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Genetic Differences in Conformational Changes of Albumin in the House Mouse (1973)

WILCOX, F. H.

[s.l.] : Nature Publishing Group

Nature 246 (1973), S. 35-35

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Livers from male C3H/HeJ and SWR/J mice were homogenized and centrifuged, and the supernatant was extracted using procedures described before1. One volume of horse serum albumin (HSA, Fraction V, Sigma, 5 mg ml"1 in 0.25 M sucrose) was added to 9 volumes of extract. An equal volume of solvent ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/246035a0

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Genetic differences in alteration of albumin in the house mouse, Mus musculus (1973)

Wilcox, F. H.

Springer

Biochemical genetics 10 (1973), S. 69-78

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ISSN: 1573-4927

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract Two strains of mice were shown to differ in relative proportion of two major protein bands of liver under acid conditions of electrophoresis. Genetic control was autosomal and by a pair of dominant and recessive genes. The difference was observed only if liver homogenates were extracted by treating with dilute acid and alkali. The two protein bands were identified as albumin on the basis of electrophoretic migration, molecular weight, and immunological response. No differences were found between strains in relative amounts of comparable bands of plasma. However, in studies with extraction of mixtures, liver homogenates of one strain but not another were capable of converting a large proportion of albumin from several sources to a faster-migrating form. It was concluded that the strains differ in a factor in liver capable of causing a secondary modification of the albumin molecule.