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  • 1970-1974  (4)
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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 79 (1972), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: During a period of 76 months 252 intrauterine blood transfusions were performed on 166 out of 1600 fetuses in rhesus-immunized pregnancies. A standard transfusion technique was developed by a small obstetrical and radiological team, and the improved results associated with increasing experience are described. During the last two years the fetal transfusion rate in rhesus-immunized pregnancies reached 18 per cent, but it was only 13 per cent if patients transferred from other centres dealing with rhesus immunization are excluded. The immediate fetal mortality rate for the procedure was reduced to 12 per cent and the eventual perinatal survival rate was increased to 47 per cent during this final two-year period. Factors influencing the fetal and neonatal mortality are considered, and the maternal complications are described. The practical implications of the cord blood findings in babies born alive after single intrauterine transfusions are discussed, and the so-far satisfactory mental and physical development of surviving infants is noted.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 77 (1970), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The further development of the previously described action line method of determining the time for intrauterine transfusion or delivery in rhesus iso-immunization has been described. The method is easily interpreted and only occasionally requires more than two amniocenteses. It was used in 407 pregnancies with rhesus isoimmunization completed during a 30-month period, a further 127 being managed correctly by other criteria.Correct management along these lines reduced the rhesus mortality rate (including abortions) to 11·6 per cent, and to 9·5 per cent if high risk cases transferred from other rhesus centres are excluded. Reduction in rhesus mortality was particularly striking in first affected pregnancies (3·4 per cent) and when previous babies had required exchange transfusion but had survived (9·6 per cent).Unnecessary prematurity was almost entirely eliminated in mildly affected and unaffected babies.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 80 (1973), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The lecithin : sphingomyelin area ratio (LSAR) was measured in 108 samples of amniotic fluid obtained after 32 weeks' gestation from 66 pregnant diabetics and in 34 samples from 27 women with latent diabetes during pregnancy. A previously reported finding that the normal terminal rise in the ratio did not occur in approximately one-third of such patients was confirmed. The clinical value of this test, in timing delivery to minimize the risk of neonatal respiratory distress, is discussed; its routine use in pregnancies complicated by established or latent diabetes is advocated.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 78 (1971), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Total dose iron-dextran infusion is a practical and effective procedure for the treatment of most cases of severe or moderately severe pregnancy anaemia. A post-infusion reticulocyte count is advocated to forecast the likely haemoglobin response. With this procedure, and provided that further regular haemoglobin estimations are made, it is suggested that routine simultaneous administration of folic acid is not necessary. An unsatisfactory reticulocyte response should draw attention to the likelihood of either urinary tract infection or megaloblastic anaemia. Early recognition of the latter important complication is therefore facilitated by the recommended regime.
    Type of Medium: Electronic Resource
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