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Digitale Medien

The ECG pad lottery – it could be you! (2000)

Brown, J. R.

Oxford, UK : Blackwell Science Ltd

Anaesthesia 55 (2000), S. 0

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ISSN: 1365-2044

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1365-2044.2000.01425-36.x

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Digitale Medien

Substance P induction of murine keratinocyte PAM 212 interleukin 1 production is mediated by the neurokinin 2 receptor (NK-2R) (2000)

Song, I.-S. ; Bunnett, N. W. ; Olerud, J. E. ; [weitere]

Copenhagen : Munksgaard International Publishers

Experimental dermatology 9 (2000), S. 0

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ISSN: 1600-0625

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract: The neurological system plays an important role in modulating some inflammatory skin diseases. Neuro-cutaneous interactions may be mediated by the release of neuropeptides such as substance P (SP) which activate immunocompetent cells in the skin by binding to high affinity neurokinin receptors (NKR). Since epidermal keratinocytes produce a variety of cytokines and are intimately associated with cutaneous sensory fibers, we tested the ability of these cells to participate in the cutaneous neuroimmune system by the secretion of potent cytokines such as interleukin 1 (IL-1) in response to released SP. RT-PCR studies demonstrated that cultured PAM 212 murine keratinocytes expressed mRNA for NK-2R but not NK-1R. Correspondingly, the addition of SP to these cells resulted in a rapid increase in intracellular Ca2+ levels that could be specifically blocked by an NK-2R antagonist. NK-2R was also shown in normal mouse epidermis by immunohistochemistry. SP augmented the expression of PAM 212 keratinocyte IL-1α mRNA in a dose and time dependent manner and this induction was inhibited by an NK-2R antagonist. Secretion of bioactive IL-1α by the PAM 212 keratinocytes was likewise stimulated by SP in a dose dependent manner. These data support the hypothesis that SP released from cutaneous sensory nerves contributes to neuroimmune inflammatory responses in the skin by modulating the expression and release of cytokines from epidermal keratinocytes.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1034/j.1600-0625.2000.009001042.x

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Digitale Medien

HARTLEY, B. S. ; BROWN, J. R. ; KAUFFMAN, DOROTHY L. ; [weitere]

[s.l.] : Nature Publishing Group

Nature 207 (1965), S. 1157-1159

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] IT is now generally agreed that the amino-acid sequence of a protein is determined by the nucleotide sequence of its parent gene, so that comparison of the sequences of related proteins can provide clues about their genetic origins. If we compare similar proteins from different species we may hope ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/2071157a0

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Decomposition of the water-soluble fraction of sudangrass residue in soil (1968)

Brown, J. R. ; Frederick, L. R.

Springer

Plant and soil 28 (1968), S. 467-470

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ISSN: 1573-5036

Quelle: Springer Online Journal Archives 1860-2000

Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft

Notizen: Summary Ground sudangrass forage was extracted at room temperature with demineralized water. The insoluble residue, the water-soluble residue, unextracted sudangrass and the recombined soluble and insoluble fractions were incubated in remoistened, air-dried soil to measure the influence of the water-soluble fraction on net carbon dioxide evolution. The maximum rate of carbon dioxide evolution from the check soil and from any treatment containing the water-soluble fraction of sudangrass occurred about 14 hours after initiation of incubation. Maximum rate of carbon dioxide evolution from the soil treated with the insoluble residue occurred about 39 hours after initiation of the incubation. The rate of carbon dioxide evolution from the soil which received the water-soluble residue was not significantly different from the rate from the check soil after 44 hours of incubation.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01373596

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Digitale Medien

Poly-1,6-Diselenahexamethylene, 1,2-diselenane, and their effects on vinyl polymerizations (1967)

Brown, J. R. ; Gillman, G. P. ; George, M. H.

New York : Wiley-Blackwell

Journal of Polymer Science Part A-1: Polymer Chemistry 5 (1967), S. 903-916

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ISSN: 0449-296X

Schlagwort(e): Physics ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Poly-1,6-diselenahexamethylene has been prepared, and some of its properties and those of its depolymerization product, 1,2-diselenane, have been studied. Depolymerization probably occurs by a free-radical mechanism. The effects of these organoselenium compounds on the thermal polymerization of styrene, methyl methacrylate, vinyl acetate, and acrylonitrile at 60°C. in the presence and absence of 2,2′-azobisisobutyronitrile and on the direct photopolymerization of these vinyl monomers at 25°C. has been examined. Various reaction mechanisms are suggested to explain the experimental results.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/pol.1967.150050416

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