibody unless as heavy a dose as 107 TCID50 was used, the priming effect of L vaccine was shown even with 10 TCLD50. Similar priming effect was also shown in mice by intracerebral inoculation of L vaccine. Maximal antibody response of cattle was obtained by one subcutaneous L vaccine dose of ≥ lO5]TCID50 followed by 3 ml of K vaccine administered intramuscularly at intervals of 2 to 4 weeks. This LK method induced seroconversion in nearly all of initially seronegative cattle, and the neutralizing antibody thus produced persisted much longer than that following two doses of K vaccine given at one-month intervals. The LK method exerted little side effects in cattle. Cows vaccinated during pregnancy delivered healthy calves in term. No adverse effect on milk production was shown. The vaccine virus could not be passaged serially in calves by intravenous inoculation of the blood. Lyophilized L vaccine was stored at 4
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01250220
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  • 6
    Electronic Resource
    Electronic Resource
    Formalin-inactivated, aluminum phosphate gel-adsorbed vaccine of bovine ephemeral fever virus (1973)
    Springer
    Archives of virology 42 (1973), S. 42-53 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An inactivated vaccine prepared from virus grown in hamster lung cells produced specific neutralizing antibody by intramuscular inoculation in cattle as well as in mice. Antibody response of cattle after one dose of vaccine was poor both in antibody level and seroconversion rate. However, a second dose given at intervals of 3 or more weeks induced a rapid and high-titered antibody formation in almost all animals. The antibody levels thus attained declined rather rapidly in several months, yet a booster dose given one year later provoked a rapid antibody response. Considering this pattern of antibody response together with the seasonal incidence of the disease it seems adequate that the initial immunization with two doses and the booster inoculation be made in late spring or early summer, immediately before the epizootic season. The vaccination prevented the disease in calves challenged with virulent virus. The vaccine exerted little side effects in cattle. Cows vaccinated during pregnancy gave birth to healthy calves in term. No adverse effects of vaccination on milk production was shown. All these findings indicate efficacy and safety of the vaccine, although the final evaluation rests on largescale field trials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01250506
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  • 7
    Electronic Resource
    Electronic Resource
    Bovine respiratory syncytial virus: Host range in laboratory animals and cell cultures (1974)
    Springer
    Archives of virology 44 (1974), S. 280-290 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The host range of the bovine RS virus, strain NMK7, recovered from a diseased cow during the 1968/69 outbreak in Japan was examined both in experimental animals and cell cultures. The virus strain could be propagated serially in the brain of one-day-old DDY mice, although the virus yield was low and no illness was produced. On the other hand, the virus failed to infect adult DDY mice by various routes of inoculation. Young guinea pigs inoculated with virus intracerebrally, intranasally, intratracheally or intraperitoneally developed no illness but produced low titers of specific neutralizing antibody, indicating the occurrence of an inapparent infection. In tissue cultures, the bovine RS virus showed a wide range of susceptible host cells. It replicated in all cell species (kidney, testicle, thyroid, thymus, duodenum, rectum) of bovine origin as well as in cell cultures from swine (embryonic kidney), hamster (lung, kidney), monkey kidney (Vero), and human (embryonic lung and kidney, HeLa, HEp-2). Better growth was observed in bovine than in human cell cultures. The simultaneously tested human RS virus (strain Long) exhibited a smaller host cell range in cultures of animal provenance and showed optimal growth in human cells. Both virus strains failed to propagate in chicken cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01240616
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  • 8
    Electronic Resource
    Electronic Resource
    New serotypes of reoviruses isolated from cattle (1974)
    Springer
    Archives of virology 45 (1974), S. 157-160 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01240556
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  • 9
    Electronic Resource
    Electronic Resource
    The incorporation of45Ca into the egg of the Medaka,Oryzias latipes (1973)
    Springer
    Cellular and molecular life sciences 29 (1973), S. 144-145 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Zur Markierung des intrazellulären Ca im Fisch-Ei wurde45CaCl2-enthaltende Ringer-Lösung in die Abdominalhöhle vonOryzias latipes injiziert. 2–3 Tage nach der Injektion zeigt die Radioaktivität der abgelegten Eier ihr Maximum und nimmt dann allmählich ab. Aus Mikroautoradiogrammen der abgelegten Eier geht hervor, dass45Ca im Chorion und innerhalb des Eies eingebaut wird.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945437
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  • 10
    Electronic Resource
    Electronic Resource
    Some characteristics of adrenergic human eccrine sweating (1974)
    Springer
    Cellular and molecular life sciences 30 (1974), S. 40-41 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Durch Epinephrine stimulierte menschliche Schweissdrüsen produzierten ein Sekret, welches 35–45 mÄq/l Natriumionen, 10–18 mÄq/l Kaliumionen und 15–19 mÄq/l Lactat enthielt. Adrenergisch stimulierter Schweiss hat demnach eine ähnliche Zusammensetzung wie cholinergisch stimulierter Schweiss. Mit dem Elektronenmikroskop liess sich nach der Stimulation durch Epinephrin eine deutliche Erweiterung der interzellulären Kanälchen zeigen. Diese und andere schon berichteten Beobachtungen sprechen dafür, dass Epinephrin die sezernierenden Zellen in einer ähnlichen Weise wie die cholinergischen Pharmaka direkt stimuliert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01921584
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